1 to 10 of 18 literature results

• A novel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14.

  Lysosome-related organelles have versatile functions, including protein and lipid degradation, signal transduction and protein secretion. The molecula…

  Authors: Georg Bohn, Anna Allroth, Gudrun Brandes, Jens Thiel, Erik Glocker, Alejandro A Schäffer, Chozhavendan Rathinam, Nicole Taub, David Teis, Cornelia Zeidler,…

  Source: Nature medicine. 2007 Jan

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• Argyrin a reveals a critical role for the tumor suppressor protein p27(kip1) in mediating antitumor activities in response to proteasome inhibition.

  A reduction in the cellular levels of the cyclin kinase inhibitor p27(kip1) is frequently found in many human cancers and correlates directly with pat…

  Authors: Irina Nickeleit, Steffen Zender, Florenz Sasse, Robert Geffers, Gudrun Brandes, Inga Sörensen, Heinrich Steinmetz, Stefan Kubicka, Teresa Carlomagno, Dirk Menche,…

  Source: Cancer cell. 2008 Jul 8

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• Preclinical testing of tissue-engineered heart valves re-endothelialized under simulated physiological conditions.

  BACKGROUND: The in vivo regeneration capacity of decellularized heart valve grafts is still controversial. The aim of this study was to evaluate funct…

  Authors: Artur Lichtenberg, Igor Tudorache, Serghei Cebotari, Mark Suprunov, Greta Tudorache, Heidi Goerler, Joon-Keun Park, Denise Hilfiker-Kleiner, Stefanie Ringes-Lichtenberg, Matthias Karck,…

  Source: Circulation. 2006 Jul 4

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• Identification of a homozygous deletion in the AP3B1 gene causing Hermansky-Pudlak syndrome, type 2.

  We report on the molecular etiology of an unusual clinical phenotype associating congenital neutropenia, thrombocytopenia, developmental delay, and hy…

  Authors: Johannes Jung, Georg Bohn, Anna Allroth, Kaan Boztug, Gudrun Brandes, Inga Sandrock, Alejandro A Schäffer, Chozhavendan Rathinam, Inga Köllner, Carmela Beger,…

  Source: Blood. 2006 Jul 1

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• Multiple roles of Pseudomonas aeruginosa TBCF10839 PilY1 in motility, transport and infection.

  Polymorphonuclear neutrophils are the most important mammalian host defence cells against infections with Pseudomonas aeruginosa. Screening of a signa…

  Authors: Yu-Sing Tammy Bohn, Gudrun Brandes, Elza Rakhimova, Sonja Horatzek, Prabhakar Salunkhe, Antje Munder, Andrea van Barneveld, Doris Jordan, Florian Bredenbruch, Susanne Häussler,…

  Source: Molecular microbiology. 2009 Feb

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• Phagocytosis of O4+ axonal fragments in vitro by p75- neonatal rat olfactory ensheathing cells.

  Olfactory ensheathing cells (OECs) have gained wide interest because of their unique regeneration-promoting capacity. However, despite their frequent …

  Authors: Konstantin Wewetzer, Norman Kern, Christian Ebel, Christine Radtke, Gudrun Brandes

  Source: Glia. 2005 Mar

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• Clostridium difficile toxins A and B directly stimulate human mast cells.

  Clostridium difficile toxins A and B (TcdA and TcdB) are the causative agents of antibiotic-associated pseudomembranous colitis. Mucosal mast cells pl…

  Authors: Gesa K A Meyer, Anne Neetz, Gudrun Brandes, Dimitrios Tsikas, Joseph H Butterfield, Ingo Just, Ralf Gerhard

  Source: Infection and immunity. 2007 Aug

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• Host cell responses to Chlamydia pneumoniae in gamma interferon-induced persistence overlap those of productive infection and are linked to genes involved in apoptosis, cell cycle, and metabolism.

  The respiratory pathogen Chlamydia (Chlamydophila) pneumoniae is associated with chronic diseases, including atherosclerosis and giant-cell arteritis,…

  Authors: Meike Eickhoff, Jessica Thalmann, Simone Hess, Myriam Martin, Thomas Laue, Joachim Kruppa, Gudrun Brandes, Andreas Klos

  Source: Infection and immunity. 2007 Jun

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• Orthotopic replacement of the aortic valve with decellularized allograft in a sheep model.

  Tissue engineered (TE) allografts have been successfully applied in pulmonary circulation. The behavior of TE valves based on decellularized scaffolds…

  Authors: Hassina Baraki, Igor Tudorache, Maike Braun, Klaus Höffler, Adelheid Görler, Artur Lichtenberg, Christopher Bara, Alex Calistru, Gudrun Brandes, Marion Hewicker-Trautwein,…

  Source: Biomaterials. 2009 Oct

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• In vitro re-endothelialization of detergent decellularized heart valves under simulated physiological dynamic conditions.

  The production of viable biological heart valves is of central interest in tissue engineering (TE). The aim of this study was to generate decellulariz…

  Authors: Artur Lichtenberg, Igor Tudorache, Serghei Cebotari, Stefanie Ringes-Lichtenberg, Gerrit Sturz, Klaus Hoeffler, Christof Hurscheler, Gudrun Brandes, Andres Hilfiker, Axel Haverich

  Source: Biomaterials. 2006 Aug

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