1 to 10 of 69 literature results

• Enteric defensins are essential regulators of intestinal microbial ecology.

  Antimicrobial peptides are important effectors of innate immunity throughout the plant and animal kingdoms. In the mammalian small intestine, Paneth c…

  Authors: Nita H Salzman, Kuiechun Hung, Dipica Haribhai, Hiutung Chu, Jenny Karlsson-Sjöberg, Elad Amir, Paul Teggatz, Melissa Barman, Michael Hayward, Daniel Eastwood,…

  Source: Nature immunology. 2010 Jan

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• The complete genome of an individual by massively parallel DNA sequencing.

  The association of genetic variation with disease and drug response, and improvements in nucleic acid technologies, have given great optimism for the …

  Authors: David A Wheeler, Maithreyan Srinivasan, Michael Egholm, Yufeng Shen, Lei Chen, Amy McGuire, Wen He, Yi-Ju Chen, Vinod Makhijani, G Thomas Roth,…

  Source: Nature. 2008 Apr 17

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• Genome remodelling in a basal-like breast cancer metastasis and xenograft.

  Massively parallel DNA sequencing technologies provide an unprecedented ability to screen entire genomes for genetic changes associated with tumour pr…

  Authors: Li Ding, Matthew J Ellis, Shunqiang Li, David E Larson, Ken Chen, John W Wallis, Christopher C Harris, Michael D McLellan, Robert S Fulton, Lucinda L Fulton,…

  Source: Nature. 2010 Apr 15

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• A SNP discovery method to assess variant allele probability from next-generation resequencing data.

  Accurate identification of genetic variants from next-generation sequencing (NGS) data is essential for immediate large-scale genomic endeavors such a…

  Authors: Yufeng Shen, Zhengzheng Wan, Cristian Coarfa, Rafal Drabek, Lei Chen, Elizabeth A Ostrowski, Yue Liu, George M Weinstock, David A Wheeler, Richard A Gibbs,…

  Source: Genome research. 2010 Feb

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• The genome of the model beetle and pest Tribolium castaneum.

  Tribolium castaneum is a member of the most species-rich eukaryotic order, a powerful model organism for the study of generalized insect development, …

  Authors: Tribolium Genome Sequencing Consortium, Stephen Richards, Richard A Gibbs, George M Weinstock, Susan J Brown, Robin Denell, Richard W Beeman, Richard Gibbs, Richard W Beeman, Susan J Brown,…

  Source: Nature. 2008 Apr 24

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• Somatic mutations affect key pathways in lung adenocarcinoma.

  Determining the genetic basis of cancer requires comprehensive analyses of large collections of histopathologically well-classified primary tumours. H…

  Authors: Li Ding, Gad Getz, David A Wheeler, Elaine R Mardis, Michael D McLellan, Kristian Cibulskis, Carrie Sougnez, Heidi Greulich, Donna M Muzny, Margaret B Morgan,…

  Source: Nature. 2008 Oct 23

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• A high-throughput percentage-of-binding strategy to measure binding energies in DNA-protein interactions: application to genome-scale site discovery.

  Quantifying the binding energy in DNA-protein interactions is of critical importance to understand transcriptional regulation. Based on a simple compu…

  Authors: Xiaohu Wang, Haichun Gao, Yufeng Shen, George M Weinstock, Jizhong Zhou, Timothy Palzkill

  Source: Nucleic acids research. 2008 Sep

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• Characterizing the cancer genome in lung adenocarcinoma.

  Somatic alterations in cellular DNA underlie almost all human cancers. The prospect of targeted therapies and the development of high-resolution, geno…

  Authors: Barbara A Weir, Michele S Woo, Gad Getz, Sven Perner, Li Ding, Rameen Beroukhim, William M Lin, Michael A Province, Aldi Kraja, Laura A Johnson,…

  Source: Nature. 2007 Dec 6

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• ENCODE: more genomic empowerment.

  Authors: George M Weinstock

  Source: Genome research. 2007 Jun

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• Phylogenomic analysis reveals bees and wasps (Hymenoptera) at the base of the radiation of Holometabolous insects.

  Comparative studies require knowledge of the evolutionary relationships between taxa. However, neither morphological nor paleontological data have bee…

  Authors: Joël Savard, Diethard Tautz, Stephen Richards, George M Weinstock, Richard A Gibbs, John H Werren, Hervé Tettelin, Martin J Lercher

  Source: Genome research. 2006 Nov

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