1 to 10 of 22 literature results

• Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance.

  Obesity caused by feeding of a high-fat diet (HFD) is associated with an increased activation of c-Jun NH(2)-terminal kinase 1 (JNK1). Activated JNK1 …

  Authors: Guadalupe Sabio, Norman J Kennedy, Julie Cavanagh-Kyros, Dae Young Jung, Hwi Jin Ko, Helena Ong, Tamera Barrett, Jason K Kim, Roger J Davis

  Source: Molecular and cellular biology. 2010 Jan

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• Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1.

  The cJun N-terminal kinase 1 (JNK1) is implicated in diet-induced obesity. Indeed, germline ablation of the murine Jnk1 gene prevents diet-induced obe…

  Authors: Guadalupe Sabio, Julie Cavanagh-Kyros, Tamera Barrett, Dae Young Jung, Hwi Jin Ko, Helena Ong, Caroline Morel, Alfonso Mora, Judith Reilly, Jason K Kim,…

  Source: Genes & development. 2010 Feb 1

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• Nutrient stress activates inflammation and reduces glucose metabolism by suppressing AMP-activated protein kinase in the heart.

  OBJECTIVE: Heart failure is a major cause of mortality in diabetes and may be causally associated with altered metabolism. Recent reports indicate a r…

  Authors: Hwi Jin Ko, Zhiyou Zhang, Dae Young Jung, John Y Jun, Zhexi Ma, Kelly E Jones, Sook Y Chan, Jason K Kim

  Source: Diabetes. 2009 Nov

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• Grp78 heterozygosity promotes adaptive unfolded protein response and attenuates diet-induced obesity and insulin resistance.

  OBJECTIVE: To investigate the role of the endoplasmic reticulum (ER) chaperone glucose-regulated protein (GRP) 78/BiP in the pathogenesis of obesity, …

  Authors: Risheng Ye, Dae Young Jung, John Y Jun, Jianze Li, Shengzhan Luo, Hwi Jin Ko, Jason K Kim, Amy S Lee

  Source: Diabetes. 2010 Jan

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• Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice.

  OBJECTIVE: Fibroblast growth factor 21 (FGF21) has emerged as an important metabolic regulator of glucose and lipid metabolism. The aims of the curren…

  Authors: Jing Xu, David J Lloyd, Clarence Hale, Shanaka Stanislaus, Michelle Chen, Glenn Sivits, Steven Vonderfecht, Randy Hecht, Yue-Sheng Li, Richard A Lindberg,…

  Source: Diabetes. 2009 Jan

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• Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues.

  OBJECTIVE: Skeletal muscle-specific LPL knockout mouse (SMLPL(-/-)) were created to study the systemic impact of reduced lipoprotein lipid delivery in…

  Authors: Hong Wang, Leslie A Knaub, Dalan R Jensen, Dae Young Jung, Eun-Gyoung Hong, Hwi-Jin Ko, Alison M Coates, Ira J Goldberg, Becky A de la Houssaye, Rachel C Janssen,…

  Source: Diabetes. 2009 Jan

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• Real-time monitoring of odorant-induced cellular reactions using surface plasmon resonance.

  Surface plasmon resonance (SPR) is a powerful technique for measuring molecular interaction in real-time. SPR can be used to detect molecule to cell i…

  Authors: Sang Hun Lee, Hwi Jin Ko, Tai Hyun Park

  Source: Biosensors & bioelectronics. 2009 Sep 15

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• Improved glucose homeostasis in mice with muscle-specific deletion of protein-tyrosine phosphatase 1B.

  Obesity and type 2 diabetes are characterized by insulin resistance. Mice lacking the protein-tyrosine phosphatase PTP1B in all tissues are hypersensi…

  Authors: Mirela Delibegovic, Kendra K Bence, Nimesh Mody, Eun-Gyoung Hong, Hwi Jin Ko, Jason K Kim, Barbara B Kahn, Benjamin G Neel

  Source: Molecular and cellular biology. 2007 Nov

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• Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle.

  OBJECTIVE: Insulin resistance is a major characteristic of type 2 diabetes and is causally associated with obesity. Inflammation plays an important ro…

  Authors: Eun-Gyoung Hong, Hwi Jin Ko, You-Ree Cho, Hyo-Jeong Kim, Zhexi Ma, Tim Y Yu, Randall H Friedline, Evelyn Kurt-Jones, Robert Finberg, Matthew A Fischer,…

  Source: Diabetes. 2009 Nov

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• Enhancement of odorant detection sensitivity by the expression of odorant-binding protein.

  Odorant-binding proteins are low molecular weight, soluble proteins that are secreted by glands of the nasal cavity. Their function is known to be the…

  Authors: Hwi Jin Ko, Tai Hyun Park

  Source: Biosensors & bioelectronics. 2008 Feb 28

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