1 to 10 of 76 literature results

• Structure of the DNA repair helicase XPD.

  The XPD helicase (Rad3 in Saccharomyces cerevisiae) is a component of transcription factor IIH (TFIIH), which functions in transcription initiation an…

  Authors: Huanting Liu, Jana Rudolf, Kenneth A Johnson, Stephen A McMahon, Muse Oke, Lester Carter, Anne-Marie McRobbie, Sara E Brown, James H Naismith, Malcolm F White

  Source: Cell. 2008 May 30

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• Wza the translocon for E. coli capsular polysaccharides defines a new class of membrane protein.

  Many types of bacteria produce extracellular polysaccharides (EPSs). Some are secreted polymers and show only limited association with the cell surfac…

  Authors: Changjiang Dong, Konstantinos Beis, Jutta Nesper, Anne L Brunkan-Lamontagne, Bradley R Clarke, Chris Whitfield, James H Naismith

  Source: Nature. 2006 Nov 9

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• Periplasmic export machines for outer membrane assembly.

  The cell envelope of Gram-negative bacteria protects the organism from environmental stresses, components of the innate immune response, and the actio…

  Authors: Chris Whitfield, James H Naismith

  Source: Current opinion in structural biology. 2008 Aug

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• Inferring the chemical mechanism from structures of enzymes.

  Chemistry has once again embraced the study of enzyme mechanism as a core discipline. Chemists are uniquely able to contribute to the analysis of enzy…

  Authors: James H Naismith

  Source: Chemical Society reviews. 2006 Sep

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• Adenylate-forming enzymes.

  Thioesters, amides, and esters are common chemical building blocks in a wide array of natural products. The formation of these bonds can be catalyzed …

  Authors: Stefan Schmelz, James H Naismith

  Source: Current opinion in structural biology. 2009 Dec

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• Crystal structure and mechanism of a bacterial fluorinating enzyme.

  Fluorine is the thirteenth most abundant element in the earth's crust, but fluoride concentrations in surface water are low and fluorinated metabolite…

  Authors: Changjiang Dong, Fanglu Huang, Hai Deng, Christoph Schaffrath, Jonathan B Spencer, David O'Hagan, James H Naismith

  Source: Nature. 2004 Feb 5

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• Structural basis of substrate binding in WsaF, a rhamnosyltransferase from Geobacillus stearothermophilus.

  Carbohydrate polymers are medically and industrially important. The S-layer of many Gram-positive organisms comprises protein and carbohydrate polymer…

  Authors: Kerstin Steiner, Gregor Hagelueken, Paul Messner, Christina Schäffer, James H Naismith

  Source: Journal of molecular biology. 2010 Mar 26

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• Structural insights into regioselectivity in the enzymatic chlorination of tryptophan.

  The regioselectively controlled introduction of chlorine into organic molecules is an important biological and chemical process. This importance deriv…

  Authors: Xiaofeng Zhu, Walter De Laurentis, Khim Leang, Julia Herrmann, Katja Ihlefeld, Karl-Heinz van Pée, James H Naismith

  Source: Journal of molecular biology. 2009 Aug 7

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• Crystal structures of Wzb of Escherichia coli and CpsB of Streptococcus pneumoniae, representatives of two families of tyrosine phosphatases that regulate capsule assembly.

  Many Gram-positive and Gram-negative bacteria utilize polysaccharide surface layers called capsules to evade the immune system; consequently, the synt…

  Authors: Gregor Hagelueken, Hexian Huang, Iain L Mainprize, Chris Whitfield, James H Naismith

  Source: Journal of molecular biology. 2009 Sep 25

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• Mechanism of enzymatic fluorination in Streptomyces cattleya.

  Recently a fluorination enzyme was identified and isolated from Streptomyces cattleya, as the first committed step on the metabolic pathway to the flu…

  Authors: Xiaofeng Zhu, David A Robinson, Andrew R McEwan, David O'Hagan, James H Naismith

  Source: Journal of the American Chemical Society. 2007 Nov 28

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