1 to 10 of 16 literature results

• Mutations in the fatty acid 2-hydroxylase gene are associated with leukodystrophy with spastic paraparesis and dystonia.

  Myelination is a complex, developmentally regulated process whereby myelin proteins and lipids are coordinately expressed by myelinating glial cells. …

  Authors: Simon Edvardson, Hiroko Hama, Avraham Shaag, John Moshe Gomori, Itai Berger, Dov Soffer, Stanley H Korman, Ilana Taustein, Ann Saada, Orly Elpeleg

  Source: American journal of human genetics. 2008 Nov

  View Free Full Text

• Fatty acid 2-hydroxylase regulates cAMP-induced cell cycle exit in D6P2T schwannoma cells.

  Sphingolipids are ubiquitous components of eukaryotic cells that regulate various cellular functions. In many cell types, a fraction of sphingolipids …

  Authors: Nathan L Alderson, Hiroko Hama

  Source: Journal of lipid research. 2009 Jun

  View Full Text

• Loss of functional ELOVL4 depletes very long-chain fatty acids (> or =C28) and the unique omega-O-acylceramides in skin leading to neonatal death.

  Mutations in elongation of very long-chain fatty acid-4 (ELOVL4) are associated with autosomal dominant Stargardt-like macular degeneration (STGD3), w…

  Authors: Vidyullatha Vasireddy, Yoshikazu Uchida, Norman Salem, Soo Yeon Kim, Md Nawajesh Ali Mandal, Geereddy Bhanuprakash Reddy, Ravi Bodepudi, Nathan L Alderson, Johnie C Brown, Hiroko Hama,…

  Source: Human molecular genetics. 2007 Mar 1

  View Free Full Text

• FA2H is responsible for the formation of 2-hydroxy galactolipids in peripheral nervous system myelin.

  Myelin in the mammalian nervous system has a high concentration of galactolipids [galactosylceramide (GalCer) and sulfatide] with 2-hydroxy fatty acid…

  Authors: Eduardo N Maldonado, Nathan L Alderson, Paula V Monje, Patrick M Wood, Hiroko Hama

  Source: Journal of lipid research. 2008 Jan

  View Free Full Text

• FA2H-dependent fatty acid 2-hydroxylation in postnatal mouse brain.

  2-Hydroxy fatty acids are relatively minor species of membrane lipids found almost exclusively as N-acyl chains of sphingolipids. In mammals, 2-hydrox…

  Authors: Nathan L Alderson, Eduardo N Maldonado, Michael J Kern, Narayan R Bhat, Hiroko Hama

  Source: Journal of lipid research. 2006 Dec

  View Full Text

• A novel method for the measurement of in vitro fatty acid 2-hydroxylase activity by gas chromatography-mass spectrometry.

  Fatty acid 2-hydroxylase (FA2H), encoded by the FA2H gene, is an enzyme responsible for the de novo synthesis of sphingolipids containing 2-hydroxy fa…

  Authors: Nathan L Alderson, Michael D Walla, Hiroko Hama

  Source: Journal of lipid research. 2005 Jul

  View Full Text

• Involvement of protein kinase C-related anti-apoptosis signaling in radiation-induced apoptosis in murine thymic lymphoma(3SBH5) cells.

  Protein kinase C (PKC; also known as PRKC) is known to be an important participant in radiation-induced apoptosis. However, its role is not fully clar…

  Authors: Tetsuo Nakajima, Osami Yukawa, Chihiro Azuma, Harumi Ohyama, Bing Wang, Shuji Kojima, Isamu Hayata, Hiroko Hama-Inaba

  Source: Radiation research. 2004 May

  View Full Text

• Palliative care team in National Hospital Organization Osaka Minami Medical Center

  Preparation of a system of palliative care support is called for by The Basic Act on Anti-Cancer Measures and The Basic Plans for National Cancer Stra…

  Authors: Takashi Hama, Suguru Yamamoto, Satoru Sakaguchi, Fumihiko Nakanishi, Sachiko Uda, Shigefumi Morimoto, Akihiro Taji, Ikuko Ueda, Ayumi Kobayashi, Satsuki Noda,…

  Source: Gan to kagaku ryoho. Cancer & chemotherapy. 2009 May

  View Full Text

• Regulation of telomere length by fatty acid elongase 3 in yeast. Involvement of inositol phosphate metabolism and Ku70/80 function.

  In this study, we investigated the roles of very long-chain fatty acid (VLCFA) synthesis by fatty acid elongase 3 (ELO3) in the regulation of telomere…

  Authors: Suriyan Ponnusamy, Nathan L Alderson, Hiroko Hama, Jacek Bielawski, James C Jiang, Rashna Bhandari, Solomon H Snyder, S Michal Jazwinski, Besim Ogretmen

  Source: The Journal of biological chemistry. 2008 Oct 10

  View Free Full Text

• Fatty acid 2-hydroxylase, encoded by FA2H, accounts for differentiation-associated increase in 2-OH ceramides during keratinocyte differentiation.

  Ceramides in mammalian stratum corneum comprise a heterogeneous mixture of molecular species that subserve the epidermal permeability barrier, an esse…

  Authors: Yoshikazu Uchida, Hiroko Hama, Nathan L Alderson, Sounthala Douangpanya, Yu Wang, Debra A Crumrine, Peter M Elias, Walter M Holleran

  Source: The Journal of biological chemistry. 2007 May 4

  View Full Text