1 to 8 of 8 literature results

• Rare chromosomal deletions and duplications increase risk of schizophrenia.

  Schizophrenia is a severe mental disorder marked by hallucinations, delusions, cognitive deficits and apathy, with a heritability estimated at 73-90% …

  Authors: International Schizophrenia Consortium

  Source: Nature. 2008 Sep 11

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• Common polygenic variation contributes to risk of schizophrenia and bipolar disorder.

  Schizophrenia is a severe mental disorder with a lifetime risk of about 1%, characterized by hallucinations, delusions and cognitive deficits, with he…

  Authors: International Schizophrenia Consortium, Shaun M Purcell, Naomi R Wray, Jennifer L Stone, Peter M Visscher, Michael C O'Donovan, Patrick F Sullivan, Pamela Sklar

  Source: Nature. 2009 Aug 6

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• Support for the involvement of large copy number variants in the pathogenesis of schizophrenia.

  We investigated the involvement of rare (<1%) copy number variants (CNVs) in 471 cases of schizophrenia and 2792 controls that had been genotyped usin…

  Authors: George Kirov, Detelina Grozeva, Nadine Norton, Dobril Ivanov, Kiran K Mantripragada, Peter Holmans, International Schizophrenia Consortium, Wellcome Trust Case Control Consortium, Nick Craddock, Michael J Owen,…

  Source: Human molecular genetics. 2009 Apr 15

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• Replicated genetic evidence supports a role for HOMER2 in schizophrenia.

  Schizophrenia is a heritable mental disorder with a complex genetic aetiology potentially implicating glutamatergic dysfunction. Following a search fo…

  Authors: William P Gilks, Emma H Allott, Gary Donohoe, Elizabeth Cummings, International Schizophrenia Consortium, Michael Gill, Aiden P Corvin, Derek W Morris

  Source: Neuroscience letters. 2010 Jan 14

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• Fine mapping of ZNF804A and genome-wide significant evidence for its involvement in schizophrenia and bipolar disorder.

  A recent genome-wide association study (GWAS) reported evidence for association between rs1344706 within ZNF804A (encoding zinc-finger protein 804A) a…

  Authors: H J Williams, N Norton, S Dwyer, V Moskvina, I Nikolov, L Carroll, L Georgieva, N M Williams, D W Morris, E M Quinn,…

  Source: Molecular psychiatry. 2010 Apr 6

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• Population structure and genome-wide patterns of variation in Ireland and Britain.

  Located off the northwestern coast of the European mainland, Britain and Ireland were among the last regions of Europe to be colonized by modern human…

  Authors: Colm T O'Dushlaine, Derek Morris, Valentina Moskvina, George Kirov, International Schizophrenia Consortium, Michael Gill, Aiden Corvin, James F Wilson, Gianpiero L Cavalleri

  Source: European journal of human genetics : EJHG. 2010 Jun 23

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• Further investigation of the association between rs7341475 and rs17746501 and schizophrenia.

  Genome-wide association studies (GWAS) with small sample size have had limited statistical power in identifying schizophrenia susceptibility genes. Th…

  Authors: Eyal Ben-David, Sagiv Shifman, International Schizophrenia Consortium

  Source: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. 2010 Sep

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• Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions.

  Translating a set of disease regions into insight about pathogenic mechanisms requires not only the ability to identify the key disease genes within t…

  Authors: Soumya Raychaudhuri, Robert M Plenge, Elizabeth J Rossin, Aylwin C Y Ng, International Schizophrenia Consortium, Shaun M Purcell, Pamela Sklar, Edward M Scolnick, Ramnik J Xavier, David Altshuler,…

  Source: PLoS genetics. 2009 Jun

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