1 to 10 of 2,983 literature results

• Direct brain recordings fuel advances in cognitive electrophysiology.

  Electrocorticographic brain recordings in patients with surgically implanted electrodes have recently emerged as a powerful tool for examining the neu…

  Authors: Joshua Jacobs, Michael J Kahana

  Source: Trends in cognitive sciences. 2010 Feb 25

  View Full Text

• What everybody should know about the rat genome and its online resources.

  It has been four years since the original publication of the draft sequence of the rat genome. Five groups are now working together to assemble, annot…

  Authors: Simon N Twigger, Kim D Pruitt, Xosé M Fernández-Suárez, Donna Karolchik, Kim C Worley, Donna R Maglott, Garth Brown, George Weinstock, Richard A Gibbs, Jim Kent,…

  Source: Nature genetics. 2008 May

  View Free Full Text

• A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.

  We conducted a genome-wide association study of pancreatic cancer in 3,851 affected individuals (cases) and 3,934 unaffected controls drawn from 12 pr…

  Authors: Gloria M Petersen, Laufey Amundadottir, Charles S Fuchs, Peter Kraft, Rachael Z Stolzenberg-Solomon, Kevin B Jacobs, Alan A Arslan, H Bas Bueno-de-Mesquita, Steven Gallinger, Myron Gross,…

  Source: Nature genetics. 2010 Mar

  View Full Text

• The role of apolipoprotein E in Alzheimer's disease.

  The epsilon4 allele of apolipoprotein E (APOE) is the major genetic risk factor for Alzheimer's disease (AD). Although there have been numerous studie…

  Authors: Jungsu Kim, Jacob M Basak, David M Holtzman

  Source: Neuron. 2009 Aug 13

  View Full Text

• Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties.

  During acute infections, a small population of effector CD8(+) T cells evades terminal differentiation and survives as long-lived memory T cells. We d…

  Authors: Rachel L Rutishauser, Gislâine A Martins, Sergey Kalachikov, Anmol Chandele, Ian A Parish, Eric Meffre, Joshy Jacob, Kathryn Calame, Susan M Kaech

  Source: Immunity. 2009 Aug 21

  View Full Text

• Genetic regulation of the response to Her-2 DNA vaccination in human Her-2 transgenic mice.

  Genetic regulation of immune reactivity to Her-2 vaccination and the consequent antitumor effect was tested in human Her-2 transgenic (Tg) mice of C57…

  Authors: Olga Radkevich-Brown, Jennifer Jacob, Michael Kershaw, Wei-Zen Wei

  Source: Cancer research. 2009 Jan 1

  View Free Full Text

• A module of negative feedback regulators defines growth factor signaling.

  Signaling pathways invoke interplays between forward signaling and feedback to drive robust cellular response. In this study, we address the dynamics …

  Authors: Ido Amit, Ami Citri, Tal Shay, Yiling Lu, Menachem Katz, Fan Zhang, Gabi Tarcic, Doris Siwak, John Lahad, Jasmine Jacob-Hirsch,…

  Source: Nature genetics. 2007 Apr

  View Full Text

• Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer.

  We conducted a two-stage genome-wide association study of pancreatic cancer, a cancer with one of the lowest survival rates worldwide. We genotyped 55…

  Authors: Laufey Amundadottir, Peter Kraft, Rachael Z Stolzenberg-Solomon, Charles S Fuchs, Gloria M Petersen, Alan A Arslan, H Bas Bueno-de-Mesquita, Myron Gross, Kathy Helzlsouer, Eric J Jacobs,…

  Source: Nature genetics. 2009 Sep

  View Full Text

• Case-Control Study of Overweight, Obesity, and Colorectal Cancer Risk, Overall and by Tumor Microsatellite Instability Status.

  Background Being overweight or obese is an established risk factor for colorectal cancer, more so for men than for women. Approximately 10%-20% of col…

  Authors: Peter T Campbell, Elizabeth T Jacobs, Cornelia M Ulrich, Jane C Figueiredo, Jenny N Poynter, John R McLaughlin, Robert W Haile, Eric J Jacobs, Polly A Newcomb, John D Potter,…

  Source: Journal of the National Cancer Institute. 2010 Mar 5

  View Full Text

• Progress and prospects in rat genetics: a community view.

  The rat is an important system for modeling human disease. Four years ago, the rich 150-year history of rat research was transformed by the sequencing…

  Authors: Timothy J Aitman, John K Critser, Edwin Cuppen, Anna Dominiczak, Xose M Fernandez-Suarez, Jonathan Flint, Dominique Gauguier, Aron M Geurts, Michael Gould, Peter C Harris,…

  Source: Nature genetics. 2008 May

  View Full Text