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• Two isoforms of otubain 1 regulate T cell anergy via GRAIL.

  The active ubiquitin E3 ligase GRAIL is crucial in the induction of CD4 T cell anergy. Here we show that GRAIL is associated with and regulated by two…

  Authors: Luis Soares, Christine Seroogy, Heidi Skrenta, Niroshana Anandasabapathy, Patricia Lovelace, Chan D Chung, Edgar Engleman, C Garrison Fathman

  Source: Nature immunology. 2004 Jan

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• GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells.

  T cell anergy may serve to limit autoreactive T cell responses. We examined early changes in gene expression after antigen-TCR signaling in the presen…

  Authors: Niroshana Anandasabapathy, Gregory S Ford, Debra Bloom, Claire Holness, Violette Paragas, Christine Seroogy, Heidi Skrenta, Marie Hollenhorst, C Garrison Fathman, Luis Soares

  Source: Immunity. 2003 Apr

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