1 to 10 of 20 literature results

• RAD18 transmits DNA damage signalling to elicit homologous recombination repair.

  To maintain genome stability, cells respond to DNA damage by activating signalling pathways that govern cell-cycle checkpoints and initiate DNA repair…

  Authors: Jun Huang, Michael S Y Huen, Hongtae Kim, Charles Chung Yun Leung, J N Mark Glover, Xiaochun Yu, Junjie Chen

  Source: Nature cell biology. 2009 May

  View Free Full Text

• High resolution X-ray phase contrast synchrotron imaging of normal and ligation damaged rat sciatic nerves.

  This study was performed to apply synchrotron radiation (SR) imaging to a neuropathologic evaluation technique after treatment of peripheral nerve blo…

  Authors: Bong-Il Kim, Ki-Hong Kim, Hwa-Shik Youn, Sanghoon Jheon, Jong-Ki Kim, Hongtae Kim

  Source: Microscopy research and technique. 2008 Jun

  View Full Text

• c-Myc interacts with TRF1/PIN2 and regulates telomere length.

  Telomere, the end of linear chromosome, is protected by DNA-protein complexes. These complexes cap the linear chromosome and play an important role in…

  Authors: Hongtae Kim, Junjie Chen

  Source: Biochemical and biophysical research communications. 2007 Nov 3

  View Free Full Text

• The merlin tumor suppressor interacts with Ral guanine nucleotide dissociation stimulator and inhibits its activity.

  Neurofibromatosis type 2 (NF2) is the most commonly mutated gene in benign tumors of the human nervous system such as schwannomas and meningiomas. The…

  Authors: Chung Hun Ryu, Sae-Woong Kim, Kyu Hwa Lee, Joo Yong Lee, Hongtae Kim, Woon Kyu Lee, Byung Hyune Choi, Young Lim, Young Hoon Kim, Kweon-Haeng Lee,…

  Source: Oncogene. 2005 Aug 11

  View Full Text

• New players in the BRCA1-mediated DNA damage responsive pathway.

  DNA damage checkpoint is an important self-defense mechanism for the maintenance of genome stability. Defects in DNA damage signaling and repair lead …

  Authors: Hongtae Kim, Junjie Chen

  Source: Molecules and cells. 2008 Jun 30

  View Full Text

• Merlin inhibits growth hormone-regulated Raf-ERKs pathways by binding to Grb2 protein.

  Numerous studies have suggested that the NF2 protein merlin is involved in the regulation of abnormal cell growth and proliferation. In this study, to…

  Authors: Jung Yeon Lim, Hongtae Kim, Sin-Soo Jeun, Seok-Gu Kang, Kyung-Jin Lee

  Source: Biochemical and biophysical research communications. 2006 Feb 24

  View Full Text

• Merlin suppresses the SRE-dependent transcription by inhibiting the activation of Ras-ERK pathway.

  The neurofibromatosis type 2 (NF2) gene encodes an intracellular membrane-associated protein called merlin or schwannomin, which is known to be a tumo…

  Authors: Jung Yeon Lim, Hongtae Kim, Young Hoon Kim, Sae Woong Kim, Pil-Woo Huh, Kweon-Haeng Lee, Sin-Soo Jeun, Hyoung Kyun Rha, Joon-ki Kang

  Source: Biochemical and biophysical research communications. 2003 Mar 7

  View Full Text

• MAP, a protein interacting with a tumor suppressor, merlin, through the run domain.

  Merlin (or schwannomin) is a tumor suppressor encoded by the neurofibromatosis type 2 gene. Many studies have suggested that merlin is involved in the…

  Authors: Il Kyu Lee, Kyung-Soo Kim, Hongtae Kim, Joo Yong Lee, Chung Hun Ryu, Heung Jae Chun, Kyoung-Uk Lee, Young Lim, Young Hoon Kim, Pil-Woo Huh,…

  Source: Biochemical and biophysical research communications. 2004 Dec 17

  View Full Text

• Amyloid beta peptide (Abeta42) activates PLC-delta1 promoter through the NF-kappaB binding site.

  The abnormal deposition of amyloid beta peptide (Abeta) is a hallmark of Alzheimer's disease (AD). Phospholipase C-delta1 (PLC-delta1) is also known t…

  Authors: Jin Young Kim, Hongtae Kim, Seok Geun Lee, Byung Hyune Choi, Young Hoon Kim, Pil-Woo Huh, Kweon-Haeng Lee, Hoon Han, Hyoung Kyun Rha

  Source: Biochemical and biophysical research communications. 2003 Oct 24

  View Full Text

• The linker connecting the tandem ubiquitin binding domains of RAP80 is critical for lysine 63-linked polyubiquitin-dependent binding activity.

  The tandem ubiquitin-interacting motif (UIM) domain located at the N-terminus of Receptor Associated Protein 80 (RAP80) plays a crucial role in ionizi…

  Authors: Hyun-Jung Cho, Sangho Lee, Hongtae Kim

  Source: BMB reports. 2009 Nov 30

  View Full Text