1 to 9 of 9 literature results

• Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism.

  Dysregulation of lipid metabolism in individual tissues leads to systemic disruption of insulin action and glucose metabolism. Utilizing quantitative …

  Authors: Haiming Cao, Kristin Gerhold, Jared R Mayers, Michelle M Wiest, Steven M Watkins, Gökhan S Hotamisligil

  Source: Cell. 2008 Sep 19

  View Free Full Text

• Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis.

  As chronic inflammation is a hallmark of obesity, pathways that integrate nutrient- and pathogen sensing pathways are of great interest in understandi…

  Authors: Takahisa Nakamura, Masato Furuhashi, Ping Li, Haiming Cao, Gurol Tuncman, Nahum Sonenberg, Cem Z Gorgun, Gökhan S Hotamisligil

  Source: Cell. 2010 Feb 5

  View Full Text

• Regulation of metabolic responses by adipocyte/macrophage Fatty Acid-binding proteins in leptin-deficient mice.

  Fatty acid-binding proteins (FABPs) are cytosolic fatty acid chaperones that play a critical role in systemic regulation of lipid and glucose metaboli…

  Authors: Haiming Cao, Kazuhisa Maeda, Cem Z Gorgun, Hyo-Jeong Kim, So-Young Park, Gerald I Shulman, Jason K Kim, Gökhan S Hotamisligil

  Source: Diabetes. 2006 Jul

  View Full Text

• Oxidative stress activates both Src-kinases and their negative regulator Csk and induces phosphorylation of two targeting proteins for Csk: caveolin-1 and paxillin.

  Csk negatively regulates Src family kinases (SFKs). In lymphocytes, Csk is constitutively active, and is transiently inactivated in response to extrac…

  Authors: Haiming Cao, Amy R Sanguinetti, Cynthia Corley Mastick

  Source: Experimental cell research. 2004 Mar 10

  View Full Text

• Adipocyte/macrophage fatty acid binding proteins in metabolic syndrome.

  The link between inflammation and the development of insulin resistance, type 2 diabetes, and atherosclerosis has been uncovered in the past decade. A…

  Authors: Ebru Erbay, Haiming Cao, Gökhan S Hotamisligil

  Source: Current atherosclerosis reports. 2007 Sep

  View Full Text

• Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice.

  Adipose tissue inflammation is a characteristic of obesity. However, the mechanisms that regulate this inflammatory response and link adipose inflamma…

  Authors: Masato Furuhashi, Raquel Fucho, Cem Z Görgün, Gürol Tuncman, Haiming Cao, Gökhan S Hotamisligil

  Source: The Journal of clinical investigation. 2008 Jul

  View Free Full Text

• Fyn is required for oxidative- and hyperosmotic-stress-induced tyrosine phosphorylation of caveolin-1.

  Caveolin-1 is phosphorylated on Tyr(14) in response to both oxidative and hyperosmotic stress. In the present paper, we show that this phosphorylation…

  Authors: Amy R Sanguinetti, Haiming Cao, Cynthia Corley Mastick

  Source: The Biochemical journal. 2003 Nov 15

  View Free Full Text

• Adipocyte/macrophage fatty acid binding proteins control integrated metabolic responses in obesity and diabetes.

  Fatty acid binding proteins (FABPs) are cytosolic fatty acid chaperones whose biological role and mechanisms of action are not well understood. Here, …

  Authors: Kazuhisa Maeda, Haiming Cao, Keita Kono, Cem Z Gorgun, Masato Furuhashi, Kadir T Uysal, Qiong Cao, Genichi Atsumi, Harry Malone, Bala Krishnan,…

  Source: Cell metabolism. 2005 Feb

  View Full Text

• A phosphotyrosine-dependent protein interaction screen reveals a role for phosphorylation of caveolin-1 on tyrosine 14: recruitment of C-terminal Src kinase.

  Caveolin-1 is a substrate for nonreceptor tyrosine kinases including Src, Fyn, and Abl. To investigate the function of caveolin-1 phosphorylation, we …

  Authors: Haiming Cao, William E Courchesne, Cynthia Corley Mastick

  Source: The Journal of biological chemistry. 2002 Mar 15

  View Full Text