1 to 10 of 24 literature results

• Thymic stromal lymphopoietin as a key initiator of allergic airway inflammation in mice.

  The cytokine thymic stromal lymphopoietin (TSLP) has been linked to human allergic inflammatory diseases. We show here that TSLP expression was increa…

  Authors: Baohua Zhou, Michael R Comeau, Thibaut De Smedt, H Denny Liggitt, Martin E Dahl, David B Lewis, Dora Gyarmati, Theingi Aye, Daniel J Campbell, Steven F Ziegler

  Source: Nature immunology. 2005 Oct

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• Growth factor receptors as regulators of hematopoiesis.

  Nearly 15 years have elapsed since the US Food and Drug Administration last approved a major new hematopoietic cytokine. Promiscuous binding to multip…

  Authors: Michael A Weinreich, Ingrid Lintmaer, Linlin Wang, H Denny Liggitt, Michael A Harkey, C Anthony Blau

  Source: Blood. 2006 Dec 1

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• Staphylococcus aureus elicits marked alterations in the airway proteome during early pneumonia.

  Pneumonia caused by Staphylococcus aureus is a growing concern in the health care community. We hypothesized that characterization of the early innate…

  Authors: Christy L Ventura, Roger Higdon, Laura Hohmann, Daniel Martin, Eugene Kolker, H Denny Liggitt, Shawn J Skerrett, Craig E Rubens

  Source: Infection and immunity. 2008 Dec

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• The mSin3A chromatin-modifying complex is essential for embryogenesis and T-cell development.

  The corepressor mSin3A is the core component of a chromatin-modifying complex that is recruited by multiple gene-specific transcriptional repressors. …

  Authors: Shaun M Cowley, Brian M Iritani, Susan M Mendrysa, Tina Xu, Pei Feng Cheng, Jason Yada, H Denny Liggitt, Robert N Eisenman

  Source: Molecular and cellular biology. 2005 Aug

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• Inhalation of Burkholderia thailandensis results in lethal necrotizing pneumonia in mice: a surrogate model for pneumonic melioidosis.

  Burkholderia thailandensis is closely related to B. pseudomallei, the causative agent of melioidosis, a lethal tropical disease. Burkholderia thailand…

  Authors: T Eoin West, Charles W Frevert, H Denny Liggitt, Shawn J Skerrett

  Source: Transactions of the Royal Society of Tropical Medicine and Hygiene. 2008 Dec

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• New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 2): Identification of nephrotoxic metabolites.

  BACKGROUND: Methoxyflurane nephrotoxicity results from its metabolism, which occurs by both dechlorination (to methoxydifluoroacetic acid [MDFA]) and …

  Authors: Evan D Kharasch, Jesara L Schroeder, H Denny Liggitt, Dustin Ensign, Dale Whittington

  Source: Anesthesiology. 2006 Oct

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• Influence of sevoflurane on the metabolism and renal effects of compound A in rats.

  BACKGROUND: The sevoflurane degradation product compound A is nephrotoxic in rats. In contrast, patient exposure to compound A during sevoflurane anes…

  Authors: Evan D Kharasch, Jesara L Schroeder, Pam Sheffels, H Denny Liggitt

  Source: Anesthesiology. 2005 Dec

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• Systemic inflammatory response syndrome in nonhuman primates culminating in multiple organ failure, acute lung injury, and disseminated intravascular coagulation.

  The systemic inflammatory response syndrome (SIRS) is a clinicopathological manifestation of overexuberant acute-phase inflammation caused by infectio…

  Authors: Renee R Hukkanen, H Denny Liggitt, Robert D Murnane, Charles W Frevert

  Source: Toxicologic pathology. 2009

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• New insights into the mechanism of methoxyflurane nephrotoxicity and implications for anesthetic development (part 1): Identification of the nephrotoxic metabolic pathway.

  BACKGROUND: Methoxyflurane nephrotoxicity results from biotransformation; inorganic fluoride is a toxic metabolite. Concern exists about potential ren…

  Authors: Evan D Kharasch, Jesara L Schroeder, H Denny Liggitt, Sang B Park, Dale Whittington, Pamela Sheffels

  Source: Anesthesiology. 2006 Oct

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• An essential role for non-bone marrow-derived cells in control of Pseudomonas aeruginosa pneumonia.

  MyD88 is an adapter protein required for the induction of proinflammatory cytokines by most Toll-like receptors (TLR), and Pseudomonas aeruginosa expr…

  Authors: Adeline M Hajjar, Heidi Harowicz, H Denny Liggitt, Pamela J Fink, Christopher B Wilson, Shawn J Skerrett

  Source: American journal of respiratory cell and molecular biology. 2005 Nov

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