1 to 8 of 8 literature results

• STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane.

  As the sole Ca2+ entry mechanism in a variety of non-excitable cells, store-operated calcium (SOC) influx is important in Ca2+ signalling and many oth…

  Authors: Shenyuan L Zhang, Ying Yu, Jack Roos, J Ashot Kozak, Thomas J Deerinck, Mark H Ellisman, Kenneth A Stauderman, Michael D Cahalan

  Source: Nature. 2005 Oct 6

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• Dap160/intersectin scaffolds the periactive zone to achieve high-fidelity endocytosis and normal synaptic growth.

  Dap160/Intersectin is a multidomain adaptor protein that colocalizes with endocytic machinery in the periactive zone at the Drosophila NMJ. We have ge…

  Authors: Bruno Marie, Sean T Sweeney, Kira E Poskanzer, Jack Roos, Regis B Kelly, Graeme W Davis

  Source: Neuron. 2004 Jul 22

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• Synaptojanin is recruited by endophilin to promote synaptic vesicle uncoating.

  We describe the isolation and characterization of Drosophila synaptojanin (synj) mutants. synj encodes a phosphatidylinositol phosphatase involved in …

  Authors: Patrik Verstreken, Tong-Wey Koh, Karen L Schulze, R Grace Zhai, P Robin Hiesinger, Yi Zhou, Sunil Q Mehta, Yu Cao, Jack Roos, Hugo J Bellen

  Source: Neuron. 2003 Nov 13

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• Molecular basis of the CRAC channel.

  Ca(2+) release-activated Ca(2+) (CRAC) channels, located in the plasma membrane, are opened upon release of Ca(2+) from intracellular stores, permitti…

  Authors: Michael D Cahalan, Shenyuan L Zhang, Andriy V Yeromin, Kari Ohlsen, Jack Roos, Kenneth A Stauderman

  Source: Cell calcium. 2007 Aug

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• Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation.

  For efficient development of an immune response, T lymphocytes require long-lasting calcium influx through calcium release-activated calcium (CRAC) ch…

  Authors: Maria I Lioudyno, J Ashot Kozak, Aubin Penna, Olga Safrina, Shenyuan L Zhang, Debasish Sen, Jack Roos, Kenneth A Stauderman, Michael D Cahalan

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2008 Feb 12

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• A store-operated calcium channel in Drosophila S2 cells.

  Using whole-cell recording in Drosophila S2 cells, we characterized a Ca(2+)-selective current that is activated by depletion of intracellular Ca2+ st…

  Authors: Andriy V Yeromin, Jack Roos, Kenneth A Stauderman, Michael D Cahalan

  Source: The Journal of general physiology. 2004 Feb

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• Genome-wide RNAi screen of Ca(2+) influx identifies genes that regulate Ca(2+) release-activated Ca(2+) channel activity.

  Recent studies by our group and others demonstrated a required and conserved role of Stim in store-operated Ca(2+) influx and Ca(2+) release-activated…

  Authors: Shenyuan L Zhang, Andriy V Yeromin, Xiang H-F Zhang, Ying Yu, Olga Safrina, Aubin Penna, Jack Roos, Kenneth A Stauderman, Michael D Cahalan

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2006 Jun 13

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• STIM1, an essential and conserved component of store-operated Ca2+ channel function.

  Store-operated Ca2+ (SOC) channels regulate many cellular processes, but the underlying molecular components are not well defined. Using an RNA interf…

  Authors: Jack Roos, Paul J DiGregorio, Andriy V Yeromin, Kari Ohlsen, Maria Lioudyno, Shenyuan Zhang, Olga Safrina, J Ashot Kozak, Steven L Wagner, Michael D Cahalan,…

  Source: The Journal of cell biology. 2005 May 9

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