1 to 10 of 277 literature results

• A degron created by SMN2 exon 7 skipping is a principal contributor to spinal muscular atrophy severity.

  Spinal muscular atrophy (SMA) is caused by homozygous survival of motor neurons 1 (SMN1) gene deletions, leaving a duplicate gene, SMN2, as the sole s…

  Authors: Sungchan Cho, Gideon Dreyfuss

  Source: Genes & development. 2010 Mar 1

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• RNA and disease.

  Cellular functions depend on numerous protein-coding and noncoding RNAs and the RNA-binding proteins associated with them, which form ribonucleoprotei…

  Authors: Thomas A Cooper, Lili Wan, Gideon Dreyfuss

  Source: Cell. 2009 Feb 20

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• tRNA Binds to Cytochrome c and Inhibits Caspase Activation.

  The specific molecular events that characterize the intrinsic apoptosis pathway have been the subject of intense research due to the pathway's fundame…

  Authors: Yide Mei, Jeongsik Yong, Hongtu Liu, Yigong Shi, Judy Meinkoth, Gideon Dreyfuss, Xiaolu Yang

  Source: Molecular cell. 2010 Mar 12

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• SMN deficiency causes tissue-specific perturbations in the repertoire of snRNAs and widespread defects in splicing.

  The survival of motor neurons (SMN) protein is essential for the biogenesis of small nuclear RNA (snRNA)-ribonucleoproteins (snRNPs), the major compon…

  Authors: Zhenxi Zhang, Francesco Lotti, Kimberly Dittmar, Ihab Younis, Lili Wan, Mumtaz Kasim, Gideon Dreyfuss

  Source: Cell. 2008 May 16

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• Inactivation of the SMN complex by oxidative stress.

  The SMN complex is essential for the biogenesis of small nuclear ribonucleoproteins (snRNPs), the major constituents of the spliceosome. Deficiency in…

  Authors: Lili Wan, Elizabeth Ottinger, Sungchan Cho, Gideon Dreyfuss

  Source: Molecular cell. 2008 Jul 25

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• Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation.

  Here we identify a component of the nuclear RNA cap-binding complex (CBC), Ars2, that is important for miRNA biogenesis and critical for cell prolifer…

  Authors: Joshua J Gruber, D Steven Zatechka, Leah R Sabin, Jeongsik Yong, Julian J Lum, Mei Kong, Wei-Xing Zong, Zhenxi Zhang, Chi-Kong Lau, Jason Rawlings,…

  Source: Cell. 2009 Jul 23

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• Rapid-response splicing reporter screens identify differential regulators of constitutive and alternative splicing.

  Bioactive compounds have been invaluable for dissecting the mechanisms, regulation, and functions of cellular processes. However, very few such reagen…

  Authors: Ihab Younis, Michael Berg, Daisuke Kaida, Kimberly Dittmar, Congli Wang, Gideon Dreyfuss

  Source: Molecular and cellular biology. 2010 Apr

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• Why do cells need an assembly machine for RNA-protein complexes?

  Small nuclear ribonucleoproteins (snRNPs) are crucial for pre-mRNA processing to mRNAs. Each snRNP contains a small nuclear RNA (snRNA) and an extreme…

  Authors: Jeongsik Yong, Lili Wan, Gideon Dreyfuss

  Source: Trends in cell biology. 2004 May

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• The Gemin5 protein of the SMN complex identifies snRNAs.

  The survival of motor neurons protein (SMN) is part of a large complex that contains six other proteins, Gemins2-7. The SMN complex assembles the hept…

  Authors: Daniel J Battle, Chi-Kong Lau, Lili Wan, Hongying Deng, Francesco Lotti, Gideon Dreyfuss

  Source: Molecular cell. 2006 Jul 21

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• Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay.

  Nonsense-mediated mRNA decay (NMD) is a surveillance mechanism that degrades mRNA containing premature termination codons (PTCs). In mammalian cells, …

  Authors: Isao Kashima, Akio Yamashita, Natsuko Izumi, Naoyuki Kataoka, Ryo Morishita, Shinichi Hoshino, Mutsuhito Ohno, Gideon Dreyfuss, Shigeo Ohno

  Source: Genes & development. 2006 Feb 1

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