1 to 10 of 58 literature results

• p53 and MDM2: antagonists or partners in crime?

  Therapeutics that disrupt the p53-MDM2 interaction show promise for cancer treatment but surprisingly have different biological outcomes. A study by E…

  Authors: Christine M Eischen, Guillermina Lozano

  Source: Cancer cell. 2009 Mar 3

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• The oncogenic roles of p53 mutants in mouse models.

  Tumors associated with p53 usually contain missense mutations in the p53 tumor suppressor gene rather than deletions of p53, suggesting a growth advan…

  Authors: Guillermina Lozano

  Source: Current opinion in genetics & development. 2007 Feb

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• Gankyrin: an intriguing name for a novel regulator of p53 and RB.

  The RB and p53 tumor suppressors lie at the heart of cancer biology, and inactivation of both pathways is seemingly essential for tumor development. P…

  Authors: Guillermina Lozano, Gerard P Zambetti

  Source: Cancer cell. 2005 Jul

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• p21 stability: linking chaperones to a cell cycle checkpoint.

  Progression through the cell cycle is regulated by numerous proteins, one of which is the cyclin-dependent kinase inhibitor, p21. A new study identifi…

  Authors: Geng Liu, Guillermina Lozano

  Source: Cancer cell. 2005 Feb

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• The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss.

  The p53 tumor suppressor is often disrupted in human cancers by the acquisition of missense mutations. We generated mice with a missense mutation at c…

  Authors: Tamara Terzian, Young-Ah Suh, Tomoo Iwakuma, Sean M Post, Manja Neumann, Gene A Lang, Carolyn S Van Pelt, Guillermina Lozano

  Source: Genes & development. 2008 May 15

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• E2F3 is a mediator of DNA damage-induced apoptosis.

  The E2F transcription factors have emerged as critical apoptotic effectors. Herein we report that the E2F family member E2F3a can be induced by DNA da…

  Authors: Luis A Martinez, Elzbieta Goluszko, Hui-Zi Chen, Gustavo Leone, Sean Post, Guillermina Lozano, Zhenping Chen, Anne Chauchereau

  Source: Molecular and cellular biology. 2010 Jan

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• Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice.

  The p53 protein integrates multiple upstream signals and functions as a tumor suppressor by activating distinct downstream genes. At the cellular leve…

  Authors: Geng Liu, John M Parant, Gene Lang, Patty Chau, Arturo Chavez-Reyes, Adel K El-Naggar, Asha Multani, Sandy Chang, Guillermina Lozano

  Source: Nature genetics. 2004 Jan

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• Loss of Mdm4 results in p53-dependent dilated cardiomyopathy.

  BACKGROUND: Although several loci for familial dilated cardiomyopathy (DCM) have been mapped, the origin of a large percentage of DCM remains unclear.…

  Authors: Shunbin Xiong, Carolyn S Van Pelt, Ana C Elizondo-Fraire, Belen Fernandez-Garcia, Guillermina Lozano

  Source: Circulation. 2007 Jun 12

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• EWS-FLI1 induces developmental abnormalities and accelerates sarcoma formation in a transgenic mouse model.

  Ewing's sarcoma is characterized by the t(11;22)(q24:q12) reciprocal translocation. To study the effects of the fusion gene EWS-FLI1 on development an…

  Authors: Patrick P Lin, Manoj K Pandey, Fenghua Jin, Shunbin Xiong, Michael Deavers, John M Parant, Guillermina Lozano

  Source: Cancer research. 2008 Nov 1

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• A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans.

  The tumor suppressor p53 gene is mutated in minimally half of all cancers. It is therefore reasonable to assume that naturally occurring polymorphic g…

  Authors: Gareth L Bond, Wenwei Hu, Elisabeth E Bond, Harlan Robins, Stuart G Lutzker, Nicoleta C Arva, Jill Bargonetti, Frank Bartel, Helge Taubert, Peter Wuerl,…

  Source: Cell. 2004 Nov 24

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