1 to 10 of 11 literature results

• The somatostatin analogue octreotide confers sensitivity to rapamycin treatment on pituitary tumor cells.

  Rapamycin and its analogues have significant antiproliferative action against a variety of tumors. However, sensitivity to rapamycin is reduced by Akt…

  Authors: Vesna Cerovac, Jose Monteserin-Garcia, Hadara Rubinfeld, Michael Buchfelder, Marco Losa, Tullio Florio, Marcelo Paez-Pereda, Günter K Stalla, Marily Theodoropoulou

  Source: Cancer research. 2010 Jan 15

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• Mammalian target of rapamycin inhibitors rapamycin and RAD001 (everolimus) induce anti-proliferative effects in GH-secreting pituitary tumor cells in vitro.

  The effect of mammalian target of rapamycin (mTOR) inhibitors on pituitary tumors is unknown. Akt overexpression was demonstrated in pituitary adenoma…

  Authors: Alexander Gorshtein, Hadara Rubinfeld, Efrat Kendler, Marily Theodoropoulou, Vesna Cerovac, Günter K Stalla, Zvi R Cohen, Moshe Hadani, Ilan Shimon

  Source: Endocrine-related cancer. 2009 Sep

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• The rapamycin-derivative RAD001 (everolimus) inhibits cell viability and interacts with the Akt-mTOR-p70S6K pathway in human medullary thyroid carcinoma cells.

  Over-expression of the proto-oncogene Akt/PKB has been demonstrated in some neuroendocrine tumor models. Akt may activate downstream proteins such as …

  Authors: Simona Grozinsky-Glasberg, Hadara Rubinfeld, Yardena Nordenberg, Alexander Gorshtein, Michal Praiss, Efrat Kendler, Rafael Feinmesser, Ashley B Grossman, Ilan Shimon

  Source: Molecular and cellular endocrinology. 2010 Feb 5

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• Role of protein kinase C delta in reactivation of Kaposi's sarcoma-associated herpesvirus.

  TPA (12-O-tetradecanoylphorbol-13-acetate), a well-known activator of protein kinase C (PKC), can experimentally induce reactivation of Kaposi's sarco…

  Authors: Einat Deutsch, Adina Cohen, Gila Kazimirsky, Sara Dovrat, Hadara Rubinfeld, Chaya Brodie, Ronit Sarid

  Source: Journal of virology. 2004 Sep

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• The ERK cascade: a prototype of MAPK signaling.

  Sequential activation of protein kinases within the mitogen-activated protein kinase (MAPK) cascades is a common mechanism of signal transduction in m…

  Authors: Hadara Rubinfeld, Rony Seger

  Source: Molecular biotechnology. 2005 Oct

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• PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters.

  RasGRP is a family of guanine nucleotide exchange factors that activate small GTPases and contain a C1 domain similar to the one present in protein ki…

  Authors: Chaya Brodie, Rivka Steinhart, Gila Kazimirsky, Hadara Rubinfeld, Tehila Hyman, Jolene N Ayres, Gang Min Hur, Attila Toth, Dazhi Yang, Susan H Garfield,…

  Source: Molecular pharmacology. 2004 Jul

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• Nitric oxide stimulates growth hormone secretion from human fetal pituitaries and cultured pituitary adenomas.

  Nitric oxide (NO), a highly reactive free radical, has been identified as a neurotransmitter in the central and peripheral nervous system. NO synthase…

  Authors: Tami Rubinek, Hadara Rubinfeld, Moshe Hadani, Gad Barkai, Ilan Shimon

  Source: Endocrine. 2005 Nov

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• Cortistatin - a new neuroendocrine hormone?

  Cortistatin (CST) is a recently described neuropeptide. Although the expression of CST was initially reported to be restricted to the rat cerebral cor…

  Authors: Hadara Rubinfeld, Ilan Shimon

  Source: Pediatric endocrinology reviews : PER. 2006 Dec-2007 Jan

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• Melanin-concentrating hormone stimulates human growth hormone secretion: a novel effect of MCH on the hypothalamic-pituitary axis.

  Melanin-concentrating hormone (MCH), a 19-amino acid orexigenic (appetite-stimulating) hypothalamic peptide, is an important regulator of energy homeo…

  Authors: Gabriella Segal-Lieberman, Hadara Rubinfeld, Moran Glick, Noga Kronfeld-Schor, Ilan Shimon

  Source: American journal of physiology. Endocrinology and metabolism. 2006 May

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• Cortistatin inhibits growth hormone release from human fetal and adenoma pituitary cells and prolactin secretion from cultured prolactinomas.

  CONTEXT: Cortistatin (CST) is a neuropeptide that shares high homology with somatostatin and binds with high affinity to all somatostatin receptor (SS…

  Authors: Hadara Rubinfeld, Moshe Hadani, Gad Barkai, John E Taylor, Michael D Culler, Ilan Shimon

  Source: The Journal of clinical endocrinology and metabolism. 2006 Jun

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