1 to 10 of 11 literature results

• Local increase in thymic stromal lymphopoietin induces systemic alterations in B cell development.

  The cytokine thymic stromal lymphopoietin (TSLP) drives immature B cell development in vitro and may regulate T helper type 2 responses. Here we analy…

  Authors: Alexander Astrakhan, Miyuki Omori, Thuc Nguyen, Shirly Becker-Herman, Masanori Iseki, Theingi Aye, Kelly Hudkins, James Dooley, Andrew Farr, Charles E Alpers,…

  Source: Nature immunology. 2007 May

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• Notch ligands Delta 1 and Jagged1 transmit distinct signals to T-cell precursors.

  Signaling through the Notch pathway plays an essential role in inducing T-lineage commitment and promoting the maturation of immature thymocytes. Usin…

  Authors: Sophie M Lehar, James Dooley, Andrew G Farr, Michael J Bevan

  Source: Blood. 2005 Feb 15

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• Regulation of thymic epithelium by keratinocyte growth factor.

  Here we demonstrate that keratinocyte growth factor (KGF) and FGFR2IIIb signaling can affect development and function of thymic epithelium (TE) and th…

  Authors: Matthew Erickson, Stanislaw Morkowski, Sophie Lehar, Geoffrey Gillard, Courtney Beers, James Dooley, Jeffrey S Rubin, Alexander Rudensky, Andrew G Farr

  Source: Blood. 2002 Nov 1

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• Lessons from thymic epithelial heterogeneity: FoxN1 and tissue-restricted gene expression by extrathymic, endodermally derived epithelium.

  Modeling of thymic epithelial differentiation has been guided by several important underlying assumptions. One is that within epithelial tissues deriv…

  Authors: James Dooley, Matthew Erickson, Andrew G Farr

  Source: Journal of immunology (Baltimore, Md. : 1950). 2009 Oct 15

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• Alterations of the medullary epithelial compartment in the Aire-deficient thymus: implications for programs of thymic epithelial differentiation.

  A widely held model of thymic epithelial differentiation is based on patterns of keratin expression, where a K8(+)K5(+) progenitor gives rise to K8(+)…

  Authors: James Dooley, Matthew Erickson, Andrew G Farr

  Source: Journal of immunology (Baltimore, Md. : 1950). 2008 Oct 15

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• An organized medullary epithelial structure in the normal thymus expresses molecules of respiratory epithelium and resembles the epithelial thymic rudiment of nude mice.

  The expression of tissue-specific Ags (TSA) within the thymic environment has emerged as an important contribution to the establishment of self-tolera…

  Authors: James Dooley, Matt Erickson, Andrew G Farr

  Source: Journal of immunology (Baltimore, Md. : 1950). 2005 Oct 1

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• FGFR2IIIb signaling regulates thymic epithelial differentiation.

  Heterogeneous epithelial populations comprising the thymic environment influence early and late stages of T-cell development. The processes that regul…

  Authors: James Dooley, Matthew Erickson, William J Larochelle, Geoffrey O Gillard, Andrew G Farr

  Source: Developmental dynamics : an official publication of the American Association of Anatomists. 2007 Dec

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• Aire-dependent alterations in medullary thymic epithelium indicate a role for Aire in thymic epithelial differentiation.

  The prevalent view of thymic epithelial differentiation and Aire activity holds that Aire functions in terminally differentiated medullary thymic epit…

  Authors: Geoffrey O Gillard, James Dooley, Matthew Erickson, Leena Peltonen, Andrew G Farr

  Source: Journal of immunology (Baltimore, Md. : 1950). 2007 Mar 1

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• Cervical thymus in the mouse.

  Although thymic ectopy has long been recognized in humans, the functional activity or potential immunological significance of this thymic tissue is un…

  Authors: James Dooley, Matthew Erickson, Geoffrey O Gillard, Andrew G Farr

  Source: Journal of immunology (Baltimore, Md. : 1950). 2006 Jun 1

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• Nude thymic rudiment lacking functional foxn1 resembles respiratory epithelium.

  The epithelial compartment of the thymus arises from endoderm of the 3rd pharyngeal pouch. As it moves from a cervical to a mediastinal position durin…

  Authors: James Dooley, Matthew Erickson, Henk Roelink, Andrew G Farr

  Source: Developmental dynamics : an official publication of the American Association of Anatomists. 2005 Aug

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