1 to 10 of 42 literature results

• Molecular diversity and regulation of renal potassium channels.

  K(+) channels are widely distributed in both plant and animal cells where they serve many distinct functions. K(+) channels set the membrane potential…

  Authors: Steven C Hebert, Gary Desir, Gerhard Giebisch, Wenhui Wang

  Source: Physiological reviews. 2005 Jan

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• Basolateral Na+/H+ exchange maintains potassium secretion during diminished sodium transport in the rabbit cortical collecting duct.

  Stimulation of the basolateral Na(+)/K(+)-ATPase in the isolated perfused rabbit cortical collecting duct by raising either bath potassium or lumen so…

  Authors: Shigeaki Muto, Shuichi Tsuruoka, Yukio Miyata, Akio Fujimura, Eiji Kusano, Wenhui Wang, Donald Seldin, Gerhard Giebisch

  Source: Kidney international. 2009 Jan

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• WNK4 regulates the balance between renal NaCl reabsorption and K+ secretion.

  A key question in systems biology is how diverse physiologic processes are integrated to produce global homeostasis. Genetic analysis can contribute b…

  Authors: Kristopher T Kahle, Frederick H Wilson, Qiang Leng, Maria D Lalioti, Anthony D O'Connell, Ke Dong, Alicia K Rapson, Gordon G MacGregor, Gerhard Giebisch, Steven C Hebert,…

  Source: Nature genetics. 2003 Dec

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• Homer W. Smith's contribution to renal physiology.

  Homer Smith was, for three decades, from the 1930s until his death in 1962, one of the leaders in the field of renal physiology. His contributions wer…

  Authors: Gerhard Giebisch

  Source: Journal of nephrology. 2004 Jan-Feb

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• Challenges to potassium metabolism: internal distribution and external balance.

  A complex pump-leak system involving both active and passive transport mechanisms is responsible for the appropriate distribution of potassium (K) bet…

  Authors: Gerhard Giebisch

  Source: Wiener klinische Wochenschrift. 2004 Jun 30

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• Presentation of the 2001 A.N. Richards Award to Eberhard Frömter.

  Authors: Gerhard Giebisch

  Source: Kidney international. 2003 Jun

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• Regulation of potassium (K) handling in the renal collecting duct.

  This review provides an overview of the molecular mechanisms of K transport in the mammalian connecting tubule (CNT) and cortical collecting duct (CCD…

  Authors: Wen-Hui Wang, Gerhard Giebisch

  Source: Pflügers Archiv : European journal of physiology. 2009 May

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• Src family protein tyrosine kinase (PTK) modulates the effect of SGK1 and WNK4 on ROMK channels.

  WNK4 (with no lysine kinase 4) inhibits ROMK channel activity in the distal nephron by stimulating clathrin-dependent endocytosis, an effect attenuate…

  Authors: Peng Yue, Dao-Hong Lin, Chun-Yang Pan, Qiang Leng, Gerhard Giebisch, Richard P Lifton, Wen-Hui Wang

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2009 Sep 1

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• Two classic papers in acid-base physiology: contributions of R. F. Pitts, R. S. Alexander, and W. D. Lotspeich.

  This essay looks at the historical significance of two APS classic papers that are freely available online: Pitts RF and Alexander RS. The nature of t…

  Authors: Gerhard Giebisch

  Source: American journal of physiology. Renal physiology. 2004 Nov

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• Female ROMK null mice manifest more severe Bartter II phenotype on renal function and higher PGE2 production.

  ROMK null mice with a high survival rate and varying severity of hydronephrosis provide a good model to study type II Bartter syndrome pathophysiology…

  Authors: Qingshang Yan, Xinbo Yang, Alessandra Cantone, Gerhard Giebisch, Steven Hebert, Tong Wang

  Source: American journal of physiology. Regulatory, integrative and comparative physiology. 2008 Sep

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