1 to 10 of 82 literature results

• Ascending and transverse aortic arch repair: the impact of retrograde cerebral perfusion.

  BACKGROUND: The benefit of retrograde cerebral perfusion (RCP) with profound hypothermic circulatory arrest has been subject to much debate. We examin…

  Authors: Anthony L Estrera, Charles C Miller, Taek-Yeon Lee, Pallav Shah, Hazim J Safi

  Source: Circulation. 2008 Sep 30

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• Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections.

  The major function of vascular smooth muscle cells (SMCs) is contraction to regulate blood pressure and flow. SMC contractile force requires cyclic in…

  Authors: Dong-Chuan Guo, Hariyadarshi Pannu, Van Tran-Fadulu, Christina L Papke, Robert K Yu, Nili Avidan, Scott Bourgeois, Anthony L Estrera, Hazim J Safi, Elizabeth Sparks,…

  Source: Nature genetics. 2007 Dec

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• Mutations in smooth muscle alpha-actin (ACTA2) cause coronary artery disease, stroke, and Moyamoya disease, along with thoracic aortic disease.

  The vascular smooth muscle cell (SMC)-specific isoform of alpha-actin (ACTA2) is a major component of the contractile apparatus in SMCs located throug…

  Authors: Dong-Chuan Guo, Christina L Papke, Van Tran-Fadulu, Ellen S Regalado, Nili Avidan, Ralph Jay Johnson, Dong H Kim, Hariyadarshi Pannu, Marcia C Willing, Elizabeth Sparks,…

  Source: American journal of human genetics. 2009 May

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• Ascending and transverse aortic arch repair: the impact of glomerular filtration rate on mortality.

  BACKGROUND: Recent studies have described the importance of renal glomerular filtration rate (GFR) as a determinant of perioperative mortality in pati…

  Authors: Anthony L Estrera, Charles C Miller, Jaswanth Madisetty, Sebastian Bourgeois, Ali Azizzadeh, Martin A Villa, Hazim J Safi

  Source: Annals of surgery. 2008 Mar

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• Outcomes of medical management of acute type B aortic dissection.

  BACKGROUND: Currently, the optimal treatment of acute type B aortic dissection remains controversial. The purpose of this study was to report early cl…

  Authors: Anthony L Estrera, Charles C Miller, Hazim J Safi, Jennifer S Goodrick, Arash Keyhani, Eyal E Porat, Paul E Achouh, Riad Meada, Ali Azizzadeh, Jayesh Dhareshwar,…

  Source: Circulation. 2006 Jul 4

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• MYH11 mutations result in a distinct vascular pathology driven by insulin-like growth factor 1 and angiotensin II.

  Non-syndromic thoracic aortic aneurysms and dissections (TAADs) are inherited in an autosomal dominant manner in approximately 20% of cases. Familial …

  Authors: Hariyadarshi Pannu, Van Tran-Fadulu, Christina L Papke, Steve Scherer, Yaozhong Liu, Caroline Presley, Dongchuan Guo, Anthony L Estrera, Hazim J Safi, Allan R Brasier,…

  Source: Human molecular genetics. 2007 Oct 15

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• Mutations in transforming growth factor-beta receptor type II cause familial thoracic aortic aneurysms and dissections.

  BACKGROUND: A genetic predisposition for progressive enlargement of thoracic aortic aneurysms leading to type A dissection (TAAD) is inherited in an a…

  Authors: Hariyadarshi Pannu, Van Tran Fadulu, Jessica Chang, Andrea Lafont, Sumera N Hasham, Elizabeth Sparks, Philip F Giampietro, Christina Zaleski, Anthony L Estrera, Hazim J Safi,…

  Source: Circulation. 2005 Jul 26

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• Electronegative LDL circulating in smokers impairs endothelial progenitor cell differentiation by inhibiting Akt phosphorylation via LOX-1.

  Endothelial progenitor cells (EPCs), important for endothelial regeneration and vasculogenesis, are reduced by cigarette smoking. To elucidate the mec…

  Authors: Daming Tang, Jonathan Lu, Jeffrey P Walterscheid, Hsin-Hung Chen, David A Engler, Tatsuya Sawamura, Po-Yuan Chang, Hazim J Safi, Chao-Yuh Yang, Chu-Huang Chen

  Source: Journal of lipid research. 2008 Jan

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• Staged repair of extensive aortic aneurysms: long-term experience with the elephant trunk technique.

  OBJECTIVE: This paper reports our experience of a large series of elephant trunk patients accumulated over 12 years. SUMMARY BACKGROUND DATA: Extensiv…

  Authors: Hazim J Safi, Charles C Miller, Anthony L Estrera, Tam T T Huynh, Eyal E Porat, Bradley S Allen, Roy Sheinbaum

  Source: Annals of surgery. 2004 Oct

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• Progress and future challenges in thoracoabdominal aortic aneurysm management.

  BACKGROUND: Postoperative paraplegia and paraparesis have been the scourge of thoracoabdominal aortic repair since the inception of the procedure. MET…

  Authors: Hazim J Safi, Anthony L Estrera, Ali Azizzadeh, Sheila Coogan, Charles C Miller

  Source: World journal of surgery. 2008 Mar

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