1 to 10 of 44 literature results

• Expression profiling in primates reveals a rapid evolution of human transcription factors.

  Although it has been hypothesized for thirty years that many human adaptations are likely to be due to changes in gene regulation, almost nothing is k…

  Authors: Yoav Gilad, Alicia Oshlack, Gordon K Smyth, Terence P Speed, Kevin P White

  Source: Nature. 2006 Mar 9

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• Generation of a functional mammary gland from a single stem cell.

  The existence of mammary stem cells (MaSCs) has been postulated from evidence that the mammary gland can be regenerated by transplantation of epitheli…

  Authors: Mark Shackleton, François Vaillant, Kaylene J Simpson, John Stingl, Gordon K Smyth, Marie-Liesse Asselin-Labat, Li Wu, Geoffrey J Lindeman, Jane E Visvader

  Source: Nature. 2006 Jan 5

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• Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers.

  Basal-like breast cancers arising in women carrying mutations in the BRCA1 gene, encoding the tumor suppressor protein BRCA1, are thought to develop f…

  Authors: Elgene Lim, François Vaillant, Di Wu, Natasha C Forrest, Bhupinder Pal, Adam H Hart, Marie-Liesse Asselin-Labat, David E Gyorki, Teresa Ward, Audrey Partanen,…

  Source: Nature medicine. 2009 Aug

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• The molecular signature of CD8+ T cells undergoing deletional tolerance.

  Peripheral tolerance induction is critical for the maintenance of self-tolerance and can be mediated by immunoregulatory T cells or by direct inductio…

  Authors: Ian A Parish, Sudha Rao, Gordon K Smyth, Torsten Juelich, Gareth S Denyer, Gayle M Davey, Andreas Strasser, William R Heath

  Source: Blood. 2009 May 7

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• Blimp1 is limiting for transformation in a mouse plasmacytoma model.

  Multiple myeloma (MM) and plasmacytomas are cancers of antibody-secreting cells (ASCs). PRDM1/BLIMP1 is an essential regulator of ASC development. His…

  Authors: Kathy D'Costa, Dianne Emslie, Donald Metcalf, Gordon K Smyth, Alexander Karnowski, Axel Kallies, Stephen L Nutt, Lynn M Corcoran

  Source: Blood. 2009 Jun 4

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• ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays.

  ELDA is a software application for limiting dilution analysis (LDA), with particular attention to the needs of stem cell assays. It is the first limit…

  Authors: Yifang Hu, Gordon K Smyth

  Source: Journal of immunological methods. 2009 Aug 15

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• Array-based gene discovery with three unrelated subjects shows SCARB2/LIMP-2 deficiency causes myoclonus epilepsy and glomerulosclerosis.

  Action myoclonus-renal failure syndrome (AMRF) is an autosomal-recessive disorder with the remarkable combination of focal glomerulosclerosis, frequen…

  Authors: Samuel F Berkovic, Leanne M Dibbens, Alicia Oshlack, Jeremy D Silver, Marina Katerelos, Danya F Vears, Renate Lüllmann-Rauch, Judith Blanz, Ke Wei Zhang, Jim Stankovich,…

  Source: American journal of human genetics. 2008 Mar

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• Molecular dissection of the pea shoot apical meristem.

  The shoot apical meristem (SAM) is responsible for the development of all the above-ground parts of a plant. Our understanding of the SAM at the molec…

  Authors: Dacheng Liang, Chui E Wong, Mohan B Singh, Christine A Beveridge, Belinda Phipson, Gordon K Smyth, Prem L Bhalla

  Source: Journal of experimental botany. 2009

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• Renal capsular leiomyoma.

  We report the case of a 54-year-old woman with an incidental finding of a left-sided renal mass for which she underwent a radical nephrectomy. Histolo…

  Authors: Aisling Hogan, Gordon K Smyth, Claire D'Arcy, Ann O'Brien, David M Quinlan

  Source: Urology. 2008 Jun

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• edgeR: a Bioconductor package for differential expression analysis of digital gene expression data.

  SUMMARY: It is expected that emerging digital gene expression (DGE) technologies will overtake microarray technologies in the near future for many fun…

  Authors: Mark D Robinson, Davis J McCarthy, Gordon K Smyth

  Source: Bioinformatics (Oxford, England). 2010 Jan 1

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