1 to 10 of 122 literature results

• The case for a US prospective cohort study of genes and environment.

  Information from the Human Genome Project will be vital for defining the genetic and environmental factors that contribute to health and disease. Well…

  Authors: Francis S Collins

  Source: Nature. 2004 May 27

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• A mouse for all reasons.

  Three major mouse knockout programs are underway worldwide, working together to mutate all protein-encoding genes in the mouse using a combination of …

  Authors: International Mouse Knockout Consortium, Francis S Collins, Janet Rossant, Wolfgang Wurst

  Source: Cell. 2007 Jan 12

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• What we do and don't know about 'race', 'ethnicity', genetics and health at the dawn of the genome era.

  A true understanding of disease risk requires a thorough examination of root causes. 'Race' and 'ethnicity' are poorly defined terms that serve as fla…

  Authors: Francis S Collins

  Source: Nature genetics. 2004 Nov

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• The HapMap and genome-wide association studies in diagnosis and therapy.

  The International HapMap Project produced a genome-wide database of human genetic variation for use in genetic association studies of common diseases.…

  Authors: Teri A Manolio, Francis S Collins

  Source: Annual review of medicine. 2009

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• Finding the missing heritability of complex diseases.

  Genome-wide association studies have identified hundreds of genetic variants associated with complex human diseases and traits, and have provided valu…

  Authors: Teri A Manolio, Francis S Collins, Nancy J Cox, David B Goldstein, Lucia A Hindorff, David J Hunter, Mark I McCarthy, Erin M Ramos, Lon R Cardon, Aravinda Chakravarti,…

  Source: Nature. 2009 Oct 8

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• Common variants at 30 loci contribute to polygenic dyslipidemia.

  Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglyceride levels are risk factors for cardiovascula…

  Authors: Sekar Kathiresan, Cristen J Willer, Gina M Peloso, Serkalem Demissie, Kiran Musunuru, Eric E Schadt, Lee Kaplan, Derrick Bennett, Yun Li, Toshiko Tanaka,…

  Source: Nature genetics. 2009 Jan

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• Merging and emerging cohorts: necessary but not sufficient.

  Authors: Francis S Collins, Teri A Manolio

  Source: Nature. 2007 Jan 18

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• Newly identified loci that influence lipid concentrations and risk of coronary artery disease.

  To identify genetic variants influencing plasma lipid concentrations, we first used genotype imputation and meta-analysis to combine three genome-wide…

  Authors: Cristen J Willer, Serena Sanna, Anne U Jackson, Angelo Scuteri, Lori L Bonnycastle, Robert Clarke, Simon C Heath, Nicholas J Timpson, Samer S Najjar, Heather M Stringham,…

  Source: Nature genetics. 2008 Feb

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• Mechanisms of cardiovascular disease in accelerated aging syndromes.

  In the past several years, remarkable progress has been made in the understanding of the mechanisms of premature aging. These rare, genetic conditions…

  Authors: Brian C Capell, Francis S Collins, Elizabeth G Nabel

  Source: Circulation research. 2007 Jul 6

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• Common variants in the GDF5-UQCC region are associated with variation in human height.

  Identifying genetic variants that influence human height will advance our understanding of skeletal growth and development. Several rare genetic varia…

  Authors: Serena Sanna, Anne U Jackson, Ramaiah Nagaraja, Cristen J Willer, Wei-Min Chen, Lori L Bonnycastle, Haiqing Shen, Nicholas Timpson, Guillaume Lettre, Gianluca Usala,…

  Source: Nature genetics. 2008 Feb

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