1 to 10 of 129 literature results

• Fatty acid-induced mitochondrial uncoupling in adipocytes as a key protective factor against insulin resistance and beta cell dysfunction: a new concept in the pathogenesis of obesity-associated type 2 diabetes mellitus.

  Type 2 diabetes is associated with excessive food intake and a sedentary lifestyle. Local inflammation of white adipose tissue induces cytokine-mediat…

  Authors: J A Maassen, J A Romijn, R J Heine

  Source: Diabetologia. 2007 Oct

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• Combined effects of single-nucleotide polymorphisms in GCK, GCKR, G6PC2 and MTNR1B on fasting plasma glucose and type 2 diabetes risk.

  AIMS/HYPOTHESIS: Variation in fasting plasma glucose (FPG) within the normal range is a known risk factor for the development of type 2 diabetes. Seve…

  Authors: E Reiling, E van 't Riet, M J Groenewoud, L M C Welschen, E C van Hove, G Nijpels, J A Maassen, J M Dekker, L M 't Hart

  Source: Diabetologia. 2009 Sep

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• Genetic influences on the insulin response of the beta cell to different secretagogues.

  AIMS/HYPOTHESIS: The aim of the present study was to estimate the heritability of the beta cell insulin response to glucose and to glucose combined wi…

  Authors: A M C Simonis-Bik, E M W Eekhoff, M H M de Moor, M H H Kramer, D I Boomsma, R J Heine, J M Dekker, J A Maassen, L M 't Hart, M Diamant,…

  Source: Diabetologia. 2009 Dec

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• Loss of 50% of excess weight using a very low energy diet improves insulin-stimulated glucose disposal and skeletal muscle insulin signalling in obese insulin-treated type 2 diabetic patients.

  AIMS/HYPOTHESIS: Both energy restriction (ER) per se and weight loss improve glucose metabolism in obese insulin-treated type 2 diabetic patients. Sho…

  Authors: I M Jazet, G Schaart, A Gastaldelli, E Ferrannini, M K Hesselink, P Schrauwen, J A Romijn, J A Maassen, H Pijl, D M Ouwens,…

  Source: Diabetologia. 2008 Feb

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• Diabetes-associated mitochondrial DNA mutation A3243G impairs cellular metabolic pathways necessary for beta cell function.

  AIMS/HYPOTHESIS: Mitochondrial DNA (mtDNA) mutations cause several diseases, including mitochondrial inherited diabetes and deafness (MIDD), typically…

  Authors: P B M de Andrade, B Rubi, F Frigerio, J M W van den Ouweland, J A Maassen, P Maechler

  Source: Diabetologia. 2006 Aug

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• Variants of CDKAL1 and IGF2BP2 affect first-phase insulin secretion during hyperglycaemic clamps.

  AIMS/HYPOTHESIS: Genome-wide association studies have recently identified novel type 2 diabetes susceptibility gene regions. We assessed the effects o…

  Authors: M J Groenewoud, J M Dekker, A Fritsche, E Reiling, G Nijpels, R J Heine, J A Maassen, F Machicao, S A Schäfer, H U Häring,…

  Source: Diabetologia. 2008 Sep

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• Genetic association analysis of LARS2 with type 2 diabetes.

  AIMS/HYPOTHESIS: LARS2 has been previously identified as a potential type 2 diabetes susceptibility gene through the low-frequency H324Q (rs71645922) …

  Authors: E Reiling, B Jafar-Mohammadi, E van 't Riet, M N Weedon, J V van Vliet-Ostaptchouk, T Hansen, R Saxena, T W van Haeften, P A Arp, S Das,…

  Source: Diabetologia. 2010 Jan

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• Mitochondrial dysfunction in adipocytes: the culprit in type 2 diabetes?

  Authors: J A Maassen

  Source: Diabetologia. 2006 Apr

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• Cardiac dysfunction induced by high-fat diet is associated with altered myocardial insulin signalling in rats.

  AIMS/HYPOTHESIS: Diabetic cardiomyopathy (DCM) is common in type 2 diabetes. In DCM, insulin resistance may alter cardiac substrate supply and utilisa…

  Authors: D M Ouwens, C Boer, M Fodor, P de Galan, R J Heine, J A Maassen, M Diamant

  Source: Diabetologia. 2005 Jun

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• Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice.

  AIMS/HYPOTHESIS: Activation of nutrient sensing through mammalian target of rapamycin (mTOR) has been linked to the pathogenesis of insulin resistance…

  Authors: E Korsheninnikova, G C M van der Zon, P J Voshol, G M Janssen, L M Havekes, A Grefhorst, F Kuipers, D-J Reijngoud, J A Romijn, D M Ouwens,…

  Source: Diabetologia. 2006 Dec

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