1 to 10 of 365 literature results

• The Creb1 coactivator Crtc1 is required for energy balance and fertility.

  The adipocyte-derived hormone leptin maintains energy balance by acting on hypothalamic leptin receptors (Leprs) that act on the signal transducer and…

  Authors: Judith Y Altarejos, Naomi Goebel, Michael D Conkright, Hiroshi Inoue, Jianxin Xie, Carlos M Arias, Paul E Sawchenko, Marc Montminy

  Source: Nature medicine. 2008 Oct

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• Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-gamma phosphorylation.

  Insulin receptor substrate (IRS)-1 and IRS-2 have dominant roles in the action of insulin, but other substrates of the insulin receptor kinase, such a…

  Authors: Tetsuya Hosooka, Tetsuya Noguchi, Ko Kotani, Takehiro Nakamura, Hiroshi Sakaue, Hiroshi Inoue, Wataru Ogawa, Kazutoshi Tobimatsu, Kazuo Takazawa, Mashito Sakai,…

  Source: Nature medicine. 2008 Feb

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• Remote triggering of deep earthquakes in the 2002 Tonga sequences.

  It is well established that an earthquake in the Earth's crust can trigger subsequent earthquakes, but such triggering has not been documented for dee…

  Authors: Rigobert Tibi, Douglas A Wiens, Hiroshi Inoue

  Source: Nature. 2003 Aug 21

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• Recessive mutations in the putative calcium-activated chloride channel Anoctamin 5 cause proximal LGMD2L and distal MMD3 muscular dystrophies.

  The recently described human anion channel Anoctamin (ANO) protein family comprises at least ten members, many of which have been shown to correspond …

  Authors: Véronique Bolduc, Gareth Marlow, Kym M Boycott, Khalil Saleki, Hiroshi Inoue, Johan Kroon, Mitsuo Itakura, Yves Robitaille, Lucie Parent, Frank Baas,…

  Source: American journal of human genetics. 2010 Feb 12

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• Efficient identification of a novel cancer/testis antigen for immunotherapy using three-step microarray analysis.

  Advanced technology in molecular biology has provided us powerful tools for the diagnosis and treatment for cancer. We herein adopted a new methodolog…

  Authors: Takeshi Yokoe, Fumiaki Tanaka, Koshi Mimori, Hiroshi Inoue, Takahiro Ohmachi, Masato Kusunoki, Masaki Mori

  Source: Cancer research. 2008 Feb 15

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• Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo.

  The transcription factor, signal transducer and activator of transcription-3 (STAT-3) contributes to various physiological processes. Here we show tha…

  Authors: Hiroshi Inoue, Wataru Ogawa, Michitaka Ozaki, Sanae Haga, Michihiro Matsumoto, Kensuke Furukawa, Naoko Hashimoto, Yoshiaki Kido, Toshiyuki Mori, Hiroshi Sakaue,…

  Source: Nature medicine. 2004 Feb

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• Fhit-deficient hematopoietic stem cells survive hydroquinone exposure carrying precancerous changes.

  The fragile FHIT gene is among the first targets of DNA damage in preneoplastic lesions, and recent studies have shown that Fhit protein is involved i…

  Authors: Hideshi Ishii, Koshi Mimori, Kazuhiro Ishikawa, Hiroshi Okumura, Flavia Pichiorri, Teresa Druck, Hiroshi Inoue, Andrea Vecchione, Toshiyuki Saito, Masaki Mori,…

  Source: Cancer research. 2008 May 15

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• PGP9.5 methylation in diffuse-type gastric cancer.

  Diffuse-type gastric cancer (DGC) is the most deadly form of gastric cancer and is frequently accompanied by peritoneal dissemination and metastasis. …

  Authors: Keishi Yamashita, Hannah Lui Park, Myoung Sook Kim, Motonobu Osada, Yutaka Tokumaru, Hiroshi Inoue, Masaki Mori, David Sidransky

  Source: Cancer research. 2006 Apr 1

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• Restoration of glucokinase expression in the liver normalizes postprandial glucose disposal in mice with hepatic deficiency of PDK1.

  Phosphoinositide-dependent kinase-1 (PDK1) is implicated in the metabolic effects of insulin as a key mediator of phosphoinositide 3-kinase-dependent …

  Authors: Yasuo Okamoto, Wataru Ogawa, Akihiko Nishizawa, Hiroshi Inoue, Kiyoshi Teshigawara, Shinichi Kinoshita, Yasushi Matsuki, Eijiro Watanabe, Ryuji Hiramatsu, Hiroshi Sakaue,…

  Source: Diabetes. 2007 Apr

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• FHIT is up-regulated by inflammatory stimuli and inhibits prostaglandin E2-mediated cancer progression.

  The FHIT gene is known to be susceptible to environmental carcinogens. Formation of prostaglandin E(2) (PGE(2)) is catalyzed by cyclooxygenase-2 (COX-…

  Authors: Koshi Mimori, Hideshi Ishii, Hisashi Nagahara, Tomoya Sudo, Keishi Yamashita, Hiroshi Inoue, Graham F Barnard, Masaki Mori

  Source: Cancer research. 2006 Mar 1

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