1 to 10 of 14 literature results

• Differentiation stage determines potential of hematopoietic cells for reprogramming into induced pluripotent stem cells.

  The reprogramming of somatic cells into induced pluripotent stem (iPS) cells upon overexpression of the transcription factors Oct4, Sox2, Klf4 and cMy…

  Authors: Sarah Eminli, Adlen Foudi, Matthias Stadtfeld, Nimet Maherali, Tim Ahfeldt, Gustavo Mostoslavsky, Hanno Hock, Konrad Hochedlinger

  Source: Nature genetics. 2009 Sep

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• Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells.

  Hematopoietic stem cells (HSCs) are thought to divide infrequently based on their resistance to cytotoxic injury targeted at rapidly cycling cells and…

  Authors: Adlen Foudi, Konrad Hochedlinger, Denille Van Buren, Jeffrey W Schindler, Rudolf Jaenisch, Vincent Carey, Hanno Hock

  Source: Nature biotechnology. 2009 Jan

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• Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells.

  Haematopoietic stem cells (HSCs) sustain blood production throughout life. HSCs are capable of extensive proliferative expansion, as a single HSC may …

  Authors: Hanno Hock, Melanie J Hamblen, Heather M Rooke, Jeffrey W Schindler, Shireen Saleque, Yuko Fujiwara, Stuart H Orkin

  Source: Nature. 2004 Oct 21

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• Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene.

  The production of blood cells is sustained throughout the lifetime of an individual by haematopoietic stem cells (HSCs). Specification of HSCs from me…

  Authors: Hanna K A Mikkola, Jenny Klintman, Haidi Yang, Hanno Hock, Thorsten M Schlaeger, Yuko Fujiwara, Stuart H Orkin

  Source: Nature. 2003 Jan 30

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• ETV6-NTRK3 fusion oncogene initiates breast cancer from committed mammary progenitors via activation of AP1 complex.

  To better understand the cellular origin of breast cancer, we developed a mouse model that recapitulates expression of the ETV6-NTRK3 (EN) fusion onco…

  Authors: Zhe Li, Cristina E Tognon, Frank J Godinho, Laura Yasaitis, Hanno Hock, Jason I Herschkowitz, Chris L Lannon, Eunah Cho, Seong-Jin Kim, Roderick T Bronson,…

  Source: Cancer cell. 2007 Dec

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• Stem cells: the road not taken.

  Authors: Hanno Hock, Stuart H Orkin

  Source: Nature. 2005 Jun 2

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• Neutrophils in a mouse model of autoantibody-mediated arthritis: critical producers of Fc receptor gamma, the receptor for C5a, and lymphocyte function-associated antigen 1.

  OBJECTIVE: Neutrophils represent a prominent component of inflammatory joint effusions and are required for synovial inflammation in mouse models, but…

  Authors: Paul A Monach, Peter A Nigrovic, Mei Chen, Hanno Hock, David M Lee, Christophe Benoist, Diane Mathis

  Source: Arthritis and rheumatism. 2010 Mar

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• Zinc-finger transcription factor Gfi-1: versatile regulator of lymphocytes, neutrophils and hematopoietic stem cells.

  PURPOSE OF REVIEW: Gfi-1, originally identified as a transcriptional repressor in lymphoid cells, is now recognized to have essential, independent fun…

  Authors: Hanno Hock, Stuart H Orkin

  Source: Current opinion in hematology. 2006 Jan

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• Tel/Etv6 is an essential and selective regulator of adult hematopoietic stem cell survival.

  Hematopoietic stem cells (HSCs) sustain blood formation throughout life. Pathways regulating maintenance of adult HSCs are largely unknown. Here we re…

  Authors: Hanno Hock, Eliza Meade, Sarah Medeiros, Jeffrey W Schindler, Peter J M Valk, Yuko Fujiwara, Stuart H Orkin

  Source: Genes & development. 2004 Oct 1

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• Intrinsic requirement for zinc finger transcription factor Gfi-1 in neutrophil differentiation.

  We report essential roles of zinc finger transcription factor Gfi-1 in myeloid development. Gene-targeted Gfi-1(-/-) mice lack normal neutrophils and …

  Authors: Hanno Hock, Melanie J Hamblen, Heather M Rooke, David Traver, Roderick T Bronson, Scott Cameron, Stuart H Orkin

  Source: Immunity. 2003 Jan

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