1 to 10 of 43 literature results

• Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis.

  Psoriasis is a common T cell-mediated autoimmune inflammatory disease. We show that blocking the interaction of alpha1beta1 integrin (VLA-1) with coll…

  Authors: Curdin Conrad, Onur Boyman, Giulia Tonel, Adrian Tun-Kyi, Ute Laggner, Antonin de Fougerolles, Victor Kotelianski, Humphrey Gardner, Frank O Nestle

  Source: Nature medicine. 2007 Jul

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• Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide.

  Plasmacytoid dendritic cells (pDCs) sense viral and microbial DNA through endosomal Toll-like receptors to produce type 1 interferons. pDCs do not nor…

  Authors: Roberto Lande, Josh Gregorio, Valeria Facchinetti, Bithi Chatterjee, Yi-Hong Wang, Bernhard Homey, Wei Cao, Yui-Hsi Wang, Bing Su, Frank O Nestle,…

  Source: Nature. 2007 Oct 4

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• The pathogenic role of tissue-resident immune cells in psoriasis.

  Psoriasis is a common chronic inflammatory skin disease, the study of which might also be of considerable value to the understanding of other inflamma…

  Authors: Onur Boyman, Curdin Conrad, Giulia Tonel, Michel Gilliet, Frank O Nestle

  Source: Trends in immunology. 2007 Feb

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• Metallurgy: high nickel release from 1- and 2-euro coins.

  The amount of nickel is regulated in European products that come into direct and prolonged contact with human skin because this metal may cause contac…

  Authors: Frank O Nestle, Hannes Speidel, Markus O Speidel

  Source: Nature. 2002 Sep 12

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• Dendritic-cell-based therapeutic vaccination against cancer.

  Early clinical trials, in which over 1000 cancer patients received dendritic cell (DC) vaccines, tested different vaccine preparations, but they did n…

  Authors: Frank O Nestle, Arpad Farkas, Curdin Conrad

  Source: Current opinion in immunology. 2005 Apr

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• A new lease on life for dendritic cell vaccines?

  Authors: Frank O Nestle

  Source: Nature biotechnology. 2006 Dec

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• Infliximab induction and maintenance therapy for moderate-to-severe psoriasis: a phase III, multicentre, double-blind trial.

  BACKGROUND: Tumour necrosis factor alpha (TNFalpha) is thought to play a part in the pathogenesis of psoriasis. We assessed the efficacy and safety of…

  Authors: Kristian Reich, Frank O Nestle, Kim Papp, Jean-Paul Ortonne, Robert Evans, Cynthia Guzzo, Shu Li, Lisa T Dooley, Christopher E M Griffiths, EXPRESS study investigators

  Source: Lancet. 2005 Oct 15-21

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• Identification of ZNF313/RNF114 as a novel psoriasis susceptibility gene.

  Psoriasis is an immune-mediated skin disorder that is inherited as a multifactorial trait. Linkage studies have clearly identified a primary disease s…

  Authors: Francesca Capon, Marie-José Bijlmakers, Natalie Wolf, Maria Quaranta, Ulrike Huffmeier, Michael Allen, Kirsten Timms, Victor Abkevich, Alexander Gutin, Rhodri Smith,…

  Source: Human molecular genetics. 2008 Jul 1

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• Intranodal injection of semimature monocyte-derived dendritic cells induces T helper type 1 responses to protein neoantigen.

  Dendritic cells (DCs) represent the most potent antigen-presenting cells of the immune system capable of initiating primary immune responses to neoant…

  Authors: Michel Gilliet, Martin Kleinhans, Erica Lantelme, Dirk Schadendorf, Günter Burg, Frank O Nestle

  Source: Blood. 2003 Jul 1

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• Functional expression of the eotaxin receptor CCR3 in CD30+ cutaneous T-cell lymphoma.

  Little is known about mechanisms involved in skin-specific homing of cutaneous T-cell lymphoma (CTCL). Chemokine/chemokine receptor interactions have …

  Authors: Martin Kleinhans, Adrian Tun-Kyi, Michel Gilliet, Marshall E Kadin, Reinhard Dummer, Günter Burg, Frank O Nestle

  Source: Blood. 2003 Feb 15

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