1 to 10 of 14 literature results

• 53BP1 facilitates long-range DNA end-joining during V(D)J recombination.

  Variable, diversity and joining (V(D)J) recombination and class-switch recombination use overlapping but distinct non-homologous end joining pathways …

  Authors: Simone Difilippantonio, Eric Gapud, Nancy Wong, Ching-Yu Huang, Grace Mahowald, Hua Tang Chen, Michael J Kruhlak, Elsa Callen, Ferenc Livak, Michel C Nussenzweig,…

  Source: Nature. 2008 Nov 27

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• Role of genomic instability and p53 in AID-induced c-myc-Igh translocations.

  Chromosomal translocations involving the immunoglobulin switch region are a hallmark feature of B-cell malignancies. However, little is known about th…

  Authors: Almudena R Ramiro, Mila Jankovic, Elsa Callen, Simone Difilippantonio, Hua-Tang Chen, Kevin M McBride, Thomas R Eisenreich, Junjie Chen, Ross A Dickins, Scott W Lowe,…

  Source: Nature. 2006 Mar 2

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• AID is required for the chromosomal breaks in c-myc that lead to c-myc/IgH translocations.

  Chromosomal translocation requires formation of paired double-strand DNA breaks (DSBs) on heterologous chromosomes. One of the most well characterized…

  Authors: Davide F Robbiani, Anne Bothmer, Elsa Callen, Bernardo Reina-San-Martin, Yair Dorsett, Simone Difilippantonio, Daniel J Bolland, Hua Tang Chen, Anne E Corcoran, André Nussenzweig,…

  Source: Cell. 2008 Dec 12

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• 53BP1 inhibits homologous recombination in Brca1-deficient cells by blocking resection of DNA breaks.

  Defective DNA repair by homologous recombination (HR) is thought to be a major contributor to tumorigenesis in individuals carrying Brca1 mutations. H…

  Authors: Samuel F Bunting, Elsa Callén, Nancy Wong, Hua-Tang Chen, Federica Polato, Amanda Gunn, Anne Bothmer, Niklas Feldhahn, Oscar Fernandez-Capetillo, Liu Cao,…

  Source: Cell. 2010 Apr 16

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• Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes.

  The DNA double-strand break (DSB) repair protein DNA-PKcs and the signal transducer ATM are both activated by DNA breaks and phosphorylate similar sub…

  Authors: Elsa Callén, Mila Jankovic, Nancy Wong, Shan Zha, Hua-Tang Chen, Simone Difilippantonio, Michela Di Virgilio, Gordon Heidkamp, Frederick W Alt, André Nussenzweig,…

  Source: Molecular cell. 2009 May 15

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• ATM prevents the persistence and propagation of chromosome breaks in lymphocytes.

  DNA double-strand breaks (DSBs) induce a signal transmitted by the ataxia-telangiectasia mutated (ATM) kinase, which suppresses illegitimate joining o…

  Authors: Elsa Callén, Mila Jankovic, Simone Difilippantonio, Jeremy A Daniel, Hua-Tang Chen, Arkady Celeste, Manuela Pellegrini, Kevin McBride, Danny Wangsa, Andrea L Bredemeyer,…

  Source: Cell. 2007 Jul 13

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• Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.

  Nijmegen breakage syndrome (NBS) is a chromosomal fragility disorder that shares clinical and cellular features with ataxia telangiectasia. Here we de…

  Authors: Simone Difilippantonio, Arkady Celeste, Oscar Fernandez-Capetillo, Hua-Tang Chen, Bernardo Reina San Martin, Francois Van Laethem, Yong-Ping Yang, Galina V Petukhova, Michael Eckhaus, Lionel Feigenbaum,…

  Source: Nature cell biology. 2005 Jul

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• DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1.

  Activation of the ataxia telangiectasia mutated (ATM) kinase triggers diverse cellular responses to ionizing radiation (IR), including the initiation …

  Authors: Oscar Fernandez-Capetillo, Hua-Tang Chen, Arkady Celeste, Irene Ward, Peter J Romanienko, Julio C Morales, Kazuhito Naka, Zhenfang Xia, R Daniel Camerini-Otero, Noboru Motoyama,…

  Source: Nature cell biology. 2002 Dec

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• Knockout of Ku86 accelerates cellular senescence induced by high NaCl.

  NaCl induces DNA breaks, thus leading to cellular senescence. Here we showed that Ku86 deficiency accelerated the high NaCl-induced cellular senescenc…

  Authors: Natalia I Dmitrieva, Hua Tang Chen, André Nussenzweig, Maurice B Burg

  Source: Aging. 2009 Feb

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• Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8.

  53BP1 is a well-known mediator of the cellular response to DNA damage. Two alternative mechanisms have been proposed to explain 53BP1's interaction wi…

  Authors: Margarida Almeida Santos, Michael S Y Huen, Mila Jankovic, Hua-Tang Chen, Andrés J López-Contreras, Isaac A Klein, Nancy Wong, Juan L R Barbancho, Oscar Fernandez-Capetillo, Michel C Nussenzweig,…

  Source: The Journal of experimental medicine. 2010 May 10

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