1 to 6 of 6 literature results

• Loss of small heterodimer partner expression in the liver protects against dyslipidemia.

  Multiple studies suggest increased conversion of cholesterol to bile acids by cholesterol 7alpha-hydroxylase (CYP7A1) protects against dyslipidemia an…

  Authors: Helen B Hartman, Kehdih Lai, Mark J Evans

  Source: Journal of lipid research. 2009 Feb

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• Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR-/- and apoE-/- mice.

  The role of farnesoid X receptor (FXR) in the development of atherosclerosis has been unclear. Here, LDL receptor (LDLR(-/-)) or apolipoprotein E (apo…

  Authors: Helen B Hartman, Stephen J Gardell, Chris J Petucci, Shuguang Wang, Julie A Krueger, Mark J Evans

  Source: Journal of lipid research. 2009 Jun

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• The histone-binding code of nuclear receptor co-repressors matches the substrate specificity of histone deacetylase 3.

  Ligands for nuclear receptors facilitate the exchange of co-repressors for coactivators, leading to chromatin modifications that favour the activation…

  Authors: Helen B Hartman, Jiujiu Yu, Theresa Alenghat, Takahiro Ishizuka, Mitchell A Lazar

  Source: EMBO reports. 2005 May

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• The nuclear hormone receptor farnesoid X receptor (FXR) is activated by androsterone.

  Farnesoid X receptor (FXR) uses bile acids as endogenous ligands. Here, we demonstrate that androsterone, a metabolic product of testosterone, is also…

  Authors: Shuguang Wang, KehDih Lai, Franklin J Moy, Anitha Bhat, Helen B Hartman, Mark J Evans

  Source: Endocrinology. 2006 Sep

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• LXR ligand lowers LDL cholesterol in primates, is lipid neutral in hamster, and reduces atherosclerosis in mouse.

  Liver X receptors (LXRs) are ligand-activated transcription factors that coordinate regulation of gene expression involved in several cellular functio…

  Authors: Elaine M Quinet, Michael D Basso, Anita R Halpern, David W Yates, Robert J Steffan, Valerie Clerin, Christine Resmini, James C Keith, Thomas J Berrodin, Irene Feingold,…

  Source: Journal of lipid research. 2009 Dec

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• Mechanisms regulating adipocyte expression of resistin.

  Resistin, also known as Adipocyte Secreted Factor (ADSF) and Found in Inflammatory Zone 3 (FIZZ3), is a mouse protein with potential roles in insulin …

  Authors: Helen B Hartman, Xiao Hu, Keala X Tyler, Chiraj K Dalal, Mitchell A Lazar

  Source: The Journal of biological chemistry. 2002 May 31

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