1 to 10 of 11 literature results

• TP53 mutation analysis of malignant peripheral nerve sheath tumors.

  Mutations in TP53 underlie the development of malignant peripheral nerve sheath tumors (MPNSTs) in animal models, but there is controversy regarding t…

  Authors: Robert M Verdijk, Michael A den Bakker, Hendrikus J Dubbink, Wim C J Hop, Winand N M Dinjens, Johan M Kros

  Source: Journal of neuropathology and experimental neurology. 2010 Jan

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• The androgen receptor ligand-binding domain stabilizes DNA binding in living cells.

  The androgen receptor (AR) is a member of the steroid receptor family, a group of transcription factors that activate steroid-regulated genes. Live ce…

  Authors: Pascal Farla, Remko Hersmus, Bart Geverts, Pierre O Mari, Alex L Nigg, Hendrikus J Dubbink, Jan Trapman, Adriaan B Houtsmuller

  Source: Journal of structural biology. 2004 Jul

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• Functional screening of FxxLF-like peptide motifs identifies SMARCD1/BAF60a as an androgen receptor cofactor that modulates TMPRSS2 expression.

  Androgen receptor (AR) transcriptional activity is tightly regulated by interacting cofactors and cofactor complexes. The best described cofactor inte…

  Authors: Dennis J van de Wijngaart, Hendrikus J Dubbink, Michel Molier, Carola de Vos, Jan Trapman, Guido Jenster

  Source: Molecular endocrinology (Baltimore, Md.). 2009 Nov

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• Systematic structure-function analysis of androgen receptor Leu701 mutants explains the properties of the prostate cancer mutant L701H.

  One mechanism of prostate tumors for escape from androgen ablation therapies is mutation of the androgen receptor (AR). We investigated the unique pro…

  Authors: Dennis J van de Wijngaart, Michel Molier, Scott J Lusher, Remko Hersmus, Guido Jenster, Jan Trapman, Hendrikus J Dubbink

  Source: The Journal of biological chemistry. 2010 Feb 12

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• Compartmentalization of androgen receptor protein-protein interactions in living cells.

  Steroid receptors regulate gene expression in a ligand-dependent manner by binding specific DNA sequences. Ligand binding also changes the conformatio…

  Authors: Martin E van Royen, Sónia M Cunha, Maartje C Brink, Karin A Mattern, Alex L Nigg, Hendrikus J Dubbink, Pernette J Verschure, Jan Trapman, Adriaan B Houtsmuller

  Source: The Journal of cell biology. 2007 Apr 9

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• Androgen receptor ligand-binding domain interaction and nuclear receptor specificity of FXXLF and LXXLL motifs as determined by L/F swapping.

  The androgen receptor (AR) ligand-binding domain (LBD) binds FXXLF motifs, present in the AR N-terminal domain and AR-specific cofactors, and some LXX…

  Authors: Hendrikus J Dubbink, Remko Hersmus, Ashley C W Pike, Michel Molier, Albert O Brinkmann, Guido Jenster, Jan Trapman

  Source: Molecular endocrinology (Baltimore, Md.). 2006 Aug

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• MGMT promoter methylation is prognostic but not predictive for outcome to adjuvant PCV chemotherapy in anaplastic oligodendroglial tumors: a report from EORTC Brain Tumor Group Study 26951.

  PURPOSE: O6-methylguanine-methyltransferase (MGMT) promoter methylation has been shown to predict survival of patients with glioblastomas if temozolom…

  Authors: Martin J van den Bent, Hendrikus J Dubbink, Marc Sanson, Cathleen R van der Lee-Haarloo, Monika Hegi, Judith W M Jeuken, Ahmed Ibdaih, Alba A Brandes, Martin J B Taphoorn, Marc Frenay,…

  Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2009 Dec 10

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• IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treatment of Cancer Brain Tumor Group.

  PURPOSE: Recent studies have shown the prognostic significance of IDH1 mutations in glioma. It is yet unclear if IDH1 mutations are predictive for out…

  Authors: Martin J van den Bent, Hendrikus J Dubbink, Yannick Marie, Alba A Brandes, Martin J B Taphoorn, Pieter Wesseling, Marc Frenay, Cees C Tijssen, Denis Lacombe, Ahmed Idbaih,…

  Source: Clinical cancer research : an official journal of the American Association for Cancer Research. 2010 Mar 1

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• Novel FXXFF and FXXMF motifs in androgen receptor cofactors mediate high affinity and specific interactions with the ligand-binding domain.

  Upon hormone binding, a hydrophobic coactivator binding groove is induced in the androgen receptor (AR) ligand-binding domain (LBD). This groove serve…

  Authors: Dennis J van de Wijngaart, Martin E van Royen, Remko Hersmus, Ashley C W Pike, Adriaan B Houtsmuller, Guido Jenster, Jan Trapman, Hendrikus J Dubbink

  Source: The Journal of biological chemistry. 2006 Jul 14

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• Distinct recognition modes of FXXLF and LXXLL motifs by the androgen receptor.

  Among nuclear receptors, the androgen receptor (AR) is unique in that its ligand-binding domain (LBD) interacts with the FXXLF motif in the N-terminal…

  Authors: Hendrikus J Dubbink, Remko Hersmus, Chandra S Verma, Hetty A G M van der Korput, Cor A Berrevoets, Judith van Tol, Angelique C J Ziel-van der Made, Albert O Brinkmann, Ashley C W Pike, Jan Trapman

  Source: Molecular endocrinology (Baltimore, Md.). 2004 Sep

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