1 to 9 of 9 literature results

• Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis.

  As chronic inflammation is a hallmark of obesity, pathways that integrate nutrient- and pathogen sensing pathways are of great interest in understandi…

  Authors: Takahisa Nakamura, Masato Furuhashi, Ping Li, Haiming Cao, Gurol Tuncman, Nahum Sonenberg, Cem Z Gorgun, Gökhan S Hotamisligil

  Source: Cell. 2010 Feb 5

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• Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2.

  Adipocyte fatty-acid-binding protein, aP2 (FABP4) is expressed in adipocytes and macrophages, and integrates inflammatory and metabolic responses. Stu…

  Authors: Masato Furuhashi, Gürol Tuncman, Cem Z Görgün, Liza Makowski, Genichi Atsumi, Eric Vaillancourt, Keita Kono, Vladimir R Babaev, Sergio Fazio, MacRae F Linton,…

  Source: Nature. 2007 Jun 21

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• A central role for JNK in obesity and insulin resistance.

  Obesity is closely associated with insulin resistance and establishes the leading risk factor for type 2 diabetes mellitus, yet the molecular mechanis…

  Authors: Jiro Hirosumi, Gürol Tuncman, Lufen Chang, Cem Z Görgün, K Teoman Uysal, Kazuhisa Maeda, Michael Karin, Gökhan S Hotamisligil

  Source: Nature. 2002 Nov 21

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• Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice.

  Adipose tissue inflammation is a characteristic of obesity. However, the mechanisms that regulate this inflammatory response and link adipose inflamma…

  Authors: Masato Furuhashi, Raquel Fucho, Cem Z Görgün, Gürol Tuncman, Haiming Cao, Gökhan S Hotamisligil

  Source: The Journal of clinical investigation. 2008 Jul

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• Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance.

  The c-Jun N-terminal kinases (JNKs) are key regulators of inflammation and interfere with insulin action in cultured cells and whole animals. Obesity …

  Authors: Gürol Tuncman, Jiro Hirosumi, Giovanni Solinas, Lufen Chang, Michael Karin, Gökhan S Hotamisligil

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2006 Jul 11

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• A genetic variant at the fatty acid-binding protein aP2 locus reduces the risk for hypertriglyceridemia, type 2 diabetes, and cardiovascular disease.

  Obesity and the associated pathologies including dyslipidemia, insulin resistance, type 2 diabetes, and cardiovascular disease constitute a major thre…

  Authors: G Tuncman, E Erbay, X Hom, I De Vivo, H Campos, E B Rimm, G S Hotamisligil

  Source: Proceedings of the National Academy of Sciences of the United States of America. 2006 May 2

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• Divergent roles for p55 and p75 TNF-alpha receptors in the induction of plasminogen activator inhibitor-1.

  Tumor necrosis factor-alpha (TNF-alpha) is elevated in obesity and in acute inflammatory states, and contributes to the elevated plasminogen activator…

  Authors: Manjula Pandey, Gurol Tuncman, Gökhan S Hotamisligil, Fahumiya Samad

  Source: The American journal of pathology. 2003 Mar

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• Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes.

  Obesity contributes to the development of type 2 diabetes, but the underlying mechanisms are poorly understood. Using cell culture and mouse models, w…

  Authors: Umut Ozcan, Qiong Cao, Erkan Yilmaz, Ann-Hwee Lee, Neal N Iwakoshi, Esra Ozdelen, Gürol Tuncman, Cem Görgün, Laurie H Glimcher, Gökhan S Hotamisligil

  Source: Science (New York, N.Y.). 2004 Oct 15

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• Molecular alterations in the TP53 gene of peripheral blood cells of patients with chronic myeloid leukemia.

  The TP53 gene has been extensively studied in patients with chronic myeloid leukemia (CML), both in chronic phase and in blast crisis. Mutations in th…

  Authors: S Peller, R Yona, Y Kopilova, M Prokocimer, N Goldfinger, A Uysal, H G Karabulut, A Tukun, I Bokesoy, G Tuncman,…

  Source: Genes, chromosomes & cancer. 1998 Jan

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