1 to 10 of 72 literature results

• Mechanisms of clofibrate-induced apoptosis in Yoshida AH-130 hepatoma cells.

  Peroxisome proliferators (PPs) are a class of compounds that exert their nominal effects through the peroxisome proliferator-activated receptors. PPs,…

  Authors: F Penna, P Reffo, G Muzio, R A Canuto, F M Baccino, G Bonelli, P Costelli

  Source: Biochemical pharmacology. 2009 Jan 15

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• Muscle myostatin signalling is enhanced in experimental cancer cachexia.

  BACKGROUND/AIMS: Myostatin belongs to the transforming growth factor-beta superfamily and negatively regulates skeletal muscle mass. Its deletion indu…

  Authors: P Costelli, M Muscaritoli, A Bonetto, F Penna, P Reffo, M Bossola, G Bonelli, G B Doglietto, F M Baccino, F Rossi Fanelli

  Source: European journal of clinical investigation. 2008 Jul

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• Mice lacking TNFalpha receptors 1 and 2 are resistant to death and fulminant liver injury induced by agonistic anti-Fas antibody.

  The liver is particularly susceptible to Fas-mediated cytotoxicity. Mice given an adequate parenteral dose of agonistic anti-Fas antibody (aFas) or of…

  Authors: P Costelli, P Aoki, B Zingaro, N Carbó, P Reffo, F J Lopez-Soriano, G Bonelli, J M Argilés, F M Baccino

  Source: Cell death and differentiation. 2003 Sep

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• Increased muscle proteasome activity correlates with disease severity in gastric cancer patients.

  OBJECTIVE: To investigate the state of activation of the ATP-ubiquitin-dependent proteolytic system in the skeletal muscle of gastric cancer patients.…

  Authors: Maurizio Bossola, Maurizio Muscaritoli, Paola Costelli, Gabriella Grieco, Gabriella Bonelli, Fabio Pacelli, Filippo Rossi Fanelli, Giovanni Battista Doglietto, Francesco Maria Baccino

  Source: Annals of surgery. 2003 Mar

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• Apoptosis induced by clofibrate in Yoshida AH-130 hepatoma cells: role of HMG-CoA reductase.

  Clofibrate is a hypolipidemic drug belonging to the peroxisome proliferator (PP) family. PPs are well-recognized hepatocarcinogens, though only for ro…

  Authors: Rosa A Canuto, Giuliana Muzio, Marina Maggiora, Antonella Trombetta, Germana Martinasso, Riccardo Autelli, Paola Costelli, Gabriella Bonelli, Francesco M Baccino

  Source: Journal of lipid research. 2003 Jan

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• Tolerance to the sedative effect of lorazepam correlates with a diminution in cortical release and affinity for glutamate.

  Benzodiazepines are anxiolytic, anticonvulsant, sedative and hypnotic compounds usually prescribed on a long-term basis. Chronic treatment with these …

  Authors: C D Bonavita, V Bisagno, C G Bonelli, G B Acosta, M C Rubio, S I Wikinski

  Source: Neuropharmacology. 2002 Apr

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• Skeletal muscle wasting in tumor-bearing rats is associated with MyoD down-regulation.

  Cachexia is a syndrome characterized by profound skeletal muscle wasting that frequently complicates malignancies. A number of studies indicate that p…

  Authors: P Costelli, M Muscaritoli, M Bossola, R Moore-Carrasco, S Crepaldi, G Grieco, R Autelli, G Bonelli, F Pacelli, F J Lopez-Soriano,…

  Source: International journal of oncology. 2005 Jun

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• Endosomal-lysosomal proteolysis mediates death signalling by TNFalpha, not by etoposide, in L929 fibrosarcoma cells: evidence for an active role of cathepsin D.

  In several 'in vitro' models of apoptosis, lysosomal proteolysis has been shown to play an active role in mediating the death signal by cytokines or a…

  Authors: Marina Démoz, Roberta Castino, Patrizia Cesaro, Francesco M Baccino, Gabriella Bonelli, Ciro Isidoro

  Source: Biological chemistry. 2002 Jul-Aug

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• Deacetylase inhibitors modulate the myostatin/follistatin axis without improving cachexia in tumor-bearing mice.

  Muscle wasting, as occurring in cancer cachexia, is primarily characterized by protein hypercatabolism and increased expression of ubiquitin ligases, …

  Authors: A Bonetto, F Penna, V G Minero, P Reffo, G Bonelli, F M Baccino, P Costelli

  Source: Current cancer drug targets. 2009 Aug

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• Increase in ceramide level alters the lysosomal targeting of cathepsin D prior to onset of apoptosis in HT-29 colon cancer cells.

  Ceramide has been suggested as an important mediator of apoptosis. In HT-29 colorectal cancer cells increased ceramide levels, induced by exogenous N-…

  Authors: Daniela De Stefanis, Patrizia Reffo, Gabriella Bonelli, Francesco M Baccino, Giuseppina Sala, Riccardo Ghidoni, Patrice Codogno, Ciro Isidoro

  Source: Biological chemistry. 2002 Jun

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