1 to 10 of 17 literature results

• Rare chromosomal deletions and duplications increase risk of schizophrenia.

  Schizophrenia is a severe mental disorder marked by hallucinations, delusions, cognitive deficits and apathy, with a heritability estimated at 73-90% …

  Authors: International Schizophrenia Consortium

  Source: Nature. 2008 Sep 11

  View Full Text

• Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs.

  Schizophrenia is a complex disorder caused by both genetic and environmental factors. Using 9,087 affected individuals, 12,171 controls and 915,354 im…

  Authors: S Hong Lee, Teresa R DeCandia, Stephan Ripke, Jian Yang, Schizophrenia Psychiatric Genome-Wide Association Study Consortium (PGC-SCZ), International Schizophrenia Consortium (ISC), Molecular Genetics of Schizophrenia Collaboration (MGS), Patrick F Sullivan, Michael E Goddard, Matthew C Keller,…

  Source: Nature genetics. 2012 Mar

  View Full Text

• Common polygenic variation contributes to risk of schizophrenia and bipolar disorder.

  Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by hallucinations, delusions and cognitive deficits, with he…

  Authors: International Schizophrenia Consortium, Shaun M Purcell, Naomi R Wray, Jennifer L Stone, Peter M Visscher, Michael C O'Donovan, Patrick F Sullivan, Pamela Sklar

  Source: Nature. 2009 Aug 6

  View Full Text

• A bias-reducing pathway enrichment analysis of genome-wide association data confirmed association of the MHC region with schizophrenia.

  After the recent successes of genome-wide association studies (GWAS), one key challenge is to identify genetic variants that might have a significant …

  Authors: Peilin Jia, Lily Wang, Ayman H Fanous, Xiangning Chen, Kenneth S Kendler, International Schizophrenia Consortium, Zhongming Zhao

  Source: Journal of medical genetics. 2012 Feb

  View Full Text

• Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility.

  Susceptibility to schizophrenia and bipolar disorder may involve a substantial, shared contribution from thousands of common genetic variants, each of…

  Authors: C O'Dushlaine, E Kenny, E Heron, G Donohoe, M Gill, D Morris, International Schizophrenia Consortium, A Corvin

  Source: Molecular psychiatry. 2011 Mar

  View Full Text

• Schizophrenia susceptibility alleles are enriched for alleles that affect gene expression in adult human brain.

  It is widely thought that alleles that influence susceptibility to common diseases, including schizophrenia, will frequently do so through effects on …

  Authors: A L Richards, L Jones, V Moskvina, G Kirov, P V Gejman, D F Levinson, A R Sanders, Molecular Genetics of Schizophrenia Collaboration (MGS), International Schizophrenia Consortium (ISC), S Purcell,…

  Source: Molecular psychiatry. 2012 Feb

  View Full Text

• Hypothesis-driven candidate genes for schizophrenia compared to genome-wide association results.

  Candidate gene studies have been a key approach to the genetics of schizophrenia (SCZ). However, the results of these studies are confusing and no gen…

  Authors: A L Collins, Y Kim, P Sklar, International Schizophrenia Consortium, M C O'Donovan, P F Sullivan

  Source: Psychological medicine. 2012 Mar

  View Full Text

• Support for the involvement of large copy number variants in the pathogenesis of schizophrenia.

  We investigated the involvement of rare (<1%) copy number variants (CNVs) in 471 cases of schizophrenia and 2792 controls that had been genotyped usin…

  Authors: George Kirov, Detelina Grozeva, Nadine Norton, Dobril Ivanov, Kiran K Mantripragada, Peter Holmans, International Schizophrenia Consortium, Wellcome Trust Case Control Consortium, Nick Craddock, Michael J Owen,…

  Source: Human molecular genetics. 2009 Apr 15

  View Free Full Text

• Replicated genetic evidence supports a role for HOMER2 in schizophrenia.

  Schizophrenia is a heritable mental disorder with a complex genetic aetiology potentially implicating glutamatergic dysfunction. Following a search fo…

  Authors: William P Gilks, Emma H Allott, Gary Donohoe, Elizabeth Cummings, International Schizophrenia Consortium, Michael Gill, Aiden P Corvin, Derek W Morris

  Source: Neuroscience letters. 2010 Jan 14

  View Full Text

• Two non-synonymous markers in PTPN21, identified by genome-wide association study data-mining and replication, are associated with schizophrenia.

  We conducted data-mining analyses of genome wide association (GWA) studies of the CATIE and MGS-GAIN datasets, and found 13 markers in the two physica…

  Authors: Jingchun Chen, Grace Lee, Ayman H Fanous, Zhongming Zhao, Peilin Jia, Anthony O'Neill, Dermot Walsh, Kenneth S Kendler, Xiangning Chen, International Schizophrenia Consortium

  Source: Schizophrenia research. 2011 Sep

  View Full Text