1 to 5 of 5 literature results

• Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.

  Adipocyte fatty-acid-binding protein, aP2 (FABP4) is expressed in adipocytes and macrophages, and integrates inflammatory and metabolic responses. Stu…

  Authors: Masato Furuhashi, Gürol Tuncman, Cem Z Görgün, Liza Makowski, Genichi Atsumi, Eric Vaillancourt, Keita Kono, Vladimir R Babaev, Sergio Fazio, MacRae F Linton,…

  Source: Nature. 2007 Jun 21

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• A central role for JNK in obesity and insulin resistance.

  Obesity is closely associated with insulin resistance and establishes the leading risk factor for type 2 diabetes mellitus, yet the molecular mechanis…

  Authors: Jiro Hirosumi, Gürol Tuncman, Lufen Chang, Cem Z Görgün, K Teoman Uysal, Kazuhisa Maeda, Michael Karin, Gökhan S Hotamisligil

  Source: Nature. 2002 Nov 21

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• Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice.

  Adipose tissue inflammation is a characteristic of obesity. However, the mechanisms that regulate this inflammatory response and link adipose inflamma…

  Authors: Masato Furuhashi, Raquel Fucho, Cem Z Görgün, Gürol Tuncman, Haiming Cao, Gökhan S Hotamisligil

  Source: The Journal of clinical investigation. 2008 Jul

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• Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance.

  The c-Jun N-terminal kinases (JNKs) are key regulators of inflammation and interfere with insulin action in cultured cells and whole animals. Obesity …

  Authors: Gürol Tuncman, Jiro Hirosumi, Giovanni Solinas, Lufen Chang, Michael Karin, Gökhan S Hotamisligil

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2006 Jul 11

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• Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.

  Obesity contributes to the development of type 2 diabetes, but the underlying mechanisms are poorly understood. Using cell culture and mouse models, w…

  Authors: Umut Ozcan, Qiong Cao, Erkan Yilmaz, Ann-Hwee Lee, Neal N Iwakoshi, Esra Ozdelen, Gürol Tuncman, Cem Görgün, Laurie H Glimcher, Gökhan S Hotamisligil

  Source: Science (New York, N.Y.). 2004 Oct 15

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