1 to 10 of 26 literature results

• RNA interference and inhibition of MEK-ERK signaling prevent abnormal skeletal phenotypes in a mouse model of craniosynostosis.

  Premature fusion of one or more of the cranial sutures (craniosynostosis) in humans causes over 100 skeletal diseases, which occur in 1 of approximate…

  Authors: Vivek Shukla, Xavier Coumoul, Rui-Hong Wang, Hyun-Seok Kim, Chu-Xia Deng

  Source: Nature genetics. 2007 Sep

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• Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice.

  In lower eukaryotes, Sir2 serves as a histone deacetylase and is implicated in chromatin silencing, longevity, and genome stability. Here we mutated t…

  Authors: Rui-Hong Wang, Kundan Sengupta, Cuiling Li, Hyun-Seok Kim, Liu Cao, Cuiying Xiao, Sangsoo Kim, Xiaoling Xu, Yin Zheng, Beverly Chilton,…

  Source: Cancer cell. 2008 Oct 7

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• SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress.

  The sirtuin gene family (SIRT) is hypothesized to regulate the aging process and play a role in cellular repair. This work demonstrates that SIRT3(-/-…

  Authors: Hyun-Seok Kim, Krish Patel, Kristi Muldoon-Jacobs, Kheem S Bisht, Nukhet Aykin-Burns, J Daniel Pennington, Riet van der Meer, Phuongmai Nguyen, Jason Savage, Kjerstin M Owens,…

  Source: Cancer cell. 2010 Jan 19

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• Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis.

  Germline mutations of BRCA1 predispose women to breast and ovarian cancers. However, the downstream mediators of BRCA1 function in tumor suppression r…

  Authors: Rui-Hong Wang, Yin Zheng, Hyun-Seok Kim, Xiaoling Xu, Liu Cao, Tyler Luhasen, Mi-Hye Lee, Cuiying Xiao, Athanassios Vassilopoulos, Weiping Chen,…

  Source: Molecular cell. 2008 Oct 10

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• A combined-cross analysis reveals genes with drug-specific and background-dependent effects on drug sensitivity in Saccharomyces cerevisiae.

  Effective pharmacological therapy is often inhibited by variable drug responses and adverse drug reactions. Dissecting the molecular basis of differen…

  Authors: Hyun Seok Kim, Justin C Fay

  Source: Genetics. 2009 Nov

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• Laser drilling of nano-pores in sandwiched thin glass membranes.

  We report on a novel method of using an excimer laser to drill ultra-small pores in borosilicate glass membranes. By introducing a thin layer of liqui…

  Authors: Minrui Yu, Hyun-Seok Kim, Robert H Blick

  Source: Optics express. 2009 Jun 8

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• Characterization of acetylated corn starch prepared under ultrahigh pressure (UHP).

  To investigate the impact of ultrahigh pressure (UHP) on the physicochemical properties of the UHP-assisted starch acetate, common corn starch was sub…

  Authors: Hyun-Seok Kim, Hyun-Shik Choi, Byung-Yong Kim, Moo-Yeol Baik

  Source: Journal of agricultural and food chemistry. 2010 Mar 24

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• Radiosensitivity enhancement by celecoxib, a cyclooxygenase (COX)-2 selective inhibitor, via COX-2-dependent cell cycle regulation on human cancer cells expressing differential COX-2 levels.

  To characterize the radiation-enhancing effects on human cancer cells and underlying mechanisms of celecoxib, a cyclooxygenase (COX)-2 selective inhib…

  Authors: You Keun Shin, Ji Sun Park, Hyun Seok Kim, Hyun Jung Jun, Gwi Eon Kim, Chang Ok Suh, Yeon Sook Yun, Hongryull Pyo

  Source: Cancer research. 2005 Oct 15

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• Association of -31T>C and -511 C>T polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients.

  PURPOSE: To investigate the genetic association between unrelated Korean keratoconus patients and interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B…

  Authors: So-Hee Kim, Jee-Won Mok, Hyun-Seok Kim, C K Joo

  Source: Molecular vision. 2008

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• Actual and potential transpiration and carbon assimilation in an irrigated poplar plantation.

  We examined the tradeoffs between stand-level water use and carbon uptake that result when biomass production of trees in plantations is maximized by …

  Authors: Hyun-Seok Kim, Ram Oren, Thomas M Hinckley

  Source: Tree physiology. 2008 Apr

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