1 to 10 of 22 literature results

• Neutrophil elastase-mediated degradation of IRS-1 accelerates lung tumor growth.

  Lung cancer is the leading cause of cancer death worldwide. Recent data suggest that tumor-associated inflammatory cells may modify lung tumor growth …

  Authors: A McGarry Houghton, Danuta M Rzymkiewicz, Hongbin Ji, Alyssa D Gregory, Eduardo E Egea, Heather E Metz, Donna B Stolz, Stephanie R Land, Luiz A Marconcini, Corrine R Kliment,…

  Source: Nature medicine. 2010 Feb

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• LKB1 modulates lung cancer differentiation and metastasis.

  Germline mutation in serine/threonine kinase 11 (STK11, also called LKB1) results in Peutz-Jeghers syndrome, characterized by intestinal hamartomas an…

  Authors: Hongbin Ji, Matthew R Ramsey, D Neil Hayes, Cheng Fan, Kate McNamara, Piotr Kozlowski, Chad Torrice, Michael C Wu, Takeshi Shimamura, Samanthi A Perera,…

  Source: Nature. 2007 Aug 16

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• HLungDB: an integrated database of human lung cancer research.

  The human lung cancer database (HLungDB) is a database with the integration of the lung cancer-related genes, proteins and miRNAs together with the co…

  Authors: Lishan Wang, Yuanyuan Xiong, Yihua Sun, Zhaoyuan Fang, Li Li, Hongbin Ji, Tieliu Shi

  Source: Nucleic acids research. 2010 Jan

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• Bronchial and peripheral murine lung carcinomas induced by T790M-L858R mutant EGFR respond to HKI-272 and rapamycin combination therapy.

  The EGFR T790M mutation has been identified in tumors from lung cancer patients that eventually develop resistance to erlotinib. In this study, we gen…

  Authors: Danan Li, Takeshi Shimamura, Hongbin Ji, Liang Chen, Henry J Haringsma, Kate McNamara, Mei-Chih Liang, Samanthi A Perera, Sara Zaghlul, Christa L Borgman,…

  Source: Cancer cell. 2007 Jul

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• The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies.

  To understand the role of human epidermal growth factor receptor (hEGFR) kinase domain mutations in lung tumorigenesis and response to EGFR-targeted t…

  Authors: Hongbin Ji, Danan Li, Liang Chen, Takeshi Shimamura, Susumu Kobayashi, Kate McNamara, Umar Mahmood, Albert Mitchell, Yangping Sun, Ruqayyah Al-Hashem,…

  Source: Cancer cell. 2006 Jun

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• Hsp90 inhibition suppresses mutant EGFR-T790M signaling and overcomes kinase inhibitor resistance.

  The epidermal growth factor receptor (EGFR) secondary kinase domain T790M non-small cell lung cancer (NSCLC) mutation enhances receptor catalytic acti…

  Authors: Takeshi Shimamura, Danan Li, Hongbin Ji, Henry J Haringsma, Elizabeth Liniker, Christa L Borgman, April M Lowell, Yuko Minami, Kate McNamara, Samanthi A Perera,…

  Source: Cancer research. 2008 Jul 15

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• Colitis is associated with thymic destruction attenuating CD4+25+ regulatory T cells in the periphery.

  BACKGROUND & AIMS: Syngeneic bone marrow transplantation into the adult tgepsilon26 mouse results in severe wasting disease and colitis. On transplant…

  Authors: William A Faubion, Ype P De Jong, Ana Abadia Molina, Hongbin Ji, Kareem Clarke, Baoping Wang, Emiko Mizoguchi, Stephen J Simpson, Atul K Bhan, Cox Terhorst

  Source: Gastroenterology. 2004 Jun

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• Non-small-cell lung cancer and Ba/F3 transformed cells harboring the ERBB2 G776insV_G/C mutation are sensitive to the dual-specific epidermal growth factor receptor and ERBB2 inhibitor HKI-272.

  Mutation-specific cancer therapy has shown promising clinical efficacy. In non-small-cell lung cancer (NSCLC), the presence of mutations in the epider…

  Authors: Takeshi Shimamura, Hongbin Ji, Yuko Minami, Roman K Thomas, April M Lowell, Kinjal Shah, Heidi Greulich, Karen A Glatt, Matthew Meyerson, Geoffrey I Shapiro,…

  Source: Cancer research. 2006 Jul 1

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• An alternative inhibitor overcomes resistance caused by a mutation of the epidermal growth factor receptor.

  Mutations of the epidermal growth factor receptor (EGFR) gene have been identified in non-small cell lung cancer specimens from patients responding to…

  Authors: Susumu Kobayashi, Hongbin Ji, Yuki Yuza, Matthew Meyerson, Kwok-Kin Wong, Daniel G Tenen, Balázs Halmos

  Source: Cancer research. 2005 Aug 15

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• Mutations in BRAF and KRAS converge on activation of the mitogen-activated protein kinase pathway in lung cancer mouse models.

  Mutations in the BRAF and KRAS genes occur in approximately 1% to 2% and 20% to 30% of non-small-cell lung cancer patients, respectively, suggesting t…

  Authors: Hongbin Ji, Zhenxiong Wang, Samanthi A Perera, Danan Li, Mei-Chih Liang, Sara Zaghlul, Kate McNamara, Liang Chen, Mitchell Albert, Yanping Sun,…

  Source: Cancer research. 2007 May 15

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