1 to 9 of 9 literature results

• The nucleoporin RanBP2 has SUMO1 E3 ligase activity.

  Posttranslational modification with SUMO1 regulates protein/protein interactions, localization, and stability. SUMOylation requires the E1 enzyme Aos1…

  Authors: Andrea Pichler, Andreas Gast, Jacob S Seeler, Anne Dejean, Frauke Melchior

  Source: Cell. 2002 Jan 11

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• Functional interaction of AIRE with PIAS1 in transcriptional regulation.

  AIRE (autoimmune regulator) promotes the establishment of self-tolerance by regulating gene expression in the thymus. Mutations in AIRE lead to an aut…

  Authors: Tanja Ilmarinen, Hannele Kangas, Taina Kytömaa, Petra Eskelin, Juha Saharinen, Jacob-S Seeler, Kimmo Tanhuanpää, Fiona Yih-Ling Chan, Robyn Maree Slattery, Kirsi Alakurtti,…

  Source: Molecular immunology. 2008 Apr

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• Coordinated methyl and RNA binding is required for heterochromatin localization of mammalian HP1alpha.

  In mammalian cells, as in Schizosaccharomyces pombe and Drosophila, HP1 proteins bind histone H3 tails methylated on lysine 9 (K9). However, whereas K…

  Authors: Christian Muchardt, Marie Guilleme, Jacob-S Seeler, Didier Trouche, Anne Dejean, Moshe Yaniv

  Source: EMBO reports. 2002 Oct

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• Human BAHD1 promotes heterochromatic gene silencing.

  Gene silencing via heterochromatin formation plays a major role in cell differentiation and maintenance of homeostasis. Here we report the identificat…

  Authors: Hélène Bierne, To Nam Tham, Eric Batsche, Anne Dumay, Morwenna Leguillou, Sophie Kernéis-Golsteyn, Béatrice Regnault, Jacob S Seeler, Christian Muchardt, Jean Feunteun,…

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2009 Aug 18

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• PARP-1 transcriptional activity is regulated by sumoylation upon heat shock.

  Heat shock and other environmental stresses rapidly induce transcriptional responses subject to regulation by a variety of post-translational modifica…

  Authors: Nadine Martin, Klaus Schwamborn, Valérie Schreiber, Andreas Werner, Christelle Guillier, Xiang-Dong Zhang, Oliver Bischof, Jacob-S Seeler, Anne Dejean

  Source: The EMBO journal. 2009 Nov 18

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• Role of SUMO in the dynamics of telomere maintenance in fission yeast.

  The sheltering of chromosome ends from illegitimate DNA repair reactions and telomere length homeostasis are critical for preserving genomic integrity…

  Authors: Blerta Xhemalce, Eva Madi Riising, Peter Baumann, Anne Dejean, Benoît Arcangioli, Jacob-S Seeler

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2007 Jan 16

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• Nuclear and unclear functions of SUMO.

  Post-translational modification by the ubiquitin-like SUMO protein is emerging as a defining feature of eukaryotic cells. Sumoylation has crucial role…

  Authors: Jacob-S Seeler, Anne Dejean

  Source: Nature reviews. Molecular cell biology. 2003 Sep

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• Role of the fission yeast SUMO E3 ligase Pli1p in centromere and telomere maintenance.

  Sumoylation represents a conserved mechanism of post-translational protein modification. We report that Pli1p, the unique fission yeast member of the …

  Authors: Blerta Xhemalce, Jacob-S Seeler, Geneviève Thon, Anne Dejean, Benoît Arcangioli

  Source: The EMBO journal. 2004 Oct 1

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• The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase.

  Transcriptional repression mediated through histone deacetylation is a critical component of eukaryotic gene regulation. Here we demonstrate that the …

  Authors: Olivier Kirsh, Jacob-S Seeler, Andrea Pichler, Andreas Gast, Stefan Müller, Eric Miska, Marion Mathieu, Annick Harel-Bellan, Tony Kouzarides, Frauke Melchior,…

  Source: The EMBO journal. 2002 Jun 3

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