1 to 10 of 16 literature results

• Schizophrenia genetics: advancing on two fronts.

  Recent studies have supported the hypothesis that the high heritability of schizophrenia reflects a combination of relatively common alleles of small …

  Authors: Michael J Owen, Hywel J Williams, Michael C O'Donovan

  Source: Current opinion in genetics & development. 2009 Jun

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• A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain.

  The gene encoding catechol-O-methyltransferase (COMT) is a strong candidate for schizophrenia susceptibility, owing to the role of COMT in dopamine me…

  Authors: Nicholas J Bray, Paul R Buckland, Nigel M Williams, Hywel J Williams, Nadine Norton, Michael J Owen, Michael C O'Donovan

  Source: American journal of human genetics. 2003 Jul

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• Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches.

  BACKGROUND: Pharmacogenomic approaches based on genomewide sets of single nucleotide polymorphisms (SNPs) are now feasible and offer the potential to …

  Authors: Masashi Ikeda, Yasuyuki Tomita, Akihiro Mouri, Minori Koga, Tomo Okochi, Reiji Yoshimura, Yoshio Yamanouchi, Yoko Kinoshita, Ryota Hashimoto, Hywel J Williams,…

  Source: Biological psychiatry. 2010 Feb 1

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• Schizophrenia genetics: new insights from new approaches.

  INTRODUCTION: Schizophrenia is a debilitating psychiatric disorder that imposes a considerable burden on sufferers, their families and society. The pr…

  Authors: Hywel J Williams, Michael J Owen, Michael C O'Donovan

  Source: British medical bulletin. 2009

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• New findings from genetic association studies of schizophrenia.

  In the past 20 years, association studies of schizophrenia have evolved from analyses in lesser than 100 subjects of one or two markers in candidate g…

  Authors: Hywel J Williams, Michael J Owen, Michael C O'Donovan

  Source: Journal of human genetics. 2009 Jan

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• Association analysis of AKT1 and schizophrenia in a UK case control sample.

  AKT1 (V-akt murine thyoma viral oncogene homolog 1) is involved in intracellular signalling pathways postulated as of aetiological importance in schiz…

  Authors: Nadine Norton, Hywel J Williams, Sarah Dwyer, Liam Carroll, Tim Peirce, Valentina Moskvina, Ricardo Segurado, Ivan Nikolov, Nigel M Williams, Masashi Ikeda,…

  Source: Schizophrenia research. 2007 Jul

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• Is COMT a susceptibility gene for schizophrenia?

  Catechol-O-methyl transferase (COMT) is a catabolic enzyme involved in the degradation of a number of bioactive molecules; of principal interest to ps…

  Authors: Hywel J Williams, Michael J Owen, Michael C O'Donovan

  Source: Schizophrenia bulletin. 2007 May

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• No association between the putative functional ZDHHC8 single nucleotide polymorphism rs175174 and schizophrenia in large European samples.

  BACKGROUND: It has been recently reported that a functional variant in the ZDHHC8 gene encoding a putative palmitoyltransferase directly confers susce…

  Authors: Beate Glaser, Johannes Schumacher, Hywel J Williams, Rami Abou Jamra, Nikolai Ianakiev, Radoi Milev, Stephanie Ohlraun, Thomas G Schulze, Piotr M Czerski, Joanna Hauser,…

  Source: Biological psychiatry. 2005 Jul 1

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• Support for RGS4 as a susceptibility gene for schizophrenia.

  BACKGROUND: The gene encoding the regulator of G-protein signaling 4 has recently been associated with susceptibility to schizophrenia. This finding i…

  Authors: Nigel M Williams, Anna Preece, Gillian Spurlock, Nadine Norton, Hywel J Williams, Robin G McCreadie, Paul Buckland, Val Sharkey, Kodavali V Chowdari, Stanley Zammit,…

  Source: Biological psychiatry. 2004 Jan 15

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• Further evidence for the association of MMP9 with nephropathy in type 2 diabetes and application of DNA pooling technology to candidate gene screening.

  BACKGROUND: Diabetic nephropathy is characterised by extracellular matrix (ECM) expansion, a key modulator of which is TGF-b1. Glucose-stimulated tran…

  Authors: Sunita Nair, Aled O Phillips, Nadine Norton, Gillian Spurlock, Hywel J Williams, Kathrine J Craig, John D Williams, Nigel M Williams, Timothy Bowen

  Source: Journal of nephrology. 2008 May-Jun

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