1 to 10 of 13 literature results

• Autophagy suppresses tumorigenesis through elimination of p62.

  Allelic loss of the essential autophagy gene beclin1 occurs in human cancers and renders mice tumor-prone suggesting that autophagy is a tumor-suppres…

  Authors: Robin Mathew, Cristina M Karp, Brian Beaudoin, Nhan Vuong, Guanghua Chen, Hsin-Yi Chen, Kevin Bray, Anupama Reddy, Gyan Bhanot, Celine Gelinas,…

  Source: Cell. 2009 Jun 12

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• Autophagy mitigates metabolic stress and genome damage in mammary tumorigenesis.

  Autophagy is a catabolic process involving self-digestion of cellular organelles during starvation as a means of cell survival; however, if it proceed…

  Authors: Vassiliki Karantza-Wadsworth, Shyam Patel, Olga Kravchuk, Guanghua Chen, Robin Mathew, Shengkan Jin, Eileen White

  Source: Genes & development. 2007 Jul 1

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• Autophagy suppresses tumor progression by limiting chromosomal instability.

  Autophagy is a bulk degradation process that promotes survival under metabolic stress, but it can also be a means of cell death if executed to complet…

  Authors: Robin Mathew, Sameera Kongara, Brian Beaudoin, Cristina M Karp, Kevin Bray, Kurt Degenhardt, Guanghua Chen, Shengkan Jin, Eileen White

  Source: Genes & development. 2007 Jun 1

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• Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis.

  Defective apoptosis renders immortalized epithelial cells highly tumorigenic, but how this is impacted by other common tumor mutations is not known. I…

  Authors: Kurt Degenhardt, Robin Mathew, Brian Beaudoin, Kevin Bray, Diana Anderson, Guanghua Chen, Chandreyee Mukherjee, Yufang Shi, Céline Gélinas, Yongjun Fan,…

  Source: Cancer cell. 2006 Jul

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• BAX and BAK mediate p53-independent suppression of tumorigenesis.

  BAX and BAK are essential regulators of proapoptotic signaling, and the disruption of apoptosis is linked to the development of cancer. To investigate…

  Authors: Kurt Degenhardt, Guanghua Chen, Tullia Lindsten, Eileen White

  Source: Cancer cell. 2002 Sep

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• Caspase-dependent processing activates the proapoptotic activity of deleted in breast cancer-1 during tumor necrosis factor-alpha-mediated death signaling.

  Deleted in breast cancer-1 (DBC-1) was initially cloned from a homozygously deleted region in breast and other cancers on human chromosome 8p21, altho…

  Authors: Ramya Sundararajan, Guanghua Chen, Chandreyee Mukherjee, Eileen White

  Source: Oncogene. 2005 Jul 21

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• Upregulation of OX40-OX40 ligand system on T lymphocytes in patients with acute coronary syndromes.

  OBJECTIVE: To investigate whether upregulation of OX40-OX40 ligand (OX40L) system is related to stability of coronary atherosclerotic plaque in patien…

  Authors: JinChuan Yan, Guanghua Chen, Jie Gong, CuiPing Wang, Rongzeng Du

  Source: Journal of cardiovascular pharmacology. 2009 Nov

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• Multiple myeloma cells undergo differentiation upon exposure to rosiglitazone and all-trans retinoic acid.

  Activation of PPARgamma by its ligands has shown differentiating effects in solid tumors. However, few reports addressed its role in myeloma cells. Ou…

  Authors: Haiwen Huang, Depei Wu, Jinxiang Fu, Guanghua Chen

  Source: Leukemia & lymphoma. 2009 Jun

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• All-trans retinoic acid can intensify the growth inhibition and differentiation induction effect of rosiglitazone on multiple myeloma cells.

  OBJECTIVE: Activation of PPARgamma by its ligands has shown potential anti-neoplastic effects in solid tumors. In this study, we investigate the effec…

  Authors: Haiwen Huang, Depei Wu, Jinxiang Fu, Guanghua Chen, Weirong Chang, Howard C H Chow, Anskar Y H Leung, Raymond Liang

  Source: European journal of haematology. 2009 Sep

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• Combination of DNA methylation inhibitor 5-azacytidine and arsenic trioxide has synergistic activity in myeloma.

  XAF1 is a newly identified candidate tumour-suppressor gene that can antagonise XIAP and sensitise cells to cell death triggers. This study was undert…

  Authors: Guanghua Chen, Yi Wang, Haiwen Huang, Fengru Lin, Depei Wu, Aining Sun, Huirong Chang, Yufeng Feng

  Source: European journal of haematology. 2009 Mar

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