1 to 10 of 34 literature results

• Dendritic cell immunotherapy: mapping the way.

  Dendritic cells (DCs) are the professional antigen-presenting cells of the immune system, with the potential to either stimulate or inhibit immune res…

  Authors: Carl G Figdor, I Jolanda M de Vries, W Joost Lesterhuis, Cornelis J M Melief

  Source: Nature medicine. 2004 May

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• Targeting DCIR on human plasmacytoid dendritic cells results in antigen presentation and inhibits IFN-alpha production.

  C-type lectin receptors (CLRs) fulfill multiple functions within the immune system by recognition of carbohydrate moieties on foreign or (altered) sel…

  Authors: Friederike Meyer-Wentrup, Daniel Benitez-Ribas, Paul J Tacken, Cornelis J A Punt, Carl G Figdor, I Jolanda M de Vries, Gosse J Adema

  Source: Blood. 2008 Apr 15

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• Migration of dendritic cell based cancer vaccines: in vivo veritas?

  Ex vivo generated cancer vaccines based on dendritic cells (DCs) are currently applied in the clinic. The migration of DCs from the tissues to the lym…

  Authors: Gosse J Adema, I Jolanda M de Vries, Cornelis J A Punt, Carl G Figdor

  Source: Current opinion in immunology. 2005 Apr

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• Magnetic resonance tracking of dendritic cells in melanoma patients for monitoring of cellular therapy.

  The success of cellular therapies will depend in part on accurate delivery of cells to target organs. In dendritic cell therapy, in particular, delive…

  Authors: I Jolanda M de Vries, W Joost Lesterhuis, Jelle O Barentsz, Pauline Verdijk, J Han van Krieken, Otto C Boerman, Wim J G Oyen, Johannes J Bonenkamp, Jan B Boezeman, Gosse J Adema,…

  Source: Nature biotechnology. 2005 Nov

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• In situ expression of tumor antigens by messenger RNA-electroporated dendritic cells in lymph nodes of melanoma patients.

  Electroporation of dendritic cells (DC) with mRNA encoding tumor-associated antigens (TAA) for cancer immunotherapy has been proved efficient and clin…

  Authors: Danita H Schuurhuis, Pauline Verdijk, Gerty Schreibelt, Erik H J G Aarntzen, Nicole Scharenborg, Annemiek de Boer, Mandy W M M van de Rakt, Marieke Kerkhoff, Marie-Jeanne P Gerritsen, Femke Eijckeler,…

  Source: Cancer research. 2009 Apr 1

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• DCIR is endocytosed into human dendritic cells and inhibits TLR8-mediated cytokine production.

  C-type lectin receptors (CLRs) expressed on APCs play a pivotal role in the immune system as pattern-recognition and antigen-uptake receptors. In addi…

  Authors: Friederike Meyer-Wentrup, Alessandra Cambi, Ben Joosten, Maaike W Looman, I Jolanda M de Vries, Carl G Figdor, Gosse J Adema

  Source: Journal of leukocyte biology. 2009 Mar

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• Effective induction of naive and recall T-cell responses by targeting antigen to human dendritic cells via a humanized anti-DC-SIGN antibody.

  Current dendritic cell (DC)-based vaccines are based on ex vivo-generated autologous DCs loaded with antigen prior to readministration into patients. …

  Authors: Paul J Tacken, I Jolanda M de Vries, Karlijn Gijzen, Ben Joosten, Dayang Wu, Russell P Rother, Susan J Faas, Cornelis J A Punt, Ruurd Torensma, Gosse J Adema,…

  Source: Blood. 2005 Aug 15

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• Regulatory T cells and the PD-L1/PD-1 pathway mediate immune suppression in malignant human brain tumors.

  The brain is a specialized immune site representing a unique tumor microenvironment. The availability of fresh brain tumor material for ex vivo analys…

  Authors: Joannes F M Jacobs, Albert J Idema, Kalijn F Bol, Stefan Nierkens, Oliver M Grauer, Pieter Wesseling, J André Grotenhuis, Peter M Hoogerbrugge, I Jolanda M de Vries, Gosse J Adema

  Source: Neuro-oncology. 2009 Aug

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• Toll-like receptor signalling on Tregs: to suppress or not to suppress?

  To balance self-tolerance and immunity against pathogens or tumours, the immune system depends on both activation mechanisms and down-regulatory mecha…

  Authors: Wendy W C van Maren, Joannes F M Jacobs, I Jolanda M de Vries, Stefan Nierkens, Gosse J Adema

  Source: Immunology. 2008 Aug

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• Maximizing dendritic cell migration in cancer immunotherapy.

  BACKGROUND: The success of dendritic cell (DC)-based immunotherapy in inducing cellular immunity against tumors is highly dependent on accurate delive…

  Authors: Pauline Verdijk, Erik H J G Aarntzen, Cornelis J A Punt, I Jolanda M de Vries, Carl G Figdor

  Source: Expert opinion on biological therapy. 2008 Jul

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