1 to 10 of 35 literature results

• Oral CD3-specific antibody suppresses autoimmune encephalomyelitis by inducing CD4+ CD25- LAP+ T cells.

  A major goal of immunotherapy for autoimmune diseases and transplantation is induction of regulatory T cells that mediate immunologic tolerance. The m…

  Authors: Hirofumi Ochi, Michal Abraham, Hiroki Ishikawa, Dan Frenkel, Kaiyong Yang, Alexandre S Basso, Henry Wu, Mei-Ling Chen, Roopali Gandhi, Ariel Miller,…

  Source: Nature medicine. 2006 Jun

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• Inhibition of autoimmune diabetes by oral administration of anti-CD3 monoclonal antibody.

  Anti-CD3 monoclonal antibody (mAb) has been shown to induce tolerance and to be an effective treatment for diabetes both in animal models and in human…

  Authors: Hiroki Ishikawa, Hirofumi Ochi, Mei-Ling Chen, Dan Frenkel, Ruth Maron, Howard L Weiner

  Source: Diabetes. 2007 Aug

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• Recovery from experimental allergic encephalomyelitis is TGF-beta dependent and associated with increases in CD4+LAP+ and CD4+CD25+ T cells.

  SJL mice are highly susceptible to proteolipid protein (PLP) 139-151-induced experimental allergic encephalomyelitis (EAE). The disease is characteriz…

  Authors: Xingmin Zhang, Jayagopala Reddy, Hirofumi Ochi, Dan Frenkel, Vijay K Kuchroo, Howard L Weiner

  Source: International immunology. 2006 Apr

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• Intrathecal upregulation of IFN-gamma and MIP-1beta in juvenile muscular atrophy of the distal upper extremity.

  Juvenile muscular atrophy of the distal upper extremity (JMADUE) is associated with airway allergy and hyperIgEaemia, suggesting the involvement of im…

  Authors: Masahito Tanaka, Takaaki Ishizu, Hirofumi Ochi, Yuji Kawano, Yasumasa Ohyagi, Jun-ichi Kira

  Source: Journal of the neurological sciences. 2008 Dec 15

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• Heterogeneity and continuum of multiple sclerosis in Japanese according to magnetic resonance imaging findings.

  There are two distinct subtypes of multiple sclerosis (MS) in Asians: optic-spinal (OSMS) and conventional (CMS). Longitudinally extensive spinal cord…

  Authors: Takeshi Matsuoka, Takuya Matsushita, Manabu Osoegawa, Hirofumi Ochi, Yuji Kawano, Futoshi Mihara, Yasumasa Ohyagi, Jun-ichi Kira

  Source: Journal of the neurological sciences. 2008 Mar 15

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• New immunosuppressive approaches: oral administration of CD3-specific antibody to treat autoimmunity.

  One of the major goals for the immunotherapy of autoimmune diseases is the induction of regulatory T cells that mediate immunologic tolerance. Parente…

  Authors: Hirofumi Ochi, Michal Abraham, Hiroki Ishikawa, Dan Frenkel, Kaiyong Yang, Alexandre Basso, Henry Wu, Mei-Ling Chen, Roopali Gandhi, Ariel Miller,…

  Source: Journal of the neurological sciences. 2008 Nov 15

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• Long-term favorable response to interferon beta-1b is linked to cytokine deviation toward the Th2 and Tc2 sides in Japanese patients with multiple sclerosis.

  To address the immune mechanism of the long-term beneficial effects of interferon beta (IFN-beta), we measured the intracellular cytokine production p…

  Authors: Feng-Jun Mei, Manabu Osoegawa, Hirofumi Ochi, Motozumi Minohara, Shi Nan, Hiroyuki Murai, Takaaki Ishizu, Takayuki Taniwaki, Jun-ichi Kira

  Source: Journal of the neurological sciences. 2006 Jul 15

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• Platelet-activating factor receptor gene polymorphism in Japanese patients with multiple sclerosis.

  We evaluated the association of the platelet-activating factor receptor (PAFR) gene polymorphism (A224D) with the susceptibility and severity of multi…

  Authors: Manabu Osoegawa, Ryuji Miyagishi, Hirofumi Ochi, Itta Nakamura, Masaaki Niino, Seiji Kikuchi, Hiroyuki Murai, Toshiyuki Fukazawa, Motozumi Minohara, Kunio Tashiro,…

  Source: Journal of neuroimmunology. 2005 Apr

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• Th2 shift in juvenile muscular atrophy of distal upper extremity: a combined allergological and flow cytometric analysis.

  Juvenile muscular atrophy of the distal upper extremity (JMADUE) is considered to be a type of flexion myelopathy; however, we recently reported cases…

  Authors: Manabu Osoegawa, Hirofumi Ochi, Feng-Jun Mei, Motozumi Minohara, Hiroyuki Murai, Takayuki Taniwaki, Jun-ichi Kira

  Source: Journal of the neurological sciences. 2005 Jan 15

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• Platelet-activating factor acetylhydrolase gene polymorphism and its activity in Japanese patients with multiple sclerosis.

  We evaluated the association of the plasma platelet-activating factor acetylhydrolase (PAF-AH) gene polymorphism (G(994)-->T) and PAF-AH activity with…

  Authors: Manabu Osoegawa, Masaaki Niino, Hirofumi Ochi, Seiji Kikuchi, Hiroyuki Murai, Toshiyuki Fukazawa, Motozumi Minohara, Kunio Tashiro, Jun-Ichi Kira

  Source: Journal of neuroimmunology. 2004 May

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