1 to 10 of 75 literature results

• Immunology and the elusive AIDS vaccine.

  Developing a human immunodeficiency virus (HIV) vaccine is critical to end the global acquired immunodeficiency syndrome (AIDS) epidemic, but many que…

  Authors: Herbert W Virgin, Bruce D Walker

  Source: Nature. 2010 Mar 11

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• Autophagy genes in immunity.

  In its classical form, autophagy is a pathway by which cytoplasmic constituents, including intracellular pathogens, are sequestered in a double-membra…

  Authors: Herbert W Virgin, Beth Levine

  Source: Nature immunology. 2009 May

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• Redefining chronic viral infection.

  Viruses that cause chronic infection constitute a stable but little-recognized part of our metagenome: our virome. Ongoing immune responses hold these…

  Authors: Herbert W Virgin, E John Wherry, Rafi Ahmed

  Source: Cell. 2009 Jul 10

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• Herpesvirus latency confers symbiotic protection from bacterial infection.

  All humans become infected with multiple herpesviruses during childhood. After clearance of acute infection, herpesviruses enter a dormant state known…

  Authors: Erik S Barton, Douglas W White, Jason S Cathelyn, Kelly A Brett-McClellan, Michael Engle, Michael S Diamond, Virginia L Miller, Herbert W Virgin

  Source: Nature. 2007 May 17

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• A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells.

  Susceptibility to Crohn's disease, a complex inflammatory disease involving the small intestine, is controlled by over 30 loci. One Crohn's disease ri…

  Authors: Ken Cadwell, John Y Liu, Sarah L Brown, Hiroyuki Miyoshi, Joy Loh, Jochen K Lennerz, Chieko Kishi, Wumesh Kc, Javier A Carrero, Steven Hunt,…

  Source: Nature. 2008 Nov 13

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• Disruption of Erk-dependent type I interferon induction breaks the myxoma virus species barrier.

  Myxoma virus, a member of the poxvirus family, causes lethal infection only in rabbits, but the mechanism underlying the strict myxoma virus species b…

  Authors: Fuan Wang, Yiyue Ma, John W Barrett, Xiujuan Gao, Joy Loh, Erik Barton, Herbert W Virgin, Grant McFadden

  Source: Nature immunology. 2004 Dec

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• Murine gammaherpesvirus 68 has evolved gamma interferon and stat1-repressible promoters for the lytic switch gene 50.

  Cytokines regulate viral gene expression with important consequences for viral replication and pathogenesis. Gamma interferon (IFN-gamma) is a key reg…

  Authors: Megan M Goodwin, Susan Canny, Ashley Steed, Herbert W Virgin

  Source: Journal of virology. 2010 Apr

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• Mouse norovirus replication is associated with virus-induced vesicle clusters originating from membranes derived from the secretory pathway.

  Human noroviruses (family Caliciviridae) are the leading cause of nonbacterial gastroenteritis worldwide. Despite the prevalence of these viruses with…

  Authors: Jennifer L Hyde, Stanislav V Sosnovtsev, Kim Y Green, Christiane Wobus, Herbert W Virgin, Jason M Mackenzie

  Source: Journal of virology. 2009 Oct

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• Murine gammaherpesvirus 68 genes both induce and suppress lymphoproliferative disease.

  Gammaherpesvirus infection is associated with an increased incidence of lymphoproliferative disease in immunocompromised hosts. Murine gammaherpesviru…

  Authors: Vera L Tarakanova, Friederike Kreisel, Douglas W White, Herbert W Virgin

  Source: Journal of virology. 2008 Jan

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• Virus subversion of the MHC class I peptide-loading complex.

  Many viral proteins modulate class I expression, yet, in general, their mechanisms of specific class I recognition are poorly understood. The mK3 prot…

  Authors: Lonnie Lybarger, Xiaoli Wang, Michael R Harris, Herbert W Virgin, Ted H Hansen

  Source: Immunity. 2003 Jan

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