1 to 10 of 59 literature results

• Phenotypic variations on the theme of CNVs.

  Authors: Michael C O'Donovan, George Kirov, Michael J Owen

  Source: Nature genetics. 2008 Dec

  View Full Text

• Support for the involvement of large copy number variants in the pathogenesis of schizophrenia.

  We investigated the involvement of rare (<1%) copy number variants (CNVs) in 471 cases of schizophrenia and 2792 controls that had been genotyped usin…

  Authors: George Kirov, Detelina Grozeva, Nadine Norton, Dobril Ivanov, Kiran K Mantripragada, Peter Holmans, International Schizophrenia Consortium, Wellcome Trust Case Control Consortium, Nick Craddock, Michael J Owen,…

  Source: Human molecular genetics. 2009 Apr 15

  View Full Text

• Identification of loci associated with schizophrenia by genome-wide association and follow-up.

  We carried out a genome-wide association study of schizophrenia (479 cases, 2,937 controls) and tested loci with P < 10(-5) in up to 16,726 additional…

  Authors: Michael C O'Donovan, Nicholas Craddock, Nadine Norton, Hywel Williams, Timothy Peirce, Valentina Moskvina, Ivan Nikolov, Marian Hamshere, Liam Carroll, Lyudmila Georgieva,…

  Source: Nature genetics. 2008 Sep

  View Full Text

• Microduplications of 16p11.2 are associated with schizophrenia.

  Recurrent microdeletions and microduplications of a 600-kb genomic region of chromosome 16p11.2 have been implicated in childhood-onset developmental …

  Authors: Shane E McCarthy, Vladimir Makarov, George Kirov, Anjene M Addington, Jon McClellan, Seungtai Yoon, Diana O Perkins, Diane E Dickel, Mary Kusenda, Olga Krastoshevsky,…

  Source: Nature genetics. 2009 Nov

  View Full Text

• Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.

  To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of stro…

  Authors: Manuel A R Ferreira, Michael C O'Donovan, Yan A Meng, Ian R Jones, Douglas M Ruderfer, Lisa Jones, Jinbo Fan, George Kirov, Roy H Perlis, Elaine K Green,…

  Source: Nature genetics. 2008 Sep

  View Free Full Text

• Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia.

  Copy number variations (CNVs) account for a substantial proportion of human genomic variation, and have been shown to cause neurodevelopmental disorde…

  Authors: George Kirov, Dilihan Gumus, Wei Chen, Nadine Norton, Lyudmila Georgieva, Murat Sari, Michael C O'Donovan, Fikret Erdogan, Michael J Owen, Hans-Hilger Ropers,…

  Source: Human molecular genetics. 2008 Feb 1

  View Full Text

• Copy Number Variation in Schizophrenia in the Japanese Population.

  BACKGROUND: Copy number variants (CNVs) have been shown to increase the risk to develop schizophrenia. The best supported findings are at 1q21.1, 15q1…

  Authors: Masashi Ikeda, Branko Aleksic, George Kirov, Yoko Kinoshita, Yoshio Yamanouchi, Tsuyoshi Kitajima, Kunihiro Kawashima, Tomo Okochi, Taro Kishi, Irina Zaharieva,…

  Source: Biological psychiatry. 2009 Oct 30

  View Full Text

• Strong evidence that GNB1L is associated with schizophrenia.

  Evidence that a gene or genes on chromosome 22 is involved in susceptibility to schizophrenia comes from two sources: the increased incidence of schiz…

  Authors: Nigel M Williams, Beate Glaser, Nadine Norton, Hywel Williams, Timothy Pierce, Valentina Moskvina, Stephen Monks, Jurgen Del Favero, Dirk Goossens, Dan Rujescu,…

  Source: Human molecular genetics. 2008 Feb 15

  View Full Text

• A network of dopaminergic gene variations implicated as risk factors for schizophrenia.

  We evaluated the hypothesis that dopaminergic polymorphisms are risk factors for schizophrenia (SZ). In stage I, we screened 18 dopamine-related genes…

  Authors: Michael E Talkowski, George Kirov, Mikhil Bamne, Lyudmila Georgieva, Gonzalo Torres, Hader Mansour, Kodavali V Chowdari, Vihra Milanova, Joel Wood, Lora McClain,…

  Source: Human molecular genetics. 2008 Mar 1

  View Full Text

• Variation at the DAOA/G30 locus influences susceptibility to major mood episodes but not psychosis in schizophrenia and bipolar disorder.

  CONTEXT: Variation at the DAOA/G30 locus has been described to be associated with both schizophrenia and bipolar disorder, but there is little consist…

  Authors: Nigel M Williams, Elaine K Green, Stuart Macgregor, Sarah Dwyer, Nadine Norton, Hywel Williams, Rachel Raybould, Detelina Grozeva, Marian Hamshere, Stanley Zammit,…

  Source: Archives of general psychiatry. 2006 Apr

  View Full Text