1 to 10 of 13 literature results

• Opa1-mediated cristae opening is Bax/Bak and BH3 dependent, required for apoptosis, and independent of Bak oligomerization.

  Controversy surrounds the role and mechanism of mitochondrial cristae remodeling in apoptosis. Here we show that the proapoptotic BH3-only proteins Bi…

  Authors: Ryuji Yamaguchi, Lydia Lartigue, Guy Perkins, Ray T Scott, Amruta Dixit, Yulia Kushnareva, Tomomi Kuwana, Mark H Ellisman, Donald D Newmeyer

  Source: Molecular cell. 2008 Aug 22

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• New insights into mitochondrial structure during cell death.

  Mitochondria play a pivotal role in the cascade of events associated with cell death pathways that are involved with several forms of neurodegeneratio…

  Authors: Guy Perkins, Ella Bossy-Wetzel, Mark H Ellisman

  Source: Experimental neurology. 2009 Aug

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• Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane.

  Bcl-2 family proteins regulate the release of proteins like cytochrome c from mitochondria during apoptosis. We used cell-free systems and ultimately …

  Authors: Tomomi Kuwana, Mason R Mackey, Guy Perkins, Mark H Ellisman, Martin Latterich, Roger Schneiter, Douglas R Green, Donald D Newmeyer

  Source: Cell. 2002 Nov 1

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• Transform-based backprojection for volume reconstruction of large format electron microscope tilt series.

  Alignment of the individual images of a tilt series is a critical step in obtaining high-quality electron microscope reconstructions. We report on gen…

  Authors: Albert Lawrence, James C Bouwer, Guy Perkins, Mark H Ellisman

  Source: Journal of structural biology. 2006 May

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• Covalently linked Au nanoparticles to a viral vector: potential for combined photothermal and gene cancer therapy.

  Hyperthermia can be produced by near-infrared laser irradiation of gold nanoparticles present in tumors and thus induce tumor cell killing via a bysta…

  Authors: Maaike Everts, Vaibhav Saini, Jennifer L Leddon, Robbert J Kok, Mariam Stoff-Khalili, Meredith A Preuss, C Leigh Millican, Guy Perkins, Joshua M Brown, Hitesh Bagaria,…

  Source: Nano letters. 2006 Apr

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• Dynamics of mitochondrial structure during apoptosis and the enigma of Opa1.

  The large scale remodeling of mitochondria during apoptosis is a necessary step for the complete release of cytochrome c" has been a tenet since 2002.…

  Authors: Ryuji Yamaguchi, Guy Perkins

  Source: Biochimica et biophysica acta. 2009 Aug

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• Differential neuroprotection by cyclosporin A and FK506 following ischemia corresponds with differing abilities to inhibit calcineurin and the mitochondrial permeability transition.

  Transient global or forebrain ischemia leads to severe brain damage following delayed neuronal cell death. We previously reported that cyclosporin A (…

  Authors: Hiroyuki Uchino, Reiko Minamikawa-Tachino, Tibor Kristián, Guy Perkins, Michiko Narazaki, Bo K Siesjö, Futoshi Shibasaki

  Source: Neurobiology of disease. 2002 Aug

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• Clearing the Brain's Cobwebs: The Role of Autophagy in Neuroprotection.

  Protein aggregates or inclusion bodies are common hallmarks of age-related neurodegenerative disorders. Why these aggregates form remains unclear. Equ…

  Authors: Blaise Bossy, Guy Perkins, Ella Bossy-Wetzel

  Source: Current neuropharmacology. 2008 Jun

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• A thermodynamic model describing the nature of the crista junction: a structural motif in the mitochondrion.

  The use of electron tomography has allowed the three-dimensional membrane topography of the mitochondrion to be better understood. The most striking f…

  Authors: Christian Renken, Gino Siragusa, Guy Perkins, Lance Washington, Jim Nulton, Peter Salamon, Terrence G Frey

  Source: Journal of structural biology. 2002 Apr-May

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• Mitochondrial fragmentation in neurodegeneration.

  Mitochondria are remarkably dynamic organelles that migrate, divide and fuse. Cycles of mitochondrial fission and fusion ensure metabolite and mitocho…

  Authors: Andrew B Knott, Guy Perkins, Robert Schwarzenbacher, Ella Bossy-Wetzel

  Source: Nature reviews. Neuroscience. 2008 Jul

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