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Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE.
Multiple sclerosis is an inflammatory disease of the central nervous system that begins as a relapsing-remitting disease (RRMS) and is followed by a p…
Authors: Mauricio F Farez, Francisco J Quintana, Roopali Gandhi, Guillermo Izquierdo, Miguel Lucas, Howard L Weiner
Source: Nature immunology. 2009 Sep
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The challenge of multiple sclerosis: how do we cure a chronic heterogeneous disease?
Multiple sclerosis is (MS) a T-cell autoimmune disease characterized by a relapsing-remitting followed by a progressive phase. Relapses are driven by …
Authors: Howard L Weiner
Source: Annals of neurology. 2009 Mar
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Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor.
Regulatory T cells (T(reg)) expressing the transcription factor Foxp3 control the autoreactive components of the immune system. The development of T(r…
Authors: Francisco J Quintana, Alexandre S Basso, Antonio H Iglesias, Thomas Korn, Mauricio F Farez, Estelle Bettelli, Mario Caccamo, Mohamed Oukka, Howard L Weiner
Source: Nature. 2008 May 1
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A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells.
Regulatory T cells (T(reg) cells) expressing the transcription factor Foxp3 are key in maintaining the balance of immune homeostasis. However, distinc…
Authors: Amit Awasthi, Yijun Carrier, Jean P S Peron, Estelle Bettelli, Masahito Kamanaka, Richard A Flavell, Vijay K Kuchroo, Mohamed Oukka, Howard L Weiner
Source: Nature immunology. 2007 Dec
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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.
On activation, T cells undergo distinct developmental pathways, attaining specialized properties and effector functions. T-helper (T(H)) cells are tra…
Authors: Estelle Bettelli, Yijun Carrier, Wenda Gao, Thomas Korn, Terry B Strom, Mohamed Oukka, Howard L Weiner, Vijay K Kuchroo
Source: Nature. 2006 May 11
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Inflammation and therapeutic vaccination in CNS diseases.
The spectrum of inflammatory diseases of the central nervous system has been steadily expanding from classical autoimmune disorders such as multiple s…
Authors: Howard L Weiner, Dennis J Selkoe
Source: Nature. 2002 Dec 19-26
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Oral CD3-specific antibody suppresses autoimmune encephalomyelitis by inducing CD4+ CD25- LAP+ T cells.
A major goal of immunotherapy for autoimmune diseases and transplantation is induction of regulatory T cells that mediate immunologic tolerance. The m…
Authors: Hirofumi Ochi, Michal Abraham, Hiroki Ishikawa, Dan Frenkel, Kaiyong Yang, Alexandre S Basso, Henry Wu, Mei-Ling Chen, Roopali Gandhi, Ariel Miller,…
Source: Nature medicine. 2006 Jun
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Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
We report the results of a meta-analysis of genome-wide association scans for multiple sclerosis (MS) susceptibility that includes 2,624 subjects with…
Authors: Philip L De Jager, Xiaoming Jia, Joanne Wang, Paul I W de Bakker, Linda Ottoboni, Neelum T Aggarwal, Laura Piccio, Soumya Raychaudhuri, Dong Tran, Cristin Aubin,…
Source: Nature genetics. 2009 Jul
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Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE.
Authors: Mauricio F Farez, Francisco J Quintana, Roopali Gandhi, Guillermo Izquierdo, Miguel Lucas, Howard L Weiner
Source: Nature immunology. 2010 Jan
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Environmental control of Th17 differentiation.
Th17 cells participate in the control of extracellular bacteria and fungi, but dysregulated Th17 cell activity can result in immunopathology. Thus, th…
Authors: Francisco J Quintana, Howard L Weiner
Source: European journal of immunology. 2009 Mar
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