1 to 10 of 18 literature results

• Induction of hepatitis by JNK-mediated expression of TNF-alpha.

  The c-Jun NH(2)-terminal kinase (JNK) signaling pathway has been implicated in the development of tumor necrosis factor (TNF)-dependent hepatitis. JNK…

  Authors: Madhumita Das, Guadalupe Sabio, Feng Jiang, Mercedes Rincón, Richard A Flavell, Roger J Davis

  Source: Cell. 2009 Jan 23

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• Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1.

  The cJun N-terminal kinase 1 (JNK1) is implicated in diet-induced obesity. Indeed, germline ablation of the murine Jnk1 gene prevents diet-induced obe…

  Authors: Guadalupe Sabio, Julie Cavanagh-Kyros, Tamera Barrett, Dae Young Jung, Hwi Jin Ko, Helena Ong, Caroline Morel, Alfonso Mora, Judith Reilly, Jason K Kim,…

  Source: Genes & development. 2010 Feb 1

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• Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance.

  Obesity caused by feeding of a high-fat diet (HFD) is associated with an increased activation of c-Jun NH(2)-terminal kinase 1 (JNK1). Activated JNK1 …

  Authors: Guadalupe Sabio, Norman J Kennedy, Julie Cavanagh-Kyros, Dae Young Jung, Hwi Jin Ko, Helena Ong, Tamera Barrett, Jason K Kim, Roger J Davis

  Source: Molecular and cellular biology. 2010 Jan

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• Differential activation of p38MAPK isoforms by MKK6 and MKK3.

  All four members of the mammalian p38 mitogen-activated protein kinase (MAPK) family (p38alpha, p38beta, p38gamma and p38delta) are activated by dual …

  Authors: Gaëlle Remy, Ana M Risco, Francisco A Iñesta-Vaquera, Bárbara González-Terán, Guadalupe Sabio, Roger J Davis, Ana Cuenda

  Source: Cellular signalling. 2010 Apr

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• Lithium blocks the PKB and GSK3 dephosphorylation induced by ceramide through protein phosphatase-2A.

  The biochemical mechanism of apoptosis induced by ceramide remains still unclear, although it has been reported that dephosphorylation of PKB at Ser-4…

  Authors: Alfonso Mora, Guadalupe Sabio, Ana María Risco, Ana Cuenda, Juan C Alonso, Germán Soler, Francisco Centeno

  Source: Cellular signalling. 2002 Jun

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• Different dependence of lithium and valproate on PI3K/PKB pathway.

  OBJECTIVES: Acute treatment with valproate (VPA) or lithium (Li+) protects cerebellar granule cells (CGC) against apoptosis induced by low potassium (…

  Authors: Alfonso Mora, Guadalupe Sabio, Juan C Alonso, Germán Soler, Francisco Centeno

  Source: Bipolar disorders. 2002 Jun

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• Nuclear localization of p38 MAPK in response to DNA damage.

  p38 MAP kinase (MAPK) is activated in response to environmental stress, cytokines and DNA damage, and mediates death, cell differentiation and cell cy…

  Authors: C David Wood, Tina M Thornton, Guadalupe Sabio, Roger A Davis, Mercedes Rincon

  Source: International journal of biological sciences. 2009

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• Lithium inhibits caspase 3 activation and dephosphorylation of PKB and GSK3 induced by K+ deprivation in cerebellar granule cells.

  Lithium protects cerebellar granule cells from apoptosis induced by low potassium, and also from other apoptotic stimuli. However, the precise mechani…

  Authors: A Mora, G Sabio, R A González-Polo, A Cuenda, D R Alessi, J C Alonso, J M Fuentes, G Soler, F Centeno

  Source: Journal of neurochemistry. 2001 Jul

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• Proteolysis of the tumour suppressor hDlg in response to osmotic stress is mediated by caspases and independent of phosphorylation.

  Human disc-large (hDlg) is a scaffold protein critical for the maintenance of cell polarity and adhesion. hDlg is a component of the p38gamma MAP kina…

  Authors: Francisco A Iñesta-Vaquera, Francisco Centeno, Paloma del Reino, Guadalupe Sabio, Mark Peggie, Ana Cuenda

  Source: The FEBS journal. 2009 Jan

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• Mechanisms of MPP(+) incorporation into cerebellar granule cells.

  Exposure of cerebellar granule cells to 1-methyl-4-phenylpiridinium (MPP(+)) results in cell death. We have studied the implication of various membran…

  Authors: R A González-Polo, A Mora, N Clemente, G Sabio, F Centeno, G Soler, J M Fuentes

  Source: Brain research bulletin. 2001 Sep 15

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