1 to 10 of 12 literature results

• Induction of hepatitis by JNK-mediated expression of TNF-alpha.

  The c-Jun NH(2)-terminal kinase (JNK) signaling pathway has been implicated in the development of tumor necrosis factor (TNF)-dependent hepatitis. JNK…

  Authors: Madhumita Das, Guadalupe Sabio, Feng Jiang, Mercedes Rincón, Richard A Flavell, Roger J Davis

  Source: Cell. 2009 Jan 23

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• Role of muscle JNK1 in obesity-induced insulin resistance.

  Obesity caused by feeding a high fat diet (HFD) is associated with increased activation of cJun NH2-terminal kinase 1 (JNK1). Activated JNK1 is implic…

  Authors: Guadalupe Sabio, Norman J Kennedy, Julie Cavanagh-Kyros, Dae Young Jung, Hwi Jin Ko, Helena Ong, Tamera Barrett, Jason K Kim, Roger J Davis

  Source: Molecular and cellular biology. 2009 Oct 19

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• Lithium blocks the PKB and GSK3 dephosphorylation induced by ceramide through protein phosphatase-2A.

  The biochemical mechanism of apoptosis induced by ceramide remains still unclear, although it has been reported that dephosphorylation of PKB at Ser-4…

  Authors: Alfonso Mora, Guadalupe Sabio, Ana María Risco, Ana Cuenda, Juan C Alonso, Germán Soler, Francisco Centeno

  Source: Cellular signalling. 2002 Jun

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• Different dependence of lithium and valproate on PI3K/PKB pathway.

  OBJECTIVES: Acute treatment with valproate (VPA) or lithium (Li+) protects cerebellar granule cells (CGC) against apoptosis induced by low potassium (…

  Authors: Alfonso Mora, Guadalupe Sabio, Juan C Alonso, Germán Soler, Francisco Centeno

  Source: Bipolar disorders. 2002 Jun

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• Nuclear localization of p38 MAPK in response to DNA damage.

  p38 MAP kinase (MAPK) is activated in response to environmental stress, cytokines and DNA damage, and mediates death, cell differentiation and cell cy…

  Authors: C David Wood, Tina M Thornton, Guadalupe Sabio, Roger A Davis, Mercedes Rincon

  Source: International journal of biological sciences. 2009

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• Proteolysis of the tumour suppressor hDlg in response to osmotic stress is mediated by caspases and independent of phosphorylation.

  Human disc-large (hDlg) is a scaffold protein critical for the maintenance of cell polarity and adhesion. hDlg is a component of the p38gamma MAP kina…

  Authors: Francisco A Iñesta-Vaquera, Francisco Centeno, Paloma del Reino, Guadalupe Sabio, Mark Peggie, Ana Cuenda

  Source: The FEBS journal. 2009 Jan

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• A stress signaling pathway in adipose tissue regulates hepatic insulin resistance.

  A high-fat diet causes activation of the regulatory protein c-Jun NH2-terminal kinase 1 (JNK1) and triggers development of insulin resistance. JNK1 is…

  Authors: Guadalupe Sabio, Madhumita Das, Alfonso Mora, Zhiyou Zhang, John Y Jun, Hwi Jin Ko, Tamera Barrett, Jason K Kim, Roger J Davis

  Source: Science (New York, N.Y.). 2008 Dec 5

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• Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation.

  Glycogen synthase kinase 3beta (GSK3beta) is involved in metabolism, neurodegeneration, and cancer. Inhibition of GSK3beta activity is the primary mec…

  Authors: Tina M Thornton, Gustavo Pedraza-Alva, Bin Deng, C David Wood, Alexander Aronshtam, James L Clements, Guadalupe Sabio, Roger J Davis, Dwight E Matthews, Bradley Doble,…

  Source: Science (New York, N.Y.). 2008 May 2

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• Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response.

  Human arginase I is a potential target for therapeutic intervention in diseases linked to compromised l-arginine homeostasis. Here, we report high-aff…

  Authors: Luigi Di Costanzo, Guadalupe Sabio, Alfonso Mora, Paulo C Rodriguez, Augusto C Ochoa, Francisco Centeno, David W Christianson

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2005 Sep 13

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• BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo.

  The compound BIRB796 inhibits the stress-activated protein kinases p38alpha and p38beta and is undergoing clinical trials for the treatment of inflamm…

  Authors: Yvonne Kuma, Guadalupe Sabio, Jenny Bain, Natalia Shpiro, Rodolfo Márquez, Ana Cuenda

  Source: The Journal of biological chemistry. 2005 May 20

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