1 to 10 of 141 literature results

• Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10.

  Development and homeostasis of the cardiovascular system require intimate interactions between endothelial and smooth muscle cells, which form a seaml…

  Authors: Shurong Chang, Bryan D Young, Shijie Li, Xiaoxia Qi, James A Richardson, Eric N Olson

  Source: Cell. 2006 Jul 28

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• MicroRNAs miR-143 and miR-145 modulate cytoskeletal dynamics and responsiveness of smooth muscle cells to injury.

  Vascular injury triggers dedifferentiation and cytoskeletal remodeling of smooth muscle cells (SMCs), culminating in vessel occlusion. Serum response …

  Authors: Mei Xin, Eric M Small, Lillian B Sutherland, Xiaoxia Qi, John McAnally, Craig F Plato, James A Richardson, Rhonda Bassel-Duby, Eric N Olson

  Source: Genes & development. 2009 Sep 15

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• A family of microRNAs encoded by myosin genes governs myosin expression and muscle performance.

  Myosin is the primary regulator of muscle strength and contractility. Here we show that three myosin genes, Myh6, Myh7, and Myh7b, encode related intr…

  Authors: Eva van Rooij, Daniel Quiat, Brett A Johnson, Lillian B Sutherland, Xiaoxia Qi, James A Richardson, Robert J Kelm, Eric N Olson

  Source: Developmental cell. 2009 Nov

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• Identification of a hormonal basis for gallbladder filling.

  The cycle of gallbladder filling and emptying controls the flow of bile into the intestine for digestion. Here we show that fibroblast growth factor-1…

  Authors: Mihwa Choi, Antonio Moschetta, Angie L Bookout, Li Peng, Michihisa Umetani, Sam R Holmstrom, Kelly Suino-Powell, H Eric Xu, James A Richardson, Robert D Gerard,…

  Source: Nature medicine. 2006 Nov

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• microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart.

  MicroRNAs (miRNAs) modulate gene expression by inhibiting mRNA translation and promoting mRNA degradation, but little is known of their potential role…

  Authors: Ning Liu, Svetlana Bezprozvannaya, Andrew H Williams, Xiaoxia Qi, James A Richardson, Rhonda Bassel-Duby, Eric N Olson

  Source: Genes & development. 2008 Dec 1

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• The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases.

  Postnatal cardiac myocytes respond to diverse signals by hypertrophic growth and activation of a fetal gene program. In an effort to discover regulato…

  Authors: Kunhua Song, Johannes Backs, John McAnally, Xiaoxia Qi, Robert D Gerard, James A Richardson, Joseph A Hill, Rhonda Bassel-Duby, Eric N Olson

  Source: Cell. 2006 May 5

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• The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesis.

  Endothelial cells play essential roles in maintenance of vascular integrity, angiogenesis, and wound repair. We show that an endothelial cell-restrict…

  Authors: Shusheng Wang, Arin B Aurora, Brett A Johnson, Xiaoxia Qi, John McAnally, Joseph A Hill, James A Richardson, Rhonda Bassel-Duby, Eric N Olson

  Source: Developmental cell. 2008 Aug

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• Histone deacetylases 1 and 2 redundantly regulate cardiac morphogenesis, growth, and contractility.

  Histone deacetylases (HDACs) tighten chromatin structure and repress gene expression through the removal of acetyl groups from histone tails. The clas…

  Authors: Rusty L Montgomery, Christopher A Davis, Matthew J Potthoff, Michael Haberland, Jens Fielitz, Xiaoxia Qi, Joseph A Hill, James A Richardson, Eric N Olson

  Source: Genes & development. 2007 Jul 15

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• Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity.

  During Drosophila embryogenesis, the dorsal transcription factor activates the expression of twist, a transcription factor required for mesoderm forma…

  Authors: Drazen Sosić, James A Richardson, Kai Yu, David M Ornitz, Eric N Olson

  Source: Cell. 2003 Jan 24

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• MEF2C transcription factor controls chondrocyte hypertrophy and bone development.

  Chondrocyte hypertrophy is essential for endochondral bone development. Unexpectedly, we discovered that MEF2C, a transcription factor that regulates …

  Authors: Michael A Arnold, Yuri Kim, Michael P Czubryt, Dillon Phan, John McAnally, Xiaoxia Qi, John M Shelton, James A Richardson, Rhonda Bassel-Duby, Eric N Olson

  Source: Developmental cell. 2007 Mar

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