1 to 10 of 39 literature results

• Systematic pathway analysis using high-resolution fitness profiling of combinatorial gene deletions.

  Systematic genetic interaction studies have illuminated many cellular processes. Here we quantitatively examine genetic interactions among 26 Saccharo…

  Authors: Robert P St Onge, Ramamurthy Mani, Julia Oh, Michael Proctor, Eula Fung, Ronald W Davis, Corey Nislow, Frederick P Roth, Guri Giaever

  Source: Nature genetics. 2007 Feb

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• Yeast chemical genomics and drug discovery: an update.

  The Saccharomyces cerevisiae sequencing project (the first eukaryotic genome decoded) was completed in 1995 and, subsequently, the first version of th…

  Authors: Shawn Hoon, Robert P St Onge, Guri Giaever, Corey Nislow

  Source: Trends in pharmacological sciences. 2008 Oct

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• A chemical genomics approach to understanding drug action.

  The complete collection of yeast deletion strains represents a unique, living biological computer for understanding gene function. The molecular 'barc…

  Authors: Guri Giaever

  Source: Trends in pharmacological sciences. 2003 Sep

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• A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds.

  We present a yeast chemical-genomics approach designed to identify genes that when mutated confer drug resistance, thereby providing insight about the…

  Authors: Cheuk Hei Ho, Leslie Magtanong, Sarah L Barker, David Gresham, Shinichi Nishimura, Paramasivam Natarajan, Judice L Y Koh, Justin Porter, Christopher A Gray, Raymond J Andersen,…

  Source: Nature biotechnology. 2009 Apr

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• Knocking sense into regulatory pathways.

  Authors: Guri Giaever, Corey Nislow

  Source: Nature biotechnology. 2009 Feb

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• Quantitative phenotyping via deep barcode sequencing.

  Next-generation DNA sequencing technologies have revolutionized diverse genomics applications, including de novo genome sequencing, SNP detection, chr…

  Authors: Andrew M Smith, Lawrence E Heisler, Joseph Mellor, Fiona Kaper, Michael J Thompson, Mark Chee, Frederick P Roth, Guri Giaever, Corey Nislow

  Source: Genome research. 2009 Oct

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• Precise gene-dose alleles for chemical genetics.

  Modulating gene dose is an effective way to alter protein levels and modify phenotypes to understand gene function. In addition, combining gene-dose a…

  Authors: Zhun Yan, Nicolas M Berbenetz, Guri Giaever, Corey Nislow

  Source: Genetics. 2009 Jun

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• Experimental approaches to identify genetic networks.

  Systems biology offers the promise of a fully integrated view of cellular physiology. To realize this potential requires the analysis of diverse genom…

  Authors: Michael Costanzo, Guri Giaever, Corey Nislow, Brenda Andrews

  Source: Current opinion in biotechnology. 2006 Oct

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• The extensive and condition-dependent nature of epistasis among whole-genome duplicates in yeast.

  Since complete redundancy between extant duplicates (paralogs) is evolutionarily unfavorable, some degree of functional congruency is eventually lost.…

  Authors: Gabriel Musso, Michael Costanzo, Manqin Huangfu, Andrew M Smith, Jadine Paw, Bryan-Joseph San Luis, Charles Boone, Guri Giaever, Corey Nislow, Andrew Emili,…

  Source: Genome research. 2008 Jul

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• Systematic screen for human disease genes in yeast.

  High similarity between yeast and human mitochondria allows functional genomic study of Saccharomyces cerevisiae to be used to identify human genes in…

  Authors: Lars M Steinmetz, Curt Scharfe, Adam M Deutschbauer, Dejana Mokranjac, Zelek S Herman, Ted Jones, Angela M Chu, Guri Giaever, Holger Prokisch, Peter J Oefner,…

  Source: Nature genetics. 2002 Aug

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