1 to 10 of 69 literature results

• A clinical perspective of rheumatoid arthritis.

  In recent years, factors potentially involved in pathogenesis of rheumatoid arthritis have mostly been identified by studying well-defined patient coh…

  Authors: Hans Ulrich Scherer, Gerd R Burmester

  Source: European journal of immunology. 2009 Aug

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• Kitasato symposium 2009: new prospects for cytokine inhibition.

  ABSTRACT : The Kitasato Symposium 2009: New Prospects for Cytokine Inhibition was held in Berlin, Germany from 7 to 9 May 2009. The key aims of this m…

  Authors: Gerd R Burmester, Peter E Lipsky, Thomas Dörner, Kitasato Meeting Faculty*

  Source: Arthritis research & therapy. 2009

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• Reactivation of rheumatoid arthritis after pregnancy: increased phagocyte and recurring lymphocyte gene activity.

  OBJECTIVE: Pregnancy is associated with reduced disease activity in rheumatoid arthritis (RA) and frequently with disease exacerbation after delivery.…

  Authors: Thomas Häupl, Monika Østensen, Andreas Grützkau, Andreas Radbruch, Gerd-R Burmester, Peter M Villiger

  Source: Arthritis and rheumatism. 2008 Oct

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• CTLA-4 (CD152) controls homeostasis and suppressive capacity of regulatory T cells in mice.

  OBJECTIVE: CD4+CD25+ regulatory T cells (known as Treg cells) suppress unwanted and autoreactive T cell responses. Treg cells express the costimulator…

  Authors: Paula Kolar, Karin Knieke, J Kolja E Hegel, Dagmar Quandt, Gerd-R Burmester, Holger Hoff, Monika C Brunner-Weinzierl

  Source: Arthritis and rheumatism. 2009 Jan

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• Clinical remission and/or minimal disease activity in patients receiving adalimumab treatment in a multinational, open-label, twelve-week study.

  OBJECTIVE: To evaluate the effect of adalimumab treatment on clinical remission and/or minimal disease activity (MDA) in 6,610 patients with active rh…

  Authors: Gerd R Burmester, Gianfranco Ferraccioli, René-Marc Flipo, Indalecio Monteagudo-Sáez, Kristina Unnebrink, Sonja Kary, Hartmut Kupper

  Source: Arthritis and rheumatism. 2008 Jan 15

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• Cells of the synovium in rheumatoid arthritis. Macrophages.

  The multitude and abundance of macrophage-derived mediators in rheumatoid arthritis and their paracrine/autocrine effects identify macrophages as loca…

  Authors: Raimund W Kinne, Bruno Stuhlmüller, Gerd-R Burmester

  Source: Arthritis research & therapy. 2007

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• Anticytokine therapy impacting on B cells in autoimmune diseases.

  PURPOSE OF REVIEW: To evaluate the impact of particular anticytokine therapies able to indirectly target B cells with emphasis on the tumor necrosis f…

  Authors: Capucine Daridon, Gerd R Burmester, Thomas Dörner

  Source: Current opinion in rheumatology. 2009 May

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• New approaches of B-cell-directed therapy: beyond rituximab.

  PURPOSE OF REVIEW: This study reviews therapeutic approaches of direct and indirect B-cell targeting in autoimmune diseases and their impact on protec…

  Authors: Thomas Dörner, Gerd R Burmester

  Source: Current opinion in rheumatology. 2008 May

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• Rapid and sustained improvements in health-related quality of life, fatigue, and other patient-reported outcomes in rheumatoid arthritis patients treated with certolizumab pegol plus methotrexate over 1 year: results from the RAPID 1 randomized controlled trial.

  ABSTRACT : INTRODUCTION : The objective of this study was to assess the impact of certolizumab pegol (CZP) treatment on health-related quality of life…

  Authors: Vibeke Strand, Philip Mease, Gerd R Burmester, Enkeleida Nikaï, Geoffroy Coteur, Ronald van Vollenhoven, Bernard Combe, Edward C Keystone, Arthur Kavanaugh

  Source: Arthritis research & therapy. 2009

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• Circulating proteasome levels are an independent prognostic factor for survival in multiple myeloma.

  The proteasome is a proteolytic complex for intracellular degradation of ubiquitinated proteins which are involved in cell-cycle regulation and apopto…

  Authors: Christian Jakob, Karl Egerer, Peter Liebisch, Seval Türkmen, Ivana Zavrski, Ulrike Kuckelkorn, Ulrike Heider, Martin Kaiser, Claudia Fleissner, Jan Sterz,…

  Source: Blood. 2007 Mar 1

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