1 to 10 of 126 literature results

• Lin28: A microRNA regulator with a macro role.

  Lin28, a highly conserved RNA-binding protein, has emerged as a modulator of the processing of the let-7 microRNA. This role for Lin28 has important i…

  Authors: Srinivas R Viswanathan, George Q Daley

  Source: Cell. 2010 Feb 19

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• Prospects for stem cell-based therapy.

  Resident pools of somatic stem cells in many organs are responsible for tissue maintenance and repair. The goal of regenerative medicine is to exploit…

  Authors: George Q Daley, David T Scadden

  Source: Cell. 2008 Feb 22

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• Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment.

  Osteoblasts and endothelium constitute functional niches that support haematopoietic stem cells in mammalian bone marrow. Adult bone marrow also conta…

  Authors: Olaia Naveiras, Valentina Nardi, Pamela L Wenzel, Peter V Hauschka, Frederic Fahey, George Q Daley

  Source: Nature. 2009 Jul 9

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• A role for Lin28 in primordial germ-cell development and germ-cell malignancy.

  The rarity and inaccessibility of the earliest primordial germ cells (PGCs) in the mouse embryo thwart efforts to investigate molecular mechanisms of …

  Authors: Jason A West, Srinivas R Viswanathan, Akiko Yabuuchi, Kerianne Cunniff, Ayumu Takeuchi, In-Hyun Park, Julia E Sero, Hao Zhu, Antonio Perez-Atayde, A Lindsay Frazier,…

  Source: Nature. 2009 Aug 13

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• Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients.

  Patients with dyskeratosis congenita (DC), a disorder of telomere maintenance, suffer degeneration of multiple tissues. Patient-specific induced pluri…

  Authors: Suneet Agarwal, Yuin-Han Loh, Erin M McLoughlin, Junjiu Huang, In-Hyun Park, Justine D Miller, Hongguang Huo, Maja Okuka, Rosana Maria Dos Reis, Sabine Loewer,…

  Source: Nature. 2010 Mar 11

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• Ras-MAPK signaling promotes trophectoderm formation from embryonic stem cells and mouse embryos.

  In blastocyst chimeras, embryonic stem (ES) cells contribute to embryonic tissues but not extraembryonic trophectoderm. Conditional activation of HRas…

  Authors: Chi-Wei Lu, Akiko Yabuuchi, Lingyi Chen, Srinivas Viswanathan, Kitai Kim, George Q Daley

  Source: Nature genetics. 2008 Jul

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• Chronic myeloid leukemia: proving ground for cancer stem cells.

  A central question in cancer biology is whether malignancy arises in self-renewing tissue stem cells that suffer oncogene activation or in differentia…

  Authors: George Q Daley

  Source: Cell. 2004 Oct 29

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• Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration.

  Interactions between developmental signaling pathways govern the formation and function of stem cells. Prostaglandin (PG) E2 regulates vertebrate hema…

  Authors: Wolfram Goessling, Trista E North, Sabine Loewer, Allegra M Lord, Sang Lee, Cristi L Stoick-Cooper, Gilbert Weidinger, Mark Puder, George Q Daley, Randall T Moon,…

  Source: Cell. 2009 Mar 20

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• Biomechanical forces promote embryonic haematopoiesis.

  Biomechanical forces are emerging as critical regulators of embryogenesis, particularly in the developing cardiovascular system. After initiation of t…

  Authors: Luigi Adamo, Olaia Naveiras, Pamela L Wenzel, Shannon McKinney-Freeman, Peter J Mack, Jorge Gracia-Sancho, Astrid Suchy-Dicey, Momoko Yoshimoto, M William Lensch, Mervin C Yoder,…

  Source: Nature. 2009 Jun 25

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• Reprogramming of human somatic cells to pluripotency with defined factors.

  Pluripotency pertains to the cells of early embryos that can generate all of the tissues in the organism. Embryonic stem cells are embryo-derived cell…

  Authors: In-Hyun Park, Rui Zhao, Jason A West, Akiko Yabuuchi, Hongguang Huo, Tan A Ince, Paul H Lerou, M William Lensch, George Q Daley

  Source: Nature. 2008 Jan 10

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