1 to 10 of 54 literature results

• Inflammation and metabolic disorders.

  Metabolic and immune systems are among the most fundamental requirements for survival. Many metabolic and immune response pathways or nutrient- and pa…

  Authors: Gökhan S Hotamisligil

  Source: Nature. 2006 Dec 14

  View Full Text

• Stressing the brain, fattening the body.

  Obesity is characterized by chronic activation of inflammatory pathways in peripheral tissues. In this issue, Zhang et al. (2008) demonstrate that inf…

  Authors: Ling Yang, Gökhan S Hotamisligil

  Source: Cell. 2008 Oct 3

  View Full Text

• Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis.

  As chronic inflammation is a hallmark of obesity, pathways that integrate nutrient- and pathogen sensing pathways are of great interest in understandi…

  Authors: Takahisa Nakamura, Masato Furuhashi, Ping Li, Haiming Cao, Gurol Tuncman, Nahum Sonenberg, Cem Z Gorgun, Gökhan S Hotamisligil

  Source: Cell. 2010 Feb 5

  View Full Text

• Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis.

  Macrophages show endoplasmic reticulum (ER) stress when exposed to lipotoxic signals associated with atherosclerosis, although the pathophysiological …

  Authors: Ebru Erbay, Vladimir R Babaev, Jared R Mayers, Liza Makowski, Khanichi N Charles, Melinda E Snitow, Sergio Fazio, Michelle M Wiest, Steven M Watkins, Macrae F Linton,…

  Source: Nature medicine. 2009 Dec

  View Full Text

• Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism.

  Dysregulation of lipid metabolism in individual tissues leads to systemic disruption of insulin action and glucose metabolism. Utilizing quantitative …

  Authors: Haiming Cao, Kristin Gerhold, Jared R Mayers, Michelle M Wiest, Steven M Watkins, Gökhan S Hotamisligil

  Source: Cell. 2008 Sep 19

  View Free Full Text

• Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice.

  Although mast cell functions have classically been related to allergic responses, recent studies indicate that these cells contribute to other common …

  Authors: Jian Liu, Adeline Divoux, Jiusong Sun, Jie Zhang, Karine Clément, Jonathan N Glickman, Galina K Sukhova, Paul J Wolters, Juan Du, Cem Z Gorgun,…

  Source: Nature medicine. 2009 Aug

  View Free Full Text

• Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.

  Adipocyte fatty-acid-binding protein, aP2 (FABP4) is expressed in adipocytes and macrophages, and integrates inflammatory and metabolic responses. Stu…

  Authors: Masato Furuhashi, Gürol Tuncman, Cem Z Görgün, Liza Makowski, Genichi Atsumi, Eric Vaillancourt, Keita Kono, Vladimir R Babaev, Sergio Fazio, MacRae F Linton,…

  Source: Nature. 2007 Jun 21

  View Full Text

• Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis.

  Mammalian target of rapamycin, mTOR, is a major sensor of nutrient and energy availability in the cell and regulates a variety of cellular processes, …

  Authors: Umut Ozcan, Lale Ozcan, Erkan Yilmaz, Katrin Düvel, Mustafa Sahin, Brendan D Manning, Gökhan S Hotamisligil

  Source: Molecular cell. 2008 Mar 14

  View Free Full Text

• Coordinated regulation of nutrient and inflammatory responses by STAMP2 is essential for metabolic homeostasis.

  Metabolic and inflammatory pathways crosstalk at many levels, and, while required for homeostasis, interaction between these pathways can also lead to…

  Authors: Kathryn E Wellen, Raquel Fucho, Margaret F Gregor, Masato Furuhashi, Carlos Morgan, Torstein Lindstad, Eric Vaillancourt, Cem Z Gorgun, Fahri Saatcioglu, Gökhan S Hotamisligil

  Source: Cell. 2007 May 4

  View Free Full Text

• Developmental biology: cell fate in the mammary gland.

  Authors: Qiang Tong, Gökhan S Hotamisligil

  Source: Nature. 2007 Feb 15

  View Full Text