1 to 5 of 5 literature results

• Rare chromosomal deletions and duplications increase risk of schizophrenia.

  Schizophrenia is a severe mental disorder marked by hallucinations, delusions, cognitive deficits and apathy, with a heritability estimated at 73-90% …

  Authors: International Schizophrenia Consortium

  Source: Nature. 2008 Sep 11

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• Common polygenic variation contributes to risk of schizophrenia and bipolar disorder.

  Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by hallucinations, delusions and cognitive deficits, with he…

  Authors: International Schizophrenia Consortium, Shaun M Purcell, Naomi R Wray, Jennifer L Stone, Peter M Visscher, Michael C O'Donovan, Patrick F Sullivan, Pamela Sklar

  Source: Nature. 2009 Aug 6

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• Support for the involvement of large copy number variants in the pathogenesis of schizophrenia.

  We investigated the involvement of rare (<1%) copy number variants (CNVs) in 471 cases of schizophrenia and 2792 controls that had been genotyped usin…

  Authors: George Kirov, Detelina Grozeva, Nadine Norton, Dobril Ivanov, Kiran K Mantripragada, Peter Holmans, International Schizophrenia Consortium, Wellcome Trust Case Control Consortium, Nick Craddock, Michael J Owen,…

  Source: Human molecular genetics. 2009 Apr 15

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• Replicated genetic evidence supports a role for HOMER2 in schizophrenia.

  Schizophrenia is a heritable mental disorder with a complex genetic aetiology potentially implicating glutamatergic dysfunction. Following a search fo…

  Authors: William P Gilks, Emma H Allott, Gary Donohoe, Elizabeth Cummings, International Schizophrenia Consortium, Michael Gill, Aiden P Corvin, Derek W Morris

  Source: Neuroscience letters. 2010 Jan 14

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• Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.

  Translating a set of disease regions into insight about pathogenic mechanisms requires not only the ability to identify the key disease genes within t…

  Authors: Soumya Raychaudhuri, Robert M Plenge, Elizabeth J Rossin, Aylwin C Y Ng, International Schizophrenia Consortium, Shaun M Purcell, Pamela Sklar, Edward M Scolnick, Ramnik J Xavier, David Altshuler,…

  Source: PLoS genetics. 2009 Jun

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