1 to 10 of 19 literature results

• Patterns of somatic mutation in human cancer genomes.

  Cancers arise owing to mutations in a subset of genes that confer growth advantage. The availability of the human genome sequence led us to propose th…

  Authors: Christopher Greenman, Philip Stephens, Raffaella Smith, Gillian L Dalgliesh, Christopher Hunter, Graham Bignell, Helen Davies, Jon Teague, Adam Butler, Claire Stevens,…

  Source: Nature. 2007 Mar 8

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• A screen of the complete protein kinase gene family identifies diverse patterns of somatic mutations in human breast cancer.

  We examined the coding sequence of 518 protein kinases, approximately 1.3 Mb of DNA per sample, in 25 breast cancers. In many tumors, we detected no s…

  Authors: Philip Stephens, Sarah Edkins, Helen Davies, Chris Greenman, Charles Cox, Chris Hunter, Graham Bignell, Jon Teague, Raffaella Smith, Claire Stevens,…

  Source: Nature genetics. 2005 Jun

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• Lung cancer: intragenic ERBB2 kinase mutations in tumours.

  The protein-kinase family is the most frequently mutated gene family found in human cancer and faulty kinase enzymes are being investigated as promisi…

  Authors: Philip Stephens, Chris Hunter, Graham Bignell, Sarah Edkins, Helen Davies, Jon Teague, Claire Stevens, Sarah O'Meara, Raffaella Smith, Adrian Parker,…

  Source: Nature. 2004 Sep 30

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• Tumor-specific shared antigenic peptides recognized by human T cells.

  The first tumor-specific shared antigens and the cancer-germline genes that code for these antigens were identified with antitumor cytolytic T lymphoc…

  Authors: Pierre Van Der Bruggen, Yi Zhang, Pascal Chaux, Vincent Stroobant, Christophe Panichelli, Erwin S Schultz, Jacques Chapiro, Benoît J Van Den Eynde, Francis Brasseur, Thierry Boon

  Source: Immunological reviews. 2002 Oct

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• DNA microarray to monitor the expression of MAGE-A genes.

  BACKGROUND: The MAGE-A genes encode antigens that are of particular interest for antitumor immunotherapy because they are strictly tumor specific and …

  Authors: Nathalie Zammatteo, Laurence Lockman, Francis Brasseur, Etienne De Plaen, Christophe Lurquin, Pierre-Emmanuel Lobert, Sandrine Hamels, Thierry Boon, José Remacle

  Source: Clinical chemistry. 2002 Jan

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• Selective cancer-germline gene expression in pediatric brain tumors.

  Cancer-germline genes (CGGs) code for immunogenic antigens that are present in various human tumors and can be targeted by immunotherapy. Their expres…

  Authors: Joannes F M Jacobs, Oliver M Grauer, Francis Brasseur, Peter M Hoogerbrugge, Pieter Wesseling, Corrie E Gidding, Mandy W M M van de Rakt, Carl G Figdor, Pierre G Coulie, I Jolanda M de Vries,…

  Source: Journal of neuro-oncology. 2008 Jul

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• Somatic mutations of the protein kinase gene family in human lung cancer.

  Protein kinases are frequently mutated in human cancer and inhibitors of mutant protein kinases have proven to be effective anticancer drugs. We scree…

  Authors: Helen Davies, Chris Hunter, Raffaella Smith, Philip Stephens, Chris Greenman, Graham Bignell, Jon Teague, Adam Butler, Sarah Edkins, Claire Stevens,…

  Source: Cancer research. 2005 Sep 1

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• Expression of BORIS in melanoma: lack of association with MAGE-A1 activation.

  Several genes with specific expression in germ cells show aberrant activation in different types of tumors. These genes, termed cancer-germline (CG) g…

  Authors: Olga Kholmanskikh, Axelle Loriot, Francis Brasseur, Etienne De Plaen, Charles De Smet

  Source: International journal of cancer. Journal international du cancer. 2008 Feb 15

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• Unambiguous identification of the expressed MAGE-A genes on a DNA microarray.

  Authors: Nathalie Zammatteo, Caroline Davril, Francis Brasseur, Sandrine Hamels, Etienne De Plaen, Thierry Boon, José Remacle

  Source: Clinical chemistry. 2005 Dec

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• Human periostin gene expression in normal tissues, tumors and melanoma: evidences for periostin production by both stromal and melanoma cells.

  BACKGROUND: Recently, periostin (POSTN), a gene encoding a protein with similarity to the fasciclin family and involved in cell survival and angiogene…

  Authors: Gaëlle Tilman, Marina Mattiussi, Francis Brasseur, Nicolas van Baren, Anabelle Decottignies

  Source: Molecular cancer. 2007

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