1 to 10 of 154 literature results

• N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma.

  Studying the early stages of cancer can provide important insight into the molecular basis of the disease. We identified a preneoplastic stage in the …

  Authors: Jessica D Kessler, Hiroshi Hasegawa, Sonja N Brun, Brian A Emmenegger, Zeng-Jie Yang, John W Dutton, Fan Wang, Robert J Wechsler-Reya

  Source: Genes & development. 2009 Jan 15

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• G-CSF therapy for acute myocardial infarction.

  Granulocyte-colony-stimulating factor (G-CSF) has recently been shown to have various effects besides promoting the proliferation and differentiation …

  Authors: Hiroyuki Takano, Kazutaka Ueda, Hiroshi Hasegawa, Issei Komuro

  Source: Trends in pharmacological sciences. 2007 Oct

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• Restrictive left ventricular filling pattern does not result from increased left atrial pressure alone.

  BACKGROUND: The restrictive filling pattern seen with severe heart failure (HF) may be due to diastolic dysfunction with elevated left ventricular (LV…

  Authors: Satoshi Masutani, William C Little, Hiroshi Hasegawa, Heng-Jie Cheng, Che-Ping Cheng

  Source: Circulation. 2008 Mar 25

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• TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.

  The presenilin proteins (PS1 and PS2) and their interacting partners nicastrin, aph-1 (refs 4, 5) and pen-2 (ref. 5) form a series of high-molecular-m…

  Authors: Fusheng Chen, Hiroshi Hasegawa, Gerold Schmitt-Ulms, Toshitaka Kawarai, Christopher Bohm, Taiichi Katayama, Yongjun Gu, Nobuo Sanjo, Michael Glista, Ekaterina Rogaeva,…

  Source: Nature. 2006 Apr 27

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• G-CSF prevents cardiac remodeling after myocardial infarction by activating the Jak-Stat pathway in cardiomyocytes.

  Granulocyte colony-stimulating factor (G-CSF) was reported to induce myocardial regeneration by promoting mobilization of bone marrow stem cells to th…

  Authors: Mutsuo Harada, Yingjie Qin, Hiroyuki Takano, Tohru Minamino, Yunzeng Zou, Haruhiro Toko, Masashi Ohtsuka, Katsuhisa Matsuura, Masanori Sano, Jun-ichiro Nishi,…

  Source: Nature medicine. 2005 Mar

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• The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.

  The recycling of the amyloid precursor protein (APP) from the cell surface via the endocytic pathways plays a key role in the generation of amyloid be…

  Authors: Ekaterina Rogaeva, Yan Meng, Joseph H Lee, Yongjun Gu, Toshitaka Kawarai, Fanggeng Zou, Taiichi Katayama, Clinton T Baldwin, Rong Cheng, Hiroshi Hasegawa,…

  Source: Nature genetics. 2007 Feb

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• Cardioprotective effects of granulocyte colony-stimulating factor in swine with chronic myocardial ischemia.

  OBJECTIVES: The aim of this study was to investigate the effect of granulocyte colony-stimulating factor (G-CSF) on chronic myocardial ischemia in swi…

  Authors: Hiroshi Hasegawa, Hiroyuki Takano, Koji Iwanaga, Masashi Ohtsuka, Yingjie Qin, Yuriko Niitsuma, Kazutaka Ueda, Tomohiko Toyoda, Hiroyuki Tadokoro, Issei Komuro

  Source: Journal of the American College of Cardiology. 2006 Feb 21

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• Response of spinach and komatsuna to biogas effluent made from source-separated kitchen garbage.

  Recycling of kitchen garbage is an urgent task for reducing public spending and environmental burdens by incineration and/or landfill. There is an int…

  Authors: Yuichiro Furukawa, Hiroshi Hasegawa

  Source: Journal of environmental quality. 2006 Sep-Oct

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• Potent free radical scavenger, edaravone, suppresses oxidative stress-induced endothelial damage and early atherosclerosis.

  OBJECTIVE: Effects of potent free radical scavenger, edaravone, on oxidative stress-induced endothelial damage and early atherosclerosis were investig…

  Authors: Hang Xi, Masahiro Akishita, Kumiko Nagai, Wei Yu, Hiroshi Hasegawa, Masato Eto, Koichi Kozaki, Kenji Toba

  Source: Atherosclerosis. 2007 Apr

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• Seasonal dynamics of biodegradation activities for dimethylarsinic acid (DMA) in Lake Kahokugata.

  The microbial activities in aquatic environments significantly influence arsenic cycles such as the turnover between inorganic arsenic and organoarsen…

  Authors: Teruya Maki, Wakana Hirota, Kaori Ueda, Hiroshi Hasegawa, Mohammad Azizur Rahman

  Source: Chemosphere. 2009 Sep

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